Protein: UBP13
Ubiquitin carboxyl-terminal hydrolase 13 (EC 3.4.19.12) (Deubiquitinating enzyme 13) (Isopeptidase T-3) (ISOT-3) (Ubiquitin thioesterase 13) (Ubiquitin-specific-processing protease 13)

Gene: UBP13, USP13
Organism: Homo sapiens
Interactions: 109
UniProt ID: Q92995

Gene Ontology (top 5):
GO:0004197 - cysteine-type endopeptidase activity
GO:0004843 - cysteine-type deubiquitinase activity
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005829 - cytosol

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

508376

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

9

20

Small-scale

0.969

High

856845

BAG6
Large proline-rich protein BAG6

3

10

Small-scale

0.853

High

543251

UBL4A
Ubiquitin-like protein 4A

2

20

Small-scale

0.834

High

853503

UBP5
Ubiquitin carboxyl-terminal hydrolase 5

2

16

Small-scale

0.776

High

889781

CLK3
Dual specificity protein kinase CLK3

1

6

Small-scale

0.747

High

951795

PTEN
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

6

8

Small-scale

0.741

High

997917

CSK21
Casein kinase II subunit alpha

1

3

Small-scale

0.724

High

1130136

SMC1A
Structural maintenance of chromosomes protein 1A

5

2

Small-scale

0.718

High

238581

RAD21
Double-strand-break repair protein rad21 homolog

5

1

Small-scale

0.712

High

1115876

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1

8

High-throughput

0.698

High

1371388

SMC3
Structural maintenance of chromosomes protein 3

4

2

Small-scale

0.694

High

1060279

MCL1
Induced myeloid leukemia cell differentiation protein Mcl-1

4

2

Small-scale

0.692

High

1154893

NEDD8
Ubiquitin-like protein NEDD8

1

12

High-throughput

0.691

High

1334304

SCPDL
Saccharopine dehydrogenase-like oxidoreductase

4

0

High-throughput

0.661

High

1371378

CYLD
Ubiquitin carboxyl-terminal hydrolase CYLD

1

0

High-throughput

0.656

High

1371371

RPP25
Ribonuclease P protein subunit p25

3

0

High-throughput

0.638

High

1371365

TRI63
E3 ubiquitin-protein ligase TRIM63

2

20

Small-scale

0.629

High

1371374

TRI55
Tripartite motif-containing protein 55

2

20

Small-scale

0.629

High

764942

CTNB1
Catenin beta-1

2

11

Small-scale

0.624

High

927086

ATX3
Ataxin-3

2

2

High-throughput

0.621

High

170267

AURKA
Aurora kinase A

1

17

Small-scale

0.618

High

920163

PLK1
Serine/threonine-protein kinase PLK1

1

18

High-throughput

0.618

High

931575

RD23A
UV excision repair protein RAD23 homolog A

1

18

Small-scale

0.618

High

1227201

A16L1
Autophagy-related protein 16-1

1

10

High-throughput

0.618

High

1359868

PRP31
U4/U6 small nuclear ribonucleoprotein Prp31

1

3

Small-scale

0.618

High

1371382

UBQL2
Ubiquilin-2

1

8

High-throughput

0.618

High

1035421

ODO1
2-oxoglutarate dehydrogenase complex component E1

2

1

Small-scale

0.611

High

1139097

DAZP2
DAZ-associated protein 2

2

1

High-throughput

0.606

High

1371380

DDX28
Probable ATP-dependent RNA helicase DDX28

2

8

High-throughput

0.601

High

1371370

UIMC1
BRCA1-A complex subunit RAP80

2

0

Small-scale

0.598

High

1371381

TRPC4
Short transient receptor potential channel 4

1

1

High-throughput

0.595

High

1369972

UFD1
Ubiquitin recognition factor in ER-associated degradation protein 1

2

0

Small-scale

0.585

High

1177615

PDS5A
Sister chromatid cohesion protein PDS5 homolog A

2

1

Small-scale

0.584

High

1325370

STAG2
Cohesin subunit SA-2

2

1

Small-scale

0.584

High

1151970

TWST1
Twist-related protein 1

1

4

Small-scale

0.578

High

1094602

UBP4
Ubiquitin carboxyl-terminal hydrolase 4

1

17

High-throughput

0.575

High

1110523

KCC2D
Calcium/calmodulin-dependent protein kinase type II subunit delta

1

1

High-throughput

0.575

High

211586

SIAH2
E3 ubiquitin-protein ligase SIAH2

1

20

Small-scale

0.561

High

664785

CCND1
G1/S-specific cyclin-D1

1

10

Small-scale

0.561

High

934957

TERA
Transitional endoplasmic reticulum ATPase

1

2

Small-scale

0.561

High

1107995

SQSTM
Sequestosome-1

1

8

Small-scale

0.561

High

1129677

MDC1
Mediator of DNA damage checkpoint protein 1

1

7

Small-scale

0.561

High

1364193

TOPB1
DNA topoisomerase 2-binding protein 1

1

5

Small-scale

0.561

High

1371384

AMFR
E3 ubiquitin-protein ligase AMFR

1

7

Small-scale

0.561

High

1279214

WAPL
Wings apart-like protein homolog

2

0

Small-scale

0.559

High

1371375

ATG5
Autophagy protein 5

1

0

Small-scale

0.554

High

159383

DVL1
Segment polarity protein dishevelled homolog DVL-1

1

5

High-throughput

0.541

High

1211646

FBP1L
Formin-binding protein 1-like

1

3

High-throughput

0.541

High

1371372

FUND2
FUN14 domain-containing protein 2

1

1

High-throughput

0.541

High

193295

SOCS1
Suppressor of cytokine signaling 1

1

4

High-throughput

0.536

High

250747

HNRPQ
Heterogeneous nuclear ribonucleoprotein Q

1

2

High-throughput

0.536

High

788729

SRP14
Signal recognition particle 14 kDa protein

1

1

High-throughput

0.536

High

1371367

FAF2
FAS-associated factor 2

1

1

High-throughput

0.536

High

1371368

ITCH
E3 ubiquitin-protein ligase Itchy homolog

1

17

High-throughput

0.536

High

1371376

BACD3
BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 3

1

9

High-throughput

0.536

High

1371377

CYBP
Calcyclin-binding protein

1

1

High-throughput

0.536

High

372760

MYC
Myc proto-oncogene protein

1

12

Small-scale

0.515

High

1096144

TADBP
TAR DNA-binding protein 43

1

8

High-throughput

0.515

High

326156

REC8
Meiotic recombination protein REC8 homolog

1

0

High-throughput

0.513

High

788127

ODO2
Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial

1

0

High-throughput

0.513

High

1347627

NPL4
Nuclear protein localization protein 4 homolog

1

0

High-throughput

0.513

High

1371379

DBLOH
Diablo IAP-binding mitochondrial protein

1

0

High-throughput

0.513

High

1371391

VATD
V-type proton ATPase subunit D

1

0

High-throughput

0.513

High

1371383

MYO15
Unconventional myosin-XV

1

5

High-throughput

0.494

High

1371366

EMID1
EMI domain-containing protein 1

1

2

High-throughput

0.489

High

1371390

KCTD3
BTB/POZ domain-containing protein KCTD3

1

11

High-throughput

0.489

High

1110925

LAPM5
Lysosomal-associated transmembrane protein 5

1

0

High-throughput

0.486

High

260264

BRD4
Bromodomain-containing protein 4

1

19

High-throughput

0.479

High

269117

MITF
Microphthalmia-associated transcription factor

1

2

Small-scale

0.479

High

350095

SNAI1
Zinc finger protein SNAI1

1

11

Small-scale

0.479

High

474874

VIME
Vimentin

1

6

Small-scale

0.479

High

481349

HMGB1
High mobility group protein B1

1

4

Small-scale

0.479

High

589331

RFA2
Replication protein A 32 kDa subunit

1

6

High-throughput

0.479

High

696127

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

6

High-throughput

0.479

High

761803

HSP74
Heat shock 70 kDa protein 4

1

8

Small-scale

0.479

High

768815

RFA3
Replication protein A 14 kDa subunit

1

7

High-throughput

0.479

High

790080

ZEB1
Zinc finger E-box-binding homeobox 1

1

5

Small-scale

0.479

High

838153

STAT1
Signal transducer and activator of transcription 1-alpha/beta

1

8

Small-scale

0.479

High

878529

PAXI
Paxillin

1

2

Small-scale

0.479

High

881266

FAS
Fatty acid synthase

1

3

Small-scale

0.479

High

910615

HNRPM
Heterogeneous nuclear ribonucleoprotein M

1

5

Small-scale

0.479

High

920864

ACLY
ATP-citrate synthase

1

1

Small-scale

0.479

High

928644

PMS1
PMS1 protein homolog 1

1

1

High-throughput

0.479

High

1004925

RNF4
E3 ubiquitin-protein ligase RNF4

1

2

High-throughput

0.479

High

1101869

SKP2
S-phase kinase-associated protein 2

1

5

Small-scale

0.479

High

1120271

HNRPD
Heterogeneous nuclear ribonucleoprotein D0

1

7

Small-scale

0.479

High

1254925

TRI67
Tripartite motif-containing protein 67

1

20

High-throughput

0.479

High

1287868

MTA70
N(6)-adenosine-methyltransferase catalytic subunit METTL3

1

1

Small-scale

0.479

High

1292854

STING
Stimulator of interferon genes protein

1

8

Small-scale

0.479

High

1358293

STAG1
Cohesin subunit SA-1

1

1

Small-scale

0.479

High

1361989

RFFL
E3 ubiquitin-protein ligase rififylin

1

11

Small-scale

0.479

High

1371369

NLRP3
NACHT, LRR and PYD domains-containing protein 3

1

4

Small-scale

0.479

High

1371385

FZR1
Fizzy-related protein homolog

1

9

Small-scale

0.479

High

1371392

ZHX2
Zinc fingers and homeoboxes protein 2

1

2

Small-scale

0.479

High

528317

THIO
Thioredoxin

1

0

Small-scale

0.458

High

717565

PDIA3
Protein disulfide-isomerase A3

1

0

High-throughput

0.458

High

1272413

GET4
Golgi to ER traffic protein 4 homolog

1

0

Small-scale

0.458

High

273912

CNOT3
CCR4-NOT transcription complex subunit 3

1

2

High-throughput

0.445

High

1371387

GAB2
GRB2-associated-binding protein 2

1

7

High-throughput

0.445

High

649790

SPR2D
Small proline-rich protein 2D

1

0

High-throughput

0.438

High

126326

TLR4
Toll-like receptor 4

1

1

Small-scale

0.437

High

718718

FCERG
High affinity immunoglobulin epsilon receptor subunit gamma

1

1

Small-scale

0.437

High

1064465

DSC1
Desmocollin-1

1

1

Small-scale

0.437

High

1155169

EREP1
Endosomal transmembrane epsin interactor 1

1

1

Small-scale

0.417

High

1100942

G3BP1
Ras GTPase-activating protein-binding protein 1

1

4

Small-scale

0.408

High

1245109

RHDF2
Inactive rhomboid protein 2

1

0

Small-scale

0.292

High

1371373

RM20
Large ribosomal subunit protein bL20m

1

0

High-throughput

0.282

High

1371389

TCAF1
TRPM8 channel-associated factor 1

1

0

High-throughput

0.279

Low

1371386

LORF1
LINE-1 retrotransposable element ORF1 protein

1

0

High-throughput

0.238

Low


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Last updated: 11Aug2025