Protein: IRF3
Interferon regulatory factor 3 (IRF-3)

Gene: IRF3
Organism: Mus musculus
Interactions: 26
UniProt ID: P70671

Gene Ontology (top 5):
GO:0000785 - chromatin
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001228 - DNA-binding transcription activator activity, RNA polymerase II-specific
GO:0002753 - cytoplasmic pattern recognition receptor signaling pathway

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1000525

IRF3
Interferon regulatory factor 3

5

15

Small-scale

0.906

High

378387

IFNB
Interferon beta

6

20

Small-scale

0.721

High

74267

EP300
Histone acetyltransferase p300

1

17

Small-scale

0.618

High

1000250

TANK
TRAF family member-associated NF-kappa-B activator

2

2

Small-scale

0.584

High

1000537

TBK1
Serine/threonine-protein kinase TBK1

1

14

Small-scale

0.561

High

1000535

ZBP1
Z-DNA-binding protein 1

2

0

Small-scale

0.559

High

548941

KCC2A
Calcium/calmodulin-dependent protein kinase type II subunit alpha

1

0

Small-scale

0.530

High

1000531

RNF41
E3 ubiquitin-protein ligase NRDP1

1

20

Small-scale

0.515

High

267244

TRI18
E3 ubiquitin-protein ligase Midline-1

1

15

Small-scale

0.479

High

456564

IFNA4
Interferon alpha-4

1

20

Small-scale

0.479

High

462112

HS90A
Heat shock protein HSP 90-alpha

1

7

Small-scale

0.479

High

547247

HS90B
Heat shock protein HSP 90-beta

1

7

Small-scale

0.479

High

576912

HMOX1
Heme oxygenase 1

1

1

Small-scale

0.479

High

991475

SUMO1
Small ubiquitin-related modifier 1

1

6

Small-scale

0.479

High

1000076

PITX1
Pituitary homeobox 1

1

1

Small-scale

0.479

High

1000527

NCOA2
Nuclear receptor coactivator 2

1

2

Small-scale

0.479

High

1000528

ISG15
Ubiquitin-like protein ISG15

1

10

Small-scale

0.479

High

1000529

RIGI
Antiviral innate immune response receptor RIG-I

1

7

High-throughput

0.479

High

1000530

TCAM1
TIR domain-containing adapter molecule 1

1

5

Small-scale

0.479

High

1000533

TRI26
Tripartite motif-containing protein 26

1

11

Small-scale

0.479

High

1000534

IL23A
Interleukin-23 subunit alpha

1

2

Small-scale

0.479

High

1000536

UBP18
Ubl carboxyl-terminal hydrolase 18

1

3

Small-scale

0.479

High

1000526

I12R1
Interleukin-12 receptor subunit beta-1

1

3

Small-scale

0.437

High

1000532

GRIP1
Glutamate receptor-interacting protein 1

1

2

Small-scale

0.437

High

1000538

SUMO3
Small ubiquitin-related modifier 3

1

6

Small-scale

0.437

High


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Last updated: 11Aug2025