HitPredict

Interactor 1: RPB3 (P19387)
DNA-directed RNA polymerase II subunit RPB3 (RNA polymerase II subunit 3) (RNA polymerase II subunit B3) (DNA-directed RNA polymerase II 33 kDa polypeptide) (RPB33) (DNA-directed RNA polymerase II subunit C) (RPB31)
Gene: POLR2C

Interactor 2: SPT6H (Q7KZ85)
Transcription elongation factor SPT6 (hSPT6) (Histone chaperone suppressor of Ty6) (Tat-cotransactivator 2 protein) (Tat-CT2 protein)
Gene: SUPT6H

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.60	0.611

Property	Details
Experiments	34079125, 18562274
Identification Methods	proximity labelling technology, affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003677 - DNA binding GO:0005654 - nucleoplasm
Homologous interactions	4

Homologous interactions

Color coding for hit scores

	1 275 Hs			1 1726
+	Sc
		557892 RPB3_YEAST (4-271): 9.52e-107: 313: 45.06		SPT6_YEAST (15-1512): 0: 812: 22.21
+	Hs
		169898 RPAC1_HUMAN (3-269): 1.2e-110: 325: 25.90		SRBD1_HUMAN (218-1212): 0: 597: 16.76
+	Hs
		583527 RPB3_HUMAN (1-275): 6.89e-138: 391: 100.00		LEO1_HUMAN (1-345): 1.27e-13: 78.1: 13.68
+	Sc
		558308 RPB3_YEAST (4-271): 9.52e-107: 313: 45.06		MDN1_YEAST (7-602): 7.28e-20: 99.7: 12.98