Protein: IRF5
Interferon regulatory factor 5 (IRF-5)

Gene: IRF5
Organism: Homo sapiens
Interactions: 73
UniProt ID: Q13568

Gene Ontology (top 5):
GO:0000785 - chromatin
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001228 - DNA-binding transcription activator activity, RNA polymerase II-specific
GO:0002376 - immune system process

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1110865

IRF5
Interferon regulatory factor 5

6

15

Small-scale

0.943

High

1110875

CBP
CREB-binding protein

2

17

Small-scale

0.834

High

1110867

IRF3
Interferon regulatory factor 3

2

16

Small-scale

0.768

High

1110878

IRF7
Interferon regulatory factor 7

2

15

Small-scale

0.754

High

1067290

EP300
Histone acetyltransferase p300

1

17

Small-scale

0.724

High

167189

IRF6
Interferon regulatory factor 6

1

15

High-throughput

0.691

High

324127

CE152
Centrosomal protein of 152 kDa

3

4

High-throughput

0.656

High

1110884

MYD88
Myeloid differentiation primary response protein MyD88

2

20

Small-scale

0.624

High

533931

IRF1
Interferon regulatory factor 1

1

15

Small-scale

0.618

High

838087

STAT1
Signal transducer and activator of transcription 1-alpha/beta

1

20

Small-scale

0.618

High

913133

STAT2
Signal transducer and activator of transcription 2

1

20

Small-scale

0.618

High

1028127

IRF9
Interferon regulatory factor 9

1

17

Small-scale

0.618

High

1094328

CSN1
COP9 signalosome complex subunit 1

2

3

Small-scale

0.611

High

1045261

TF65
Transcription factor p65

2

20

Small-scale

0.601

High

1110873

MAVS
Mitochondrial antiviral-signaling protein

1

3

High-throughput

0.586

High

712729

IL12A
Interleukin-12 subunit alpha

2

7

Small-scale

0.584

High

1110895

TRAF6
TNF receptor-associated factor 6

2

20

Small-scale

0.584

High

226768

SGTA
Small glutamine-rich tetratricopeptide repeat-containing protein alpha

1

6

High-throughput

0.573

High

623330

RO52
E3 ubiquitin-protein ligase TRIM21

1

9

Small-scale

0.561

High

1109698

HDAC1
Histone deacetylase 1

1

5

Small-scale

0.561

High

1110892

CSN3
COP9 signalosome complex subunit 3

1

5

Small-scale

0.561

High

1110896

NCOR2
Nuclear receptor corepressor 2

1

3

Small-scale

0.561

High

1110874

S15A4
Solute carrier family 15 member 4

1

1

Small-scale

0.554

High

1110887

TRI15
E3 ubiquitin-protein ligase TRIM15

1

11

High-throughput

0.541

High

1110880

SIN3A
Paired amphipathic helix protein Sin3a

1

0

Small-scale

0.537

High

124915

GTPB1
GTP-binding protein 1

1

2

High-throughput

0.536

High

586291

ZEP1
Zinc finger protein 40

1

1

High-throughput

0.536

High

890648

RGS3
Regulator of G-protein signaling 3

1

2

High-throughput

0.536

High

378235

IFNA1
Interferon alpha-1/13

1

20

Small-scale

0.515

High

378331

IFN14
Interferon alpha-14

1

20

Small-scale

0.515

High

656114

PPIB
Peptidyl-prolyl cis-trans isomerase B

1

1

High-throughput

0.515

High

1099859

TIF1B
Transcription intermediary factor 1-beta

1

13

Small-scale

0.515

High

1110869

SETB1
Histone-lysine N-methyltransferase SETDB1

1

3

Small-scale

0.515

High

187077

PPM1G
Protein phosphatase 1G

1

0

High-throughput

0.513

High

987617

GRB2
Growth factor receptor-bound protein 2

1

0

High-throughput

0.513

High

157336

CTRO
Citron Rho-interacting kinase

1

1

High-throughput

0.500

High

1110881

PSB7
Proteasome subunit beta type-7

1

9

High-throughput

0.500

High

1110886

GTPB2
GTP-binding protein 2

1

2

High-throughput

0.489

High

163298

TR10B
Tumor necrosis factor receptor superfamily member 10B

1

1

Small-scale

0.479

High

172789

XPO1
Exportin-1

1

3

Small-scale

0.479

High

177213

ANR28
Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A

1

3

High-throughput

0.479

High

177867

IKKA
Inhibitor of nuclear factor kappa-B kinase subunit alpha

1

15

Small-scale

0.479

High

185674

OGT1
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit

1

2

Small-scale

0.479

High

253624

IMA7
Importin subunit alpha-7

1

5

Small-scale

0.479

High

278337

NCOR1
Nuclear receptor corepressor 1

1

7

Small-scale

0.479

High

378376

IFNB
Interferon beta

1

20

Small-scale

0.479

High

413785

P53
Cellular tumor antigen p53

1

4

Small-scale

0.479

High

647314

IL10
Interleukin-10

1

1

Small-scale

0.479

High

712747

IL12B
Interleukin-12 subunit beta

1

8

Small-scale

0.479

High

897141

TNF10
Tumor necrosis factor ligand superfamily member 10

1

7

Small-scale

0.479

High

911235

IMA5
Importin subunit alpha-5

1

5

Small-scale

0.479

High

958632

CSN2
COP9 signalosome complex subunit 2

1

5

Small-scale

0.479

High

1106831

BIRC3
Baculoviral IAP repeat-containing protein 3

1

3

Small-scale

0.479

High

1110868

CASP8
Caspase-8

1

3

Small-scale

0.479

High

1110870

PP6R3
Serine/threonine-protein phosphatase 6 regulatory subunit 3

1

1

High-throughput

0.479

High

1110872

CSN6
COP9 signalosome complex subunit 6

1

1

Small-scale

0.479

High

1110876

KAT2B
Histone acetyltransferase KAT2B

1

8

Small-scale

0.479

High

1110877

CSN5
COP9 signalosome complex subunit 5

1

2

Small-scale

0.479

High

1110879

PELI1
E3 ubiquitin-protein ligase pellino homolog 1

1

1

Small-scale

0.479

High

1110883

CCL19
C-C motif chemokine 19

1

10

Small-scale

0.479

High

1110885

CSN4
COP9 signalosome complex subunit 4

1

1

Small-scale

0.479

High

1110888

IL23A
Interleukin-23 subunit alpha

1

2

Small-scale

0.479

High

1110891

PACN2
Protein kinase C and casein kinase substrate in neurons protein 2

1

1

High-throughput

0.479

High

1110893

PP6R1
Serine/threonine-protein phosphatase 6 regulatory subunit 1

1

4

High-throughput

0.479

High

1110894

TRI35
E3 ubiquitin-protein ligase TRIM35

1

11

Small-scale

0.479

High

249975

OGA
Protein O-GlcNAcase

1

0

Small-scale

0.458

High

1110871

WAC2A
WASH complex subunit 2A

1

0

High-throughput

0.458

High

1110882

CSN8
COP9 signalosome complex subunit 8

1

0

Small-scale

0.458

High

1110889

CSN7A
COP9 signalosome complex subunit 7a

1

0

Small-scale

0.458

High

1110866

FLOT2
Flotillin-2

1

6

High-throughput

0.457

High

1110890

TBK1
Serine/threonine-protein kinase TBK1

1

14

Small-scale

0.445

High

488310

PPBI
Intestinal-type alkaline phosphatase

1

0

Small-scale

0.292

High


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Last updated: 11Aug2025