Protein: NECP2
Adaptin ear-binding coat-associated protein 2 (NECAP endocytosis-associated protein 2) (NECAP-2)

Gene: NECP2, NECAP2
Organism: Homo sapiens
Interactions: 58
UniProt ID: Q9NVZ3

Gene Ontology (top 5):
GO:0005886 - plasma membrane
GO:0005905 - clathrin-coated pit
GO:0006897 - endocytosis
GO:0015031 - protein transport
GO:0016192 - vesicle-mediated transport

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1386719

AP2M1
AP-2 complex subunit mu

6

4

High-throughput

0.950

High

989137

AP2B1
AP-2 complex subunit beta

5

12

High-throughput

0.934

High

323791

AP2A2
AP-2 complex subunit alpha-2

4

12

High-throughput

0.903

High

344811

AP2A1
AP-2 complex subunit alpha-1

4

12

High-throughput

0.903

High

1083323

AP1B1
AP-1 complex subunit beta-1

4

12

High-throughput

0.903

High

225856

AP1G1
AP-1 complex subunit gamma-1

3

12

Small-scale

0.847

High

922615

AP2S1
AP-2 complex subunit sigma

5

6

High-throughput

0.716

High

1335274

NECP1
Adaptin ear-binding coat-associated protein 1

3

0

High-throughput

0.638

High

1450996

TES
Testin

3

0

High-throughput

0.638

High

839835

EPS15
Epidermal growth factor receptor substrate 15

2

5

High-throughput

0.628

High

1417315

AP1M1
AP-1 complex subunit mu-1

1

4

High-throughput

0.618

High

1154180

ITSN1
Intersectin-1

2

5

High-throughput

0.611

High

187410

SHIP2
Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2

1

2

High-throughput

0.536

High

1178796

AAK1
AP2-associated protein kinase 1

1

1

High-throughput

0.536

High

1450993

EP15R
Epidermal growth factor receptor substrate 15-like 1

1

5

High-throughput

0.536

High

180604

PLS1
Phospholipid scramblase 1

1

0

High-throughput

0.518

High

389539

FINC
Fibronectin

1

0

High-throughput

0.513

High

1288020

YRDC
Threonylcarbamoyl-AMP synthase

1

0

High-throughput

0.513

High

423304

A4
Amyloid-beta precursor protein

1

1

High-throughput

0.501

High

1219199

SPAT1
Spermatogenesis-associated protein 1

1

1

High-throughput

0.489

High

1449477

BMP2K
BMP-2-inducible protein kinase

1

1

High-throughput

0.489

High

791773

SYUA
Alpha-synuclein

1

1

High-throughput

0.481

High

346408

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

2

High-throughput

0.479

High

612317

ARF4
ADP-ribosylation factor 4

1

1

High-throughput

0.479

High

1015140

ARF5
ADP-ribosylation factor 5

1

1

High-throughput

0.479

High

1434040

PKHA4
Pleckstrin homology domain-containing family A member 4

1

2

High-throughput

0.479

High

1450997

UBQL2
Ubiquilin-2

1

1

High-throughput

0.479

High

541715

FGFR1
Fibroblast growth factor receptor 1

1

0

High-throughput

0.458

High

159880

DVL2
Segment polarity protein dishevelled homolog DVL-2

1

1

High-throughput

0.437

High

986763

PPIA
Peptidyl-prolyl cis-trans isomerase A

1

1

High-throughput

0.437

High

1211007

CE170
Centrosomal protein of 170 kDa

1

1

High-throughput

0.437

High

1450998

GGA2
ADP-ribosylation factor-binding protein GGA2

1

3

Small-scale

0.437

High

1450999

GGA1
ADP-ribosylation factor-binding protein GGA1

1

3

Small-scale

0.437

High

404928

PRIO
Major prion protein

1

0

High-throughput

0.426

High

177316

ANR28
Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A

3

0

High-throughput

0.347

High

1293425

CARM1
Histone-arginine methyltransferase CARM1

3

0

High-throughput

0.347

High

1421068

ZY11B
Protein zyg-11 homolog B

3

0

High-throughput

0.347

High

1202504

RUN3A
RUN domain-containing protein 3A

2

0

High-throughput

0.328

High

1090949

TRAF2
TNF receptor-associated factor 2

1

0

High-throughput

0.282

High

1101245

NMI
N-myc-interactor

1

0

High-throughput

0.282

High

602841

AATC
Aspartate aminotransferase, cytoplasmic

1

0

High-throughput

0.279

Low

1349995

PHOP1
Phosphoethanolamine/phosphocholine phosphatase

1

0

High-throughput

0.279

Low

1400487

SMG1
Serine/threonine-protein kinase SMG1

1

0

High-throughput

0.279

Low

1438622

GLOD4
Glyoxalase domain-containing protein 4

1

0

High-throughput

0.279

Low

1450675

EVA1B
Protein eva-1 homolog B

1

0

High-throughput

0.279

Low

1450994

GHRL
Appetite-regulating hormone

1

0

High-throughput

0.279

Low

106732

APRIO
Alternative prion protein

1

0

High-throughput

0.249

Low

243099

PRKN
E3 ubiquitin-protein ligase parkin

1

0

High-throughput

0.249

Low

589844

RFA2
Replication protein A 32 kDa subunit

1

0

High-throughput

0.249

Low

769330

RFA3
Replication protein A 14 kDa subunit

1

0

High-throughput

0.249

Low

879525

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

0

High-throughput

0.249

Low

1104270

DC1I2
Cytoplasmic dynein 1 intermediate chain 2

1

0

High-throughput

0.249

Low

1108205

SQSTM
Sequestosome-1

1

0

High-throughput

0.249

Low

1256611

CE128
Centrosomal protein of 128 kDa

1

0

High-throughput

0.249

Low

1276863

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

0

High-throughput

0.249

Low

1293825

FBX11
F-box only protein 11

1

0

High-throughput

0.249

Low

1399105

SCLT1
Sodium channel and clathrin linker 1

1

0

High-throughput

0.249

Low

1450995

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025