HitPredict

Interactor 1: PLCG1 (P19174)
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 (EC 3.1.4.11) (PLC-148) (Phosphoinositide phospholipase C-gamma-1) (Phospholipase C-II) (PLC-II) (Phospholipase C-gamma-1) (PLC-gamma-1)
Gene: PLCG1

Interactor 2: SOS2 (Q07890)
Son of sevenless homolog 2 (SOS-2)
Gene: SOS2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.72	1.00	0.852

Property	Details
Experiments	10940929, 17474147
Identification Methods	two hybrid, affinity chromatography technology, anti tag coimmunoprecipitation, peptide array, pull down, anti bait coimmunoprecipitation, fluorescence technology
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	PH~PH, PH~RhoGEF, PH~SH3_1, RhoGEF~SH3_1
Common GO terms	GO:0005085 - guanyl-nucleotide exchange factor activity GO:0005829 - cytosol GO:0005886 - plasma membrane
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 1290 Hs			1 1332
+	Hs
		580987 PLCG1_HUMAN (1-1290): 0: 1314: 100.00		SOS1_HUMAN (1-1330): 0: 913: 67.29
+	Mm
		1143290 PLCG1_MOUSE (1-1288): 0: 1302: 96.12		SOS1_MOUSE (1-1330): 0: 905: 67.34
+	Mm
		970656 PLCG2_MOUSE (19-1287): 0: 1131: 50.12		SOS2_MOUSE (1-1332): 0: 959: 94.97
+	Hs
		581036 PLCG1_HUMAN (1-1290): 0: 1314: 100.00		ARHG2_HUMAN (30-849): 9.08e-97: 335: 11.63
+	Hs
		548634 PLCG1_HUMAN (1-1290): 0: 1314: 100.00		VAV_HUMAN (51-665): 1.7e-84: 297: 13.44
+	Mm
		1143293 PLCG1_MOUSE (1-1288): 0: 1302: 96.12		RGPS2_MOUSE (772-1061): 7.38e-87: 297: 23.84
+	Hs
		581033 PLCG1_HUMAN (1-1290): 0: 1314: 100.00		RPGF5_HUMAN (610-1017): 6.86e-80: 276: 18.12
+	Hs
		548630 PLCG2_HUMAN (18-1287): 0: 1128: 49.45		VAV_HUMAN (51-665): 1.7e-84: 297: 13.44