HitPredict

Interactor 1: CLH (P22137)
Clathrin heavy chain
Gene: CHC1

Interactor 2: ENT1 (Q12518)
Epsin-1
Gene: ENT1

Species: Saccharomyces cerevisiae S288C

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.77	0.60	0.683

Property	Details
Experiments	32400111, 14704157, 10449404, 12529323
Identification Methods	fluorescent resonance energy transfer, affinity chromatography technology, pull down
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0006897 - endocytosis GO:0030125 - clathrin vesicle coat
Homologous interactions	12

Homologous interactions

Color coding for hit scores

	1 1653 Sc			1 454
+	Hs
		961040 CLH1_HUMAN (4-1648): 0: 2909: 49.76		EPN1_HUMAN (2-454): 2.22e-107: 331: 21.10
+	Hs
		960794 CLH1_HUMAN (4-1648): 0: 2909: 49.76		EPN4_HUMAN (3-442): 1.21e-104: 325: 18.93
+	Rn
		291386 CLH1_RAT (4-1648): 0: 2901: 49.76		EPN1_RAT (2-454): 5.12e-108: 332: 20.69
+	Hs
		307526 CLH1_HUMAN (4-1648): 0: 2909: 49.76		EPN2_HUMAN (2-426): 2.3e-101: 317: 22.87
+	Dm
		669592 CLH_DROME (4-1650): 0: 2804: 48.58		Q7KU90_DROME (5-446): 5e-91: 295: 25.71
+	Hs
		863938 CLH2_HUMAN (4-1635): 0: 2773: 48.90		EPN4_HUMAN (3-442): 1.21e-104: 325: 18.93
+	Bt
		836912 CLH1_BOVIN (4-1648): 0: 2909: 49.76		AUXI_BOVIN (134-454): 1.67e-11: 68.7: 10.73
+	At
		1012797 CLAH1_ARATH (2-1642): 0: 2628: 43.39		EPN1_ARATH (3-454): 2.49e-96: 302: 17.34
+	At
		1012719 CLAH2_ARATH (2-1635): 0: 2640: 43.64		EPN2_ARATH (3-439): 4.63e-82: 272: 19.92
+	Sc
		604440 CLH_YEAST (1-1653): 0: 2506: 100.00		ENT3_YEAST (2-382): 8.98e-88: 275: 19.80
+	Sc
		604463 CLH_YEAST (1-1653): 0: 2506: 100.00		ENT5_YEAST (3-352): 1.37e-62: 210: 13.92
+	Sc
		604473 CLH_YEAST (1-1653): 0: 2506: 100.00		ENT2_YEAST (340-447): 1.08e-16: 84.5: 75.00