HitPredict

Interactor 1: K2C1 (P04264)
Keratin, type II cytoskeletal 1 (67 kDa cytokeratin) (Cytokeratin-1) (CK-1) (Hair alpha protein) (Keratin-1) (K1) (Type-II keratin Kb1)
Gene: KRT1

Interactor 2: K2C8 (P05787)
Keratin, type II cytoskeletal 8 (Cytokeratin-8) (CK-8) (Keratin-8) (K8) (Type-II keratin Kb8)
Gene: KRT8

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.56	1.00	0.754

Property	Details
Experiments	34079125, 35575683
Identification Methods	proximity labelling technology, cross-linking study
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Filament~Filament
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0045095 - keratin filament GO:0070062 - extracellular exosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 644 Hs			1 483
+	Hs
		437146 K2C8_HUMAN (152-543): 4.06e-144: 429: 59.44		K22O_HUMAN (63-416): 2.26e-152: 449: 65.73
+	Hs
		437063 K2C8_HUMAN (152-543): 4.06e-144: 429: 59.44		K2C7_HUMAN (1-464): 4.57e-154: 448: 60.34
+	Hs
		437069 K2C8_HUMAN (152-543): 4.06e-144: 429: 59.44		K2C3_HUMAN (63-424): 5.18e-135: 405: 65.95
+	Hs
		437255 K2C8_HUMAN (152-543): 4.06e-144: 429: 59.44		K2C73_HUMAN (1-405): 2.06e-86: 277: 55.85
+	Hs
		227198 K2C8_HUMAN (152-543): 4.06e-144: 429: 59.44		KRT86_HUMAN (12-417): 2.63e-86: 275: 53.20
+	Hs
		341724 K2C8_HUMAN (152-543): 4.06e-144: 429: 59.44		K2C75_HUMAN (2-405): 7.56e-80: 260: 64.04
+	Hs
		437215 K2C8_HUMAN (152-543): 4.06e-144: 429: 59.44		K2C79_HUMAN (8-418): 7.92e-78: 254: 56.97
+	Hs
		437198 K2C8_HUMAN (152-543): 4.06e-144: 429: 59.44		K2C71_HUMAN (1-405): 4.92e-75: 247: 54.85
+	Hs
		341727 K2C7_HUMAN (138-505): 3.97e-137: 410: 60.33		K2C75_HUMAN (2-405): 7.56e-80: 260: 64.04
+	Hs
		437176 K2C8_HUMAN (152-543): 4.06e-144: 429: 59.44		K2C72_HUMAN (11-405): 3.99e-72: 238: 58.48
+	Hs
		407237 K2C8_HUMAN (152-543): 4.06e-144: 429: 59.44		K2C6B_HUMAN (56-405): 2.5e-67: 227: 70.46
+	Hs
		437077 K2C8_HUMAN (152-543): 4.06e-144: 429: 59.44		K2C5_HUMAN (56-405): 3.4e-67: 227: 71.02
+	Hs
		437121 K2C8_HUMAN (152-543): 4.06e-144: 429: 59.44		K2C6C_HUMAN (56-405): 2.5e-67: 227: 70.74
+	Hs
		385216 K2C8_HUMAN (152-543): 4.06e-144: 429: 59.44		K2C6A_HUMAN (56-405): 8.77e-66: 223: 70.74
+	Hs
		437236 K2C8_HUMAN (152-543): 4.06e-144: 429: 59.44		K2C74_HUMAN (2-454): 2.87e-66: 223: 48.58
+	Hs
		437054 K2C8_HUMAN (152-543): 4.06e-144: 429: 59.44		K2C8_HUMAN (1-483): 1.21e-64: 218: 100.00
+	Hs
		300545 K2C8_HUMAN (152-543): 4.06e-144: 429: 59.44		KRT36_HUMAN (5-449): 5.8e-64: 216: 23.54
+	Hs
		437292 K2C8_HUMAN (152-543): 4.06e-144: 429: 59.44		KRT35_HUMAN (1-402): 2.84e-64: 216: 25.43
+	Hs
		437172 K2C8_HUMAN (152-543): 4.06e-144: 429: 59.44		K1H2_HUMAN (88-408): 6.87e-64: 215: 26.71
+	Hs
		437365 K2C8_HUMAN (152-543): 4.06e-144: 429: 59.44		KRT84_HUMAN (176-469): 1.9e-12: 71.4: 13.21