HitPredict

Interactor 1: INSRR (P14616)
Insulin receptor-related protein (IRR) (EC 2.7.10.1) (IR-related receptor) [Cleaved into: Insulin receptor-related protein alpha chain; Insulin receptor-related protein beta chain]
Gene: INSRR

Interactor 2: OSBL8 (Q9BZF1)
Oxysterol-binding protein-related protein 8 (ORP-8) (OSBP-related protein 8)
Gene: OSBPL8

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.80	0.618

Property	Details
Experiments	33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	PH~PK_Tyr_Ser-Thr
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1297 Hs			1 889
+	Hs
		465638 IGF1R_HUMAN (9-1265): 0: 1177: 55.66		OSBL8_HUMAN (1-889): 0: 1213: 100.00
+	Hs
		572957 INSRR_HUMAN (1-1297): 0: 1362: 100.00		OSBL5_HUMAN (32-889): 0: 1015: 54.21
+	Hs
		710468 EPHA2_HUMAN (455-1289): 0: 561: 21.88		OSBL8_HUMAN (1-889): 0: 1213: 100.00
+	Hs
		710753 EPHA8_HUMAN (649-1268): 5.38e-173: 541: 24.11		OSBL8_HUMAN (1-889): 0: 1213: 100.00
+	Hs
		465622 IGF1R_HUMAN (9-1265): 0: 1177: 55.66		OSBL9_HUMAN (209-743): 4.58e-161: 490: 30.32
+	Hs
		465636 IGF1R_HUMAN (9-1265): 0: 1177: 55.66		OSB11_HUMAN (345-749): 8.43e-131: 411: 29.62
+	Hs
		1419819 ALK_HUMAN (946-1247): 1.07e-70: 263: 43.46		OSBL8_HUMAN (1-889): 0: 1213: 100.00
+	Hs
		412567 NTRK1_HUMAN (957-1247): 1.28e-65: 240: 42.91		OSBL8_HUMAN (1-889): 0: 1213: 100.00
+	Hs
		1157058 NTRK3_HUMAN (957-1242): 2.06e-62: 231: 40.84		OSBL8_HUMAN (1-889): 0: 1213: 100.00
+	Hs
		541672 FGFR1_HUMAN (948-1294): 6.84e-59: 221: 35.90		OSBL8_HUMAN (1-889): 0: 1213: 100.00
+	Hs
		439843 INSR_HUMAN (5-179): 6.45e-12: 72.8: 20.67		OSBL8_HUMAN (1-889): 0: 1213: 100.00
+	Hs
		477262 ROS1_HUMAN (764-900): 1.06e-10: 68.9: 22.63		OSBL8_HUMAN (1-889): 0: 1213: 100.00
+	Hs
		710459 EPHA2_HUMAN (455-1289): 0: 561: 21.88		OSB10_HUMAN (283-749): 1.42e-140: 437: 29.46
+	Hs
		710755 EPHA8_HUMAN (649-1268): 5.38e-173: 541: 24.11		OSBL2_HUMAN (323-758): 8.31e-138: 420: 23.19
+	Hs
		412477 NTRK1_HUMAN (957-1247): 1.28e-65: 240: 42.91		OSBL9_HUMAN (209-743): 4.58e-161: 490: 30.32
+	Hs
		541649 FGFR1_HUMAN (948-1294): 6.84e-59: 221: 35.90		OSBL9_HUMAN (209-743): 4.58e-161: 490: 30.32
+	Hs
		411349 NTRK1_HUMAN (957-1247): 1.28e-65: 240: 42.91		OSBP1_HUMAN (236-758): 6.16e-142: 442: 20.25
+	Hs
		643362 NTRK3_HUMAN (957-1242): 2.06e-62: 231: 40.84		OSBP1_HUMAN (236-758): 6.16e-142: 442: 20.25
+	Hs
		412555 NTRK1_HUMAN (957-1247): 1.28e-65: 240: 42.91		OSB11_HUMAN (345-749): 8.43e-131: 411: 29.62
+	Hs
		541667 FGFR1_HUMAN (948-1294): 6.84e-59: 221: 35.90		OSB11_HUMAN (345-749): 8.43e-131: 411: 29.62