HitPredict

Interactor 1: KAPCA (P17612)
cAMP-dependent protein kinase catalytic subunit alpha (PKA C-alpha) (EC 2.7.11.11)
Gene: PRKACA

Interactor 2: KAPCB (P22694)
cAMP-dependent protein kinase catalytic subunit beta (PKA C-beta) (EC 2.7.11.11)
Gene: PRKACB

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.95 1.00 0.977

The method score is based on:

Property Details
Experiments 33957083, 35271311, 32707033, 30274258, 35575683, 38334954, 23455922, 28514442, 24981860, 33961781, unassigned3799
Identification Methods affinity chromatography technology, cross-linking study, pull down, anti tag coimmunoprecipitation, tandem affinity purification
Interaction Type physical association, association

The annotation score is based on:

Property Details
Interacting Pfam domains Pkinase~Pkinase
Common GO terms GO:0000287 - magnesium ion binding
GO:0001843 - neural tube closure
GO:0003091 - renal water homeostasis
GO:0004674 - protein serine/threonine kinase activity
GO:0004691 - cAMP-dependent protein kinase activity
and 18 others

more...
Homologous interactions 14

Homologous interactions

Color coding for hit scores

1 351
Hs

1 351
+ Hs
+ Hs
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+ Hs
+ Dm
+ Hs
+ Hs
+ Hs
+ Mm
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+ Mm
+ Hs
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+ Ce

Service provided by Combinatics, Japan

Last updated: 11Aug2025