HitPredict

Interactor 1: ITB5 (P18084)
Integrin beta-5
Gene: ITGB5

Interactor 2: FAK1 (Q05397)
Focal adhesion kinase 1 (FADK 1) (EC 2.7.10.2) (Focal adhesion kinase-related nonkinase) (FRNK) (Protein phosphatase 1 regulatory subunit 71) (PPP1R71) (Protein-tyrosine kinase 2) (p125FAK) (pp125FAK)
Gene: PTK2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.64	0.60	0.624

Property	Details
Experiments	11927607, 15673687
Identification Methods	pull down, affinity chromatography technology
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005178 - integrin binding GO:0005886 - plasma membrane GO:0005925 - focal adhesion GO:0007179 - transforming growth factor beta receptor signaling pathway GO:0007229 - integrin-mediated signaling pathway and 1 others more... GO:0016477 - cell migration
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 799 Hs			1 1052
+	Hs
		396582 ITB3_HUMAN (4-788): 0: 716: 53.87		FAK1_HUMAN (1-1052): 0: 1127: 100.00
+	Hs
		403864 ITB1_HUMAN (8-789): 0: 716: 41.68		FAK1_HUMAN (1-1052): 0: 1127: 100.00
+	Rn
		192644 ITB1_RAT (8-789): 0: 723: 41.68		FAK1_RAT (1-1052): 0: 1111: 96.59
+	Hs
		556436 ITB4_HUMAN (4-717): 0: 607: 32.65		FAK1_HUMAN (1-1052): 0: 1127: 100.00
+	Hs
		396588 ITB3_HUMAN (4-788): 0: 716: 53.87		FAK2_HUMAN (35-1043): 0: 852: 44.78
+	Hs
		403881 ITB1_HUMAN (8-789): 0: 716: 41.68		FAK2_HUMAN (35-1043): 0: 852: 44.78
+	Hs
		396630 ITB2_HUMAN (27-787): 0: 645: 37.10		FAK2_HUMAN (35-1043): 0: 852: 44.78
+	Hs
		574501 ITB5_HUMAN (1-799): 0: 786: 100.00		EPHA2_HUMAN (369-774): 9.75e-117: 385: 30.73
+	Mm
		337617 ITB1_MOUSE (9-789): 0: 715: 41.10		ABL1_MOUSE (245-1017): 2.87e-121: 401: 21.44
+	Hs
		396569 ITB3_HUMAN (4-788): 0: 716: 53.87		EPHA2_HUMAN (369-774): 9.75e-117: 385: 30.73
+	Hs
		403793 ITB1_HUMAN (8-789): 0: 716: 41.68		EPHA2_HUMAN (369-774): 9.75e-117: 385: 30.73
+	Hs
		373504 ITB3_HUMAN (4-788): 0: 716: 53.87		RAF1_HUMAN (106-714): 1.08e-119: 383: 16.88
+	Hs
		373516 ITB1_HUMAN (8-789): 0: 716: 41.68		RAF1_HUMAN (106-714): 1.08e-119: 383: 16.88
+	Hs
		396558 ITB3_HUMAN (4-788): 0: 716: 53.87		FGFR1_HUMAN (331-734): 2.82e-114: 374: 27.64
+	Mm
		222493 ITB3_MOUSE (5-788): 0: 725: 53.17		SRC_MOUSE (415-689): 7.2e-113: 361: 38.41
+	Hs
		396559 ITB3_HUMAN (4-788): 0: 716: 53.87		SRC_HUMAN (415-689): 1.19e-113: 363: 38.77
+	Dm
		246709 TENM_DROME (597-733): 3.98e-15: 82.4: 16.79		ABL_DROME (272-964): 4.19e-119: 403: 22.86
+	Hs
		433503 TEN1_HUMAN (593-740): 2.25e-14: 79.8: 10.81		YES_HUMAN (415-689): 7.31e-112: 359: 37.68
+	Hs
		600692 TEN3_HUMAN (559-740): 5.88e-25: 114: 15.96		EPHA1_HUMAN (428-680): 4.6e-63: 234: 45.88