HitPredict

Interactor 1: CXCL3 (P19876)
C-X-C motif chemokine 3 (GRO-gamma(1-73)) (Growth-regulated protein gamma) (GRO-gamma) (Macrophage inflammatory protein 2-beta) (MIP2-beta) [Cleaved into: GRO-gamma(5-73)]
Gene: CXCL3

Interactor 2: MMP12 (P39900)
Macrophage metalloelastase (MME) (EC 3.4.24.65) (Macrophage elastase) (ME) (hME) (Matrix metalloproteinase-12) (MMP-12)
Gene: MMP12

Species: Homo sapiens

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.60	0.501

Property	Details
Experiments	18660381
Identification Methods	protease assay
Interaction Type	protein cleavage

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005576 - extracellular region GO:0005615 - extracellular space
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 107 Hs			1 470
+	Hs
		587770 CXCL2_HUMAN (1-107): 2.01e-33: 113: 87.85		MMP12_HUMAN (1-470): 0: 665: 100.00
+	Hs
		448989 GROA_HUMAN (1-107): 2.59e-31: 108: 86.92		MMP12_HUMAN (1-470): 0: 665: 100.00
+	Hs
		364043 CXCL7_HUMAN (25-106): 4.34e-28: 100: 45.12		MMP12_HUMAN (1-470): 0: 665: 100.00
+	Hs
		764724 CXCL5_HUMAN (30-105): 2.87e-26: 95.5: 48.68		MMP12_HUMAN (1-470): 0: 665: 100.00
+	Hs
		764727 CXCL6_HUMAN (30-105): 6.17e-25: 92.1: 42.11		MMP12_HUMAN (1-470): 0: 665: 100.00
+	Hs
		372731 CXCL2_HUMAN (1-107): 2.01e-33: 113: 87.85		MMP1_HUMAN (11-470): 0: 608: 49.24
+	Hs
		364034 CXCL7_HUMAN (25-106): 4.34e-28: 100: 45.12		MMP1_HUMAN (11-470): 0: 608: 49.24
+	Hs
		372733 CXCL5_HUMAN (30-105): 2.87e-26: 95.5: 48.68		MMP1_HUMAN (11-470): 0: 608: 49.24
+	Mm
		500671 CXCL2_MOUSE (9-107): 3.12e-32: 110: 64.65		MMP12_MOUSE (1-470): 0: 593: 61.78
+	Hs
		372737 CXCL6_HUMAN (30-105): 6.17e-25: 92.1: 42.11		MMP1_HUMAN (11-470): 0: 608: 49.24
+	Hs
		372724 IL8_HUMAN (30-107): 9.65e-25: 91.3: 37.98		MMP1_HUMAN (11-470): 0: 608: 49.24
+	Mm
		714631 CXCL3_MOUSE (9-107): 7.13e-31: 106: 56.57		MMP12_MOUSE (1-470): 0: 593: 61.78
+	Mm
		714630 CXCL5_MOUSE (7-105): 1.36e-28: 102: 41.58		MMP12_MOUSE (1-470): 0: 593: 61.78
+	Hs
		612139 CXCL5_HUMAN (30-105): 2.87e-26: 95.5: 48.68		MMP8_HUMAN (13-470): 0: 599: 47.16
+	Mm
		522396 GROA_MOUSE (33-103): 1.4e-26: 95.9: 66.20		MMP12_MOUSE (1-470): 0: 593: 61.78
+	Hs
		540414 CXCL2_HUMAN (1-107): 2.01e-33: 113: 87.85		MMP9_HUMAN (12-206): 2.35e-72: 243: 36.77
+	Hs
		364037 CXCL7_HUMAN (25-106): 4.34e-28: 100: 45.12		MMP9_HUMAN (12-206): 2.35e-72: 243: 36.77
+	Hs
		540419 CXCL5_HUMAN (30-105): 2.87e-26: 95.5: 48.68		MMP9_HUMAN (12-206): 2.35e-72: 243: 36.77
+	Hs
		540420 CXCL6_HUMAN (30-105): 6.17e-25: 92.1: 42.11		MMP9_HUMAN (12-206): 2.35e-72: 243: 36.77
+	Hs
		486175 IL8_HUMAN (30-107): 9.65e-25: 91.3: 37.98		MMP9_HUMAN (12-206): 2.35e-72: 243: 36.77