HitPredict

Interactor 1: TFE2 (P15923)
Transcription factor E2-alpha (Class B basic helix-loop-helix protein 21) (bHLHb21) (Immunoglobulin enhancer-binding factor E12/E47) (Immunoglobulin transcription factor 1) (Kappa-E2-binding factor) (Transcription factor 3) (TCF-3) (Transcription factor ITF-1)
Gene: TCF3

Interactor 2: NDF4 (Q9HD90)
Neurogenic differentiation factor 4 (NeuroD4) (Class A basic helix-loop-helix protein 4) (bHLHa4) (Protein atonal homolog 3) (ATH-3) (Atoh3)
Gene: NEUROD4

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.691

Property	Details
Experiments	33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	HLH~HLH
Common GO terms	GO:0000785 - chromatin GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific GO:0005634 - nucleus GO:0045944 - positive regulation of transcription by RNA polymerase II GO:0070888 - E-box binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 654 Hs			1 331
+	Hs
		587467 TFE2_HUMAN (1-654): 0: 907: 100.00		NDF1_HUMAN (1-331): 2.79e-89: 272: 51.69
+	Hs
		561205 TFE2_HUMAN (1-654): 0: 907: 100.00		MYF5_HUMAN (20-260): 4.12e-43: 150: 21.58
+	Hs
		587512 TFE2_HUMAN (1-654): 0: 907: 100.00		ATOH1_HUMAN (1-282): 9.61e-42: 150: 19.37
+	Hs
		581617 TFE2_HUMAN (1-654): 0: 907: 100.00		MYOD1_HUMAN (20-283): 3.49e-32: 123: 17.12
+	Hs
		587408 TFE2_HUMAN (1-654): 0: 907: 100.00		TFE2_HUMAN (14-189): 8.81e-30: 121: 15.82
+	Hs
		223955 TFE2_HUMAN (1-654): 0: 907: 100.00		TCF21_HUMAN (1-152): 7.55e-32: 119: 25.00
+	Hs
		587410 TFE2_HUMAN (1-654): 0: 907: 100.00		TAL1_HUMAN (67-231): 2.26e-28: 113: 25.30
+	Hs
		587460 TFE2_HUMAN (1-654): 0: 907: 100.00		MESP2_HUMAN (52-264): 1.45e-27: 113: 23.87
+	Hs
		587461 TFE2_HUMAN (1-654): 0: 907: 100.00		TCF15_HUMAN (20-207): 1.34e-29: 113: 22.75
+	Hs
		587494 TFE2_HUMAN (1-654): 0: 907: 100.00		TCF23_HUMAN (14-226): 1.62e-28: 111: 20.66
+	Hs
		587513 TFE2_HUMAN (1-654): 0: 907: 100.00		NGN1_HUMAN (29-227): 3.69e-28: 111: 28.50
+	Hs
		587517 TFE2_HUMAN (1-654): 0: 907: 100.00		FER3L_HUMAN (32-152): 3.34e-29: 111: 35.20
+	Hs
		558951 TFE2_HUMAN (1-654): 0: 907: 100.00		LYL1_HUMAN (54-216): 9.89e-27: 108: 23.93
+	Hs
		587507 TFE2_HUMAN (1-654): 0: 907: 100.00		TWST2_HUMAN (29-164): 5.13e-28: 108: 25.00
+	Hs
		587495 TFE2_HUMAN (1-654): 0: 907: 100.00		SCX_HUMAN (29-158): 1.21e-26: 106: 27.69
+	Hs
		587518 TFE2_HUMAN (1-654): 0: 907: 100.00		ATOH8_HUMAN (38-166): 1.53e-25: 106: 30.00
+	Hs
		587480 TFE2_HUMAN (1-654): 0: 907: 100.00		TAL2_HUMAN (86-207): 1.96e-27: 105: 29.51
+	Hs
		587491 TFE2_HUMAN (1-654): 0: 907: 100.00		BHA15_HUMAN (65-145): 3.72e-22: 93.7: 43.21
+	Hs
		253535 TFE2_HUMAN (1-654): 0: 907: 100.00		MUSC_HUMAN (76-151): 3.19e-21: 91.8: 36.84
+	Hs
		587466 TFE2_HUMAN (1-654): 0: 907: 100.00		OLIG2_HUMAN (74-144): 1.65e-09: 60.1: 53.43