HitPredict

Interactor 1: GBB3 (P16520)
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 (Transducin beta chain 3)
Gene: GNB3

Interactor 2: GBG3 (P63215)
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3
Gene: GNG3

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.57	0.60	0.586

Property	Details
Experiments	8636150, 19168127
Identification Methods	two hybrid, affinity chromatography technology
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003924 - GTPase activity GO:0005834 - heterotrimeric G-protein complex GO:0005886 - plasma membrane GO:0007186 - G protein-coupled receptor signaling pathway GO:0030425 - dendrite and 1 others more... GO:0044297 - cell body
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 340 Hs			1 75
+	Hs
		597345 GBB3_HUMAN (1-340): 1.78e-107: 319: 100.00		GBG4_HUMAN (1-75): 4.63e-29: 100: 69.33
+	Hs
		597349 GBB3_HUMAN (1-340): 1.78e-107: 319: 100.00		GBG2_HUMAN (5-75): 2.65e-28: 98.2: 76.06
+	Hs
		893551 GBB2_HUMAN (1-340): 1.87e-104: 311: 78.49		GBG4_HUMAN (1-75): 4.63e-29: 100: 69.33
+	Hs
		948052 GBB2_HUMAN (1-340): 1.87e-104: 311: 78.49		GBG2_HUMAN (5-75): 2.65e-28: 98.2: 76.06
+	Hs
		243464 GBB3_HUMAN (1-340): 1.78e-107: 319: 100.00		GBG7_HUMAN (7-75): 5.92e-25: 89.3: 60.87
+	Hs
		597377 GBB3_HUMAN (1-340): 1.78e-107: 319: 100.00		GBG8_HUMAN (7-75): 6.38e-25: 89.3: 56.52
+	Hs
		597375 GBB3_HUMAN (1-340): 1.78e-107: 319: 100.00		GBG12_HUMAN (8-75): 1.13e-23: 86.3: 60.29
+	Hs
		597346 GBB3_HUMAN (1-340): 1.78e-107: 319: 100.00		GBG10_HUMAN (7-75): 2.49e-22: 82.8: 50.73
+	Hs
		243467 GBB2_HUMAN (1-340): 1.87e-104: 311: 78.49		GBG7_HUMAN (7-75): 5.92e-25: 89.3: 60.87
+	Hs
		597354 GBB3_HUMAN (1-340): 1.78e-107: 319: 100.00		GBG5_HUMAN (7-75): 1.43e-21: 80.9: 46.38
+	Hs
		597352 GBB3_HUMAN (1-340): 1.78e-107: 319: 100.00		GBG1_HUMAN (5-74): 5.38e-20: 77: 32.88
+	Hs
		893565 GBB2_HUMAN (1-340): 1.87e-104: 311: 78.49		GBG10_HUMAN (7-75): 2.49e-22: 82.8: 50.73
+	Hs
		597374 GBB3_HUMAN (1-340): 1.78e-107: 319: 100.00		GBG13_HUMAN (12-75): 4.34e-18: 72: 29.69
+	Hs
		984063 GBB2_HUMAN (1-340): 1.87e-104: 311: 78.49		GBG1_HUMAN (5-74): 5.38e-20: 77: 32.88
+	Hs
		992415 Q6FHM2_HUMAN (1-340): 1.87e-104: 311: 78.49		GBG1_HUMAN (5-74): 5.38e-20: 77: 32.88
+	Hs
		597350 GBB3_HUMAN (1-340): 1.78e-107: 319: 100.00		GBG11_HUMAN (5-74): 9.47e-16: 66.2: 31.51
+	Hs
		158706 GBB3_HUMAN (1-340): 1.78e-107: 319: 100.00		GBGT2_HUMAN (16-74): 1.42e-15: 65.8: 38.98
+	Hs
		158713 GBB2_HUMAN (1-340): 1.87e-104: 311: 78.49		GBGT2_HUMAN (16-74): 1.42e-15: 65.8: 38.98
+	Ce
		111110 GBB1_CAEEL (1-340): 1.56e-104: 311: 81.47		G5ECT6_CAEEL (11-75): 4.38e-14: 62: 27.69
+	Ce
		604386 GBB1_CAEEL (1-340): 1.56e-104: 311: 81.47		GBG_CAEEL (16-75): 7.73e-14: 61.2: 35.00