HitPredict

Interactor 1: CBL (P22681)
E3 ubiquitin-protein ligase CBL (EC 2.3.2.27) (Casitas B-lineage lymphoma proto-oncogene) (Proto-oncogene c-Cbl) (RING finger protein 55) (RING-type E3 ubiquitin transferase CBL) (Signal transduction protein CBL)
Gene: CBL

Interactor 2: BLK (P51451)
Tyrosine-protein kinase Blk (EC 2.7.10.2) (B lymphocyte kinase) (p55-Blk)
Gene: BLK

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.44	0.60	0.515

Property	Details
Experiments	8621719
Identification Methods	affinity chromatography technology, coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 906 Hs			1 505
+	Hs
		442780 CBL_HUMAN (1-906): 0: 917: 100.00		HCK_HUMAN (1-505): 0: 574: 62.92
+	Hs
		411595 CBL_HUMAN (1-906): 0: 917: 100.00		LCK_HUMAN (1-505): 0: 569: 59.15
+	Hs
		412013 CBL_HUMAN (1-906): 0: 917: 100.00		FYN_HUMAN (1-503): 0: 562: 54.75
+	Hs
		522778 CBL_HUMAN (1-906): 0: 917: 100.00		SRC_HUMAN (1-503): 0: 560: 54.22
+	Hs
		433254 CBL_HUMAN (1-906): 0: 917: 100.00		YES_HUMAN (1-503): 0: 555: 53.15
+	Hs
		433577 CBL_HUMAN (1-906): 0: 917: 100.00		LYN_HUMAN (1-505): 0: 551: 59.77
+	Hs
		454799 CBL_HUMAN (1-906): 0: 917: 100.00		FGR_HUMAN (1-503): 0: 550: 53.61
+	Mm
		411917 CBL_MOUSE (1-906): 0: 888: 91.59		LCK_MOUSE (1-505): 0: 577: 59.35
+	Mm
		435877 CBL_MOUSE (1-906): 0: 888: 91.59		HCK_MOUSE (1-505): 0: 564: 61.93
+	Mm
		536206 CBL_MOUSE (1-906): 0: 888: 91.59		FGR_MOUSE (1-503): 0: 562: 55.13
+	Mm
		610554 CBL_MOUSE (1-906): 0: 888: 91.59		FYN_MOUSE (1-503): 0: 561: 54.56
+	Mm
		403415 CBL_MOUSE (1-906): 0: 888: 91.59		SRC_MOUSE (1-503): 0: 557: 54.51
+	Mm
		610545 CBL_MOUSE (1-906): 0: 888: 91.59		LYN_MOUSE (1-505): 0: 554: 60.16
+	Hs
		610281 CBL_HUMAN (1-906): 0: 917: 100.00		ABL2_HUMAN (8-503): 2.23e-165: 500: 38.67
+	Hs
		337348 CBL_HUMAN (1-906): 0: 917: 100.00		ABL1_HUMAN (54-504): 6.77e-163: 492: 41.09
+	Hs
		69201 CBL_HUMAN (1-906): 0: 917: 100.00		A9UF07_HUMAN (54-504): 8.4e-157: 490: 41.09
+	Hs
		610373 CBL_HUMAN (1-906): 0: 917: 100.00		ITK_HUMAN (29-496): 7.21e-159: 466: 36.18
+	Mm
		337618 CBL_MOUSE (1-906): 0: 888: 91.59		ABL1_MOUSE (54-504): 4.64e-163: 493: 41.30
+	Hs
		610368 CBL_HUMAN (1-906): 0: 917: 100.00		BTK_HUMAN (4-498): 2.89e-156: 461: 34.12
+	Hs
		610276 CBL_HUMAN (1-906): 0: 917: 100.00		CSK_HUMAN (51-495): 1.16e-155: 452: 36.54