HitPredict

Interactor 1: FLNA (P21333)
Filamin-A (FLN-A) (Actin-binding protein 280) (ABP-280) (Alpha-filamin) (Endothelial actin-binding protein) (Filamin-1) (Non-muscle filamin)
Gene: FLNA

Interactor 2: ACTA (P62736)
Actin, aortic smooth muscle (EC 3.6.4.-) (Alpha-actin-2) (Cell growth-inhibiting gene 46 protein) [Cleaved into: Actin, aortic smooth muscle, intermediate form]
Gene: ACTA2

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	37071682
Identification Methods	cross-linking study
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Actin~CH
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0070062 - extracellular exosome
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 2647 Hs			1 377
+	Hs
		598031 FLNA_HUMAN (1-2647): 0: 2776: 100.00		ACTB_HUMAN (4-377): 0: 598: 94.12
+	Hs
		598053 FLNA_HUMAN (1-2647): 0: 2776: 100.00		ACTG_HUMAN (4-377): 0: 598: 94.39
+	Hs
		598055 FLNA_HUMAN (1-2647): 0: 2776: 100.00		ACTC_HUMAN (1-377): 0: 598: 98.41
+	Hs
		261242 FLNB_HUMAN (28-2647): 0: 2710: 69.63		ACTC_HUMAN (1-377): 0: 598: 98.41
+	Hs
		261239 FLNB_HUMAN (28-2647): 0: 2710: 69.63		ACTA_HUMAN (1-377): 0: 596: 100.00
+	Mm
		892189 FLNB_MOUSE (28-2647): 0: 2675: 68.91		ACTB_MOUSE (4-377): 0: 598: 94.12
+	Hs
		891763 FLNC_HUMAN (32-2647): 0: 1432: 35.96		ACTB_HUMAN (4-377): 0: 598: 94.12
+	Hs
		891697 SPTB2_HUMAN (22-460): 2.2e-118: 423: 24.62		ACTB_HUMAN (4-377): 0: 598: 94.12
+	Hs
		929824 SPTB2_HUMAN (22-460): 2.2e-118: 423: 24.62		ACTG_HUMAN (4-377): 0: 598: 94.39
+	Hs
		932107 SPTB2_HUMAN (22-460): 2.2e-118: 423: 24.62		ACTC_HUMAN (1-377): 0: 598: 98.41
+	Hs
		506816 SPTB1_HUMAN (2-460): 2.89e-117: 419: 23.57		ACTB_HUMAN (4-377): 0: 598: 94.12
+	Hs
		725637 ACTN2_HUMAN (6-459): 1.76e-121: 410: 23.62		ACTB_HUMAN (4-377): 0: 598: 94.12
+	Dm
		361167 ACTN_DROME (22-268): 2.24e-102: 354: 33.47		ACT4_DROME (1-377): 0: 647: 92.04
+	Hs
		211548 ACTN4_HUMAN (23-382): 4.2e-112: 383: 27.01		ACTB_HUMAN (4-377): 0: 598: 94.12
+	Hs
		211560 ACTN4_HUMAN (23-382): 4.2e-112: 383: 27.01		ACTC_HUMAN (1-377): 0: 598: 98.41
+	Hs
		211561 ACTN4_HUMAN (23-382): 4.2e-112: 383: 27.01		ACTS_HUMAN (1-377): 0: 598: 97.88
+	Dm
		284844 O77291_DROME (7-281): 5.87e-104: 376: 33.09		ACT1_DROME (1-377): 0: 597: 93.90
+	Oc
		933099 Q07931_RABIT (30-292): 1.85e-111: 358: 34.08		ACTS_RABIT (1-377): 0: 598: 97.88