HitPredict

Interactor 1: GBG10 (P50151)
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10
Gene: GNG10

Interactor 2: GBB2 (P62879)
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 (G protein subunit beta-2) (Transducin beta chain 2)
Gene: GNB2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.83	0.60	0.709

Property	Details
Experiments	33961781, 19168127, 7665596, 19376773, unassigned3799
Identification Methods	affinity chromatography technology, pull down, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003924 - GTPase activity GO:0005834 - heterotrimeric G-protein complex GO:0005886 - plasma membrane GO:0007186 - G protein-coupled receptor signaling pathway
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 68 Hs			1 340
+	Hs
		243467 GBG7_HUMAN (1-68): 1.09e-27: 96.2: 52.94		GBB2_HUMAN (1-340): 3.43e-110: 326: 100.00
+	Hs
		243474 GBG7_HUMAN (1-68): 1.09e-27: 96.2: 52.94		GBB4_HUMAN (1-340): 7.17e-109: 322: 90.00
+	Hs
		984316 GBG12_HUMAN (2-68): 5.43e-26: 92: 44.78		GBB2_HUMAN (1-340): 3.43e-110: 326: 100.00
+	Hs
		948052 GBG2_HUMAN (2-68): 6.58e-26: 91.6: 52.94		GBB2_HUMAN (1-340): 3.43e-110: 326: 100.00
+	Hs
		984064 GBG3_HUMAN (1-68): 1.31e-25: 90.9: 50.73		GBB2_HUMAN (1-340): 3.43e-110: 326: 100.00
+	Hs
		1437752 GBG12_HUMAN (2-68): 5.43e-26: 92: 44.78		GBB4_HUMAN (1-340): 7.17e-109: 322: 90.00
+	Hs
		948081 GBG2_HUMAN (2-68): 6.58e-26: 91.6: 52.94		GBB4_HUMAN (1-340): 7.17e-109: 322: 90.00
+	Hs
		243464 GBG7_HUMAN (1-68): 1.09e-27: 96.2: 52.94		GBB3_HUMAN (1-340): 3.82e-105: 313: 80.88
+	Hs
		243466 GBG7_HUMAN (1-68): 1.09e-27: 96.2: 52.94		GBB1_HUMAN (1-340): 2.39e-105: 313: 90.29
+	Hs
		597375 GBG12_HUMAN (2-68): 5.43e-26: 92: 44.78		GBB3_HUMAN (1-340): 3.82e-105: 313: 80.88
+	Hs
		983605 GBG12_HUMAN (2-68): 5.43e-26: 92: 44.78		GBB1_HUMAN (1-340): 2.39e-105: 313: 90.29
+	Hs
		597349 GBG2_HUMAN (2-68): 6.58e-26: 91.6: 52.94		GBB3_HUMAN (1-340): 3.82e-105: 313: 80.88
+	Hs
		948051 GBG2_HUMAN (2-68): 6.58e-26: 91.6: 52.94		GBB1_HUMAN (1-340): 2.39e-105: 313: 90.29
+	Bt
		983440 GBG2_BOVIN (2-68): 6.58e-26: 91.6: 52.94		GBB1_BOVIN (1-340): 2.39e-105: 313: 90.29
+	Mm
		983624 GBG2_MOUSE (2-68): 6.58e-26: 91.6: 52.94		GBB1_MOUSE (1-340): 2.39e-105: 313: 90.29
+	Hs
		597353 GBG3_HUMAN (1-68): 1.31e-25: 90.9: 50.73		GBB3_HUMAN (1-340): 3.82e-105: 313: 80.88
+	Hs
		983447 GBG3_HUMAN (1-68): 1.31e-25: 90.9: 50.73		GBB1_HUMAN (1-340): 2.39e-105: 313: 90.29
+	Hs
		163603 GBG7_HUMAN (1-68): 1.09e-27: 96.2: 52.94		GNB5_HUMAN (129-340): 7.58e-44: 157: 20.81
+	Hs
		163627 GBG2_HUMAN (2-68): 6.58e-26: 91.6: 52.94		GNB5_HUMAN (129-340): 7.58e-44: 157: 20.81
+	Hs
		163629 GBG3_HUMAN (1-68): 1.31e-25: 90.9: 50.73		GNB5_HUMAN (129-340): 7.58e-44: 157: 20.81