HitPredict

Interactor 1: IRF2 (P14316)
Interferon regulatory factor 2 (IRF-2)
Gene: IRF2

Interactor 2: TRI25 (Q14258)
E3 ubiquitin/ISG15 ligase TRIM25 (EC 6.3.2.n3) (Estrogen-responsive finger protein) (RING finger protein 147) (RING-type E3 ubiquitin transferase) (EC 2.3.2.27) (RING-type E3 ubiquitin transferase TRIM25) (Tripartite motif-containing protein 25) (Ubiquitin/ISG15-conjugating enzyme TRIM25) (Zinc finger protein 147)
Gene: TRIM25

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	30833792
Identification Methods	affinity chromatography technology, pull down
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005654 - nucleoplasm GO:0005829 - cytosol
Homologous interactions	11

Homologous interactions

Color coding for hit scores

	1 349 Hs			1 630
+	Hs
		137373 IRF1_HUMAN (1-265): 1.74e-104: 311: 46.69		BT3A3_HUMAN (349-630): 2.67e-79: 264: 19.19
+	Hs
		186539 IRF8_HUMAN (7-215): 1.4e-59: 199: 31.91		TRI18_HUMAN (4-629): 3.86e-113: 355: 22.47
+	Mm
		267244 IRF3_MOUSE (1-147): 3.99e-58: 195: 31.08		TRI18_MOUSE (4-629): 6.04e-108: 342: 21.13
+	Hs
		186547 IRF3_HUMAN (1-211): 4.18e-52: 180: 24.54		TRI18_HUMAN (4-629): 3.86e-113: 355: 22.47
+	Hs
		623290 IRF8_HUMAN (7-215): 1.4e-59: 199: 31.91		RO52_HUMAN (2-263): 6.24e-30: 125: 18.32
+	Hs
		623330 IRF5_HUMAN (2-119): 8.89e-54: 185: 42.37		RO52_HUMAN (2-263): 6.24e-30: 125: 18.32
+	Hs
		623346 IRF3_HUMAN (1-211): 4.18e-52: 180: 24.54		RO52_HUMAN (2-263): 6.24e-30: 125: 18.32
+	Hs
		142679 IRF8_HUMAN (7-215): 1.4e-59: 199: 31.91		TRI38_HUMAN (5-299): 9.54e-23: 103: 15.13
+	Hs
		1129189 IRF3_HUMAN (1-211): 4.18e-52: 180: 24.54		TRIM7_HUMAN (10-413): 7.16e-25: 110: 15.00
+	Hs
		623470 IRF7_HUMAN (4-111): 1.04e-38: 145: 32.48		RO52_HUMAN (2-263): 6.24e-30: 125: 18.32
+	Hs
		1110894 IRF5_HUMAN (2-119): 8.89e-54: 185: 42.37		TRI35_HUMAN (9-80): 1.96e-10: 65.5: 45.21