HitPredict

Interactor 1: UBA1 (P22314)
Ubiquitin-like modifier-activating enzyme 1 (EC 6.2.1.45) (Protein A1S9) (Ubiquitin-activating enzyme E1)
Gene: UBA1

Interactor 2: UB2R1 (P49427)
Ubiquitin-conjugating enzyme E2 R1 (EC 2.3.2.23) ((E3-independent) E2 ubiquitin-conjugating enzyme R1) (EC 2.3.2.24) (E2 ubiquitin-conjugating enzyme R1) (Ubiquitin-conjugating enzyme E2-32 kDa complementing) (Ubiquitin-conjugating enzyme E2-CDC34) (Ubiquitin-protein ligase R1)
Gene: CDC34

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.89 1.00 0.946

The method score is based on:

Property Details
Experiments 25527291, 30097011, 36758106, 22069333, 17597759, 24912152
Identification Methods enzymatic study, pull down
Interaction Type direct interaction

The annotation score is based on:

Property Details
Interacting Pfam domains E1_UFD~UQ_con, ThiF~UQ_con
Common GO terms GO:0005524 - ATP binding
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005829 - cytosol
GO:0006511 - ubiquitin-dependent protein catabolic process
and 1 others

more...
Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 1058
Hs

1 236
+ Hs
+ Oc
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Sp
+ Sp
+ Sc
+ Sp
+ Sc
+ Sc
+ Hs
+ Hs
+ Sp
+ Sp

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024