HitPredict

Interactor 1: K2C5 (P13647)
Keratin, type II cytoskeletal 5 (58 kDa cytokeratin) (Cytokeratin-5) (CK-5) (Keratin-5) (K5) (Type-II keratin Kb5)
Gene: KRT5

Interactor 2: K2C1B (Q7Z794)
Keratin, type II cytoskeletal 1b (Cytokeratin-1B) (CK-1B) (Keratin-77) (K77) (Type-II keratin Kb39)
Gene: KRT77

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	35575683
Identification Methods	cross-linking study
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Filament~Filament
Common GO terms	GO:0005829 - cytosol GO:0030280 - structural constituent of skin epidermis GO:0031424 - keratinization GO:0045095 - keratin filament GO:0045109 - intermediate filament organization and 1 others more... GO:0070062 - extracellular exosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 590 Hs			1 578
+	Hs
		407358 K2C8_HUMAN (140-516): 9.22e-163: 474: 69.23		K2C1_HUMAN (129-510): 2.72e-162: 479: 68.06
+	Hs
		437069 K2C3_HUMAN (140-484): 3.96e-178: 519: 78.10		K2C8_HUMAN (136-521): 2.31e-135: 404: 55.70
+	Hs
		437110 K22E_HUMAN (140-484): 3.02e-174: 509: 71.88		K2C8_HUMAN (136-521): 2.31e-135: 404: 55.70
+	Hs
		475746 K22E_HUMAN (140-484): 3.02e-174: 509: 71.88		K2C7_HUMAN (94-491): 1.86e-132: 396: 56.75
+	Hs
		437054 K2C8_HUMAN (140-516): 9.22e-163: 474: 69.23		K2C8_HUMAN (136-521): 2.31e-135: 404: 55.70
+	Hs
		437063 K2C8_HUMAN (140-516): 9.22e-163: 474: 69.23		K2C7_HUMAN (94-491): 1.86e-132: 396: 56.75
+	Hs
		551596 K2C3_HUMAN (140-484): 3.96e-178: 519: 78.10		KRT84_HUMAN (5-560): 1.41e-101: 321: 42.93
+	Hs
		777568 K22E_HUMAN (140-484): 3.02e-174: 509: 71.88		KRT84_HUMAN (5-560): 1.41e-101: 321: 42.93
+	Hs
		341729 K2C3_HUMAN (140-484): 3.96e-178: 519: 78.10		K2C75_HUMAN (1-566): 5.19e-96: 305: 53.95
+	Hs
		341741 K22E_HUMAN (140-484): 3.02e-174: 509: 71.88		K2C75_HUMAN (1-566): 5.19e-96: 305: 53.95
+	Hs
		551532 K2C3_HUMAN (140-484): 3.96e-178: 519: 78.10		K2C5_HUMAN (1-480): 3.6e-83: 272: 59.26
+	Hs
		566337 K22E_HUMAN (140-484): 3.02e-174: 509: 71.88		K2C5_HUMAN (1-480): 3.6e-83: 272: 59.26
+	Hs
		341724 K2C8_HUMAN (140-516): 9.22e-163: 474: 69.23		K2C75_HUMAN (1-566): 5.19e-96: 305: 53.95
+	Hs
		385226 K2C3_HUMAN (140-484): 3.96e-178: 519: 78.10		K2C6A_HUMAN (4-501): 1.36e-77: 257: 58.12
+	Hs
		385242 K22E_HUMAN (140-484): 3.02e-174: 509: 71.88		K2C6A_HUMAN (4-501): 1.36e-77: 257: 58.12
+	Hs
		227198 K2C8_HUMAN (140-516): 9.22e-163: 474: 69.23		KRT86_HUMAN (46-485): 1.37e-88: 284: 43.31
+	Hs
		407237 K2C8_HUMAN (140-516): 9.22e-163: 474: 69.23		K2C6B_HUMAN (4-501): 2.56e-81: 267: 58.12
+	Hs
		551555 K2C3_HUMAN (140-484): 3.96e-178: 519: 78.10		K1H2_HUMAN (68-477): 3.2e-65: 221: 21.46
+	Hs
		385216 K2C8_HUMAN (140-516): 9.22e-163: 474: 69.23		K2C6A_HUMAN (4-501): 1.36e-77: 257: 58.12
+	Hs
		777464 K22E_HUMAN (140-484): 3.02e-174: 509: 71.88		K1H2_HUMAN (68-477): 3.2e-65: 221: 21.46