HitPredict

Interactor 1: TFE2 (P15923)
Transcription factor E2-alpha (Class B basic helix-loop-helix protein 21) (bHLHb21) (Immunoglobulin enhancer-binding factor E12/E47) (Immunoglobulin transcription factor 1) (Kappa-E2-binding factor) (Transcription factor 3) (TCF-3) (Transcription factor ITF-1)
Gene: TCF3

Interactor 2: TAL2 (Q16559)
T-cell acute lymphocytic leukemia protein 2 (TAL-2) (Class A basic helix-loop-helix protein 19) (bHLHa19)
Gene: TAL2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.691

Property	Details
Experiments	33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	HLH~HLH
Common GO terms	GO:0000785 - chromatin GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific GO:0003677 - DNA binding GO:0006357 - regulation of transcription by RNA polymerase II
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 654 Hs			1 108
+	Hs
		587467 TFE2_HUMAN (1-654): 0: 907: 100.00		NDF1_HUMAN (3-107): 8.66e-28: 105: 33.03
+	Hs
		587525 TFE2_HUMAN (1-654): 0: 907: 100.00		NDF4_HUMAN (2-84): 3.27e-28: 105: 34.94
+	Hs
		587492 TFE2_HUMAN (1-654): 0: 907: 100.00		PTF1A_HUMAN (4-108): 1.68e-27: 103: 35.14
+	Hs
		587512 TFE2_HUMAN (1-654): 0: 907: 100.00		ATOH1_HUMAN (2-108): 3.9e-27: 103: 30.91
+	Hs
		587542 TFE2_HUMAN (1-654): 0: 907: 100.00		NGN3_HUMAN (2-104): 2.41e-27: 101: 33.01
+	Hs
		561205 TFE2_HUMAN (1-654): 0: 907: 100.00		MYF5_HUMAN (1-100): 1.39e-26: 100: 30.00
+	Hs
		587513 TFE2_HUMAN (1-654): 0: 907: 100.00		NGN1_HUMAN (2-106): 5.2e-27: 100: 31.43
+	Hs
		587436 TFE2_HUMAN (1-654): 0: 907: 100.00		HAND2_HUMAN (1-78): 2.17e-26: 98.9: 41.03
+	Hs
		587410 TFE2_HUMAN (1-654): 0: 907: 100.00		TAL1_HUMAN (1-104): 3.81e-25: 97.7: 47.41
+	Hs
		587461 TFE2_HUMAN (1-654): 0: 907: 100.00		TCF15_HUMAN (3-103): 4.5e-26: 97.4: 37.74
+	Hs
		558951 TFE2_HUMAN (1-654): 0: 907: 100.00		LYL1_HUMAN (1-108): 1.26e-24: 95.8: 47.22
+	Hs
		587477 TFE2_HUMAN (1-654): 0: 907: 100.00		TWST1_HUMAN (2-66): 6.28e-25: 94.7: 53.85
+	Hs
		223955 TFE2_HUMAN (1-654): 0: 907: 100.00		TCF21_HUMAN (2-62): 3.62e-25: 94.6: 40.98
+	Hs
		587418 TFE2_HUMAN (1-654): 0: 907: 100.00		MYF6_HUMAN (2-106): 1.93e-24: 94.3: 23.81
+	Hs
		587507 TFE2_HUMAN (1-654): 0: 907: 100.00		TWST2_HUMAN (2-66): 5.46e-25: 93.5: 52.31
+	Hs
		587517 TFE2_HUMAN (1-654): 0: 907: 100.00		FER3L_HUMAN (2-67): 4.76e-24: 91.6: 40.91
+	Hs
		587495 TFE2_HUMAN (1-654): 0: 907: 100.00		SCX_HUMAN (3-58): 1.77e-22: 88.5: 57.14
+	Hs
		587451 TFE2_HUMAN (1-654): 0: 907: 100.00		HEN2_HUMAN (9-58): 3.22e-22: 85.8: 66.00
+	Hs
		587450 TFE2_HUMAN (1-654): 0: 907: 100.00		HEN1_HUMAN (4-58): 6.61e-22: 85: 60.00
+	Hs
		354051 TFE2_HUMAN (1-654): 0: 907: 100.00		HAND1_HUMAN (3-65): 6.72e-21: 84.7: 47.62