HitPredict

Interactor 1: CBL (P22681)
E3 ubiquitin-protein ligase CBL (EC 2.3.2.27) (Casitas B-lineage lymphoma proto-oncogene) (Proto-oncogene c-Cbl) (RING finger protein 55) (RING-type E3 ubiquitin transferase CBL) (Signal transduction protein CBL)
Gene: CBL

Interactor 2: UBS3B (Q8TF42)
Ubiquitin-associated and SH3 domain-containing protein B (EC 3.1.3.48) (Cbl-interacting protein p70) (Suppressor of T-cell receptor signaling 1) (STS-1) (T-cell ubiquitin ligand 2) (TULA-2) (Tyrosine-protein phosphatase STS1/TULA2)
Gene: UBASH3B

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.84	0.80	0.823

Property	Details
Experiments	17675467, 15159412, 17880946, 16429130, 19380743
Identification Methods	affinity chromatography technology, pull down
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	UBA~UBA
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 906 Hs			1 649
+	Mm
		610620 CBL_MOUSE (1-906): 0: 888: 91.59		UBS3B_MOUSE (12-649): 0: 1037: 97.65
+	Hs
		610317 CBL_HUMAN (1-906): 0: 917: 100.00		UBS3A_HUMAN (12-643): 0: 947: 43.37
+	Mm
		610596 CBL_MOUSE (1-906): 0: 888: 91.59		UBS3A_MOUSE (12-643): 0: 953: 45.97
+	Hs
		883333 CBLB_HUMAN (23-901): 0: 793: 46.65		UBS3A_HUMAN (12-643): 0: 947: 43.37
+	Hs
		610338 CBL_HUMAN (1-906): 0: 917: 100.00		GRB2_HUMAN (156-319): 1.37e-45: 163: 21.56
+	Hs
		610437 CBL_HUMAN (1-906): 0: 917: 100.00		Q6ICN0_HUMAN (156-319): 1.29e-44: 160: 21.56
+	Mm
		610598 CBL_MOUSE (1-906): 0: 888: 91.59		GRB2_MOUSE (156-319): 3.38e-45: 161: 21.56
+	Hs
		47590 CBL_HUMAN (1-906): 0: 917: 100.00		A0A8V8TNS8_HUMAN (221-375): 3.23e-30: 125: 25.00
+	Hs
		610472 CBL_HUMAN (1-906): 0: 917: 100.00		SH3K1_HUMAN (221-375): 5.02e-29: 124: 25.00
+	Hs
		298949 CBL_HUMAN (1-906): 0: 917: 100.00		SRBS2_HUMAN (230-317): 1.4e-22: 105: 27.84
+	Hs
		235473 CBL_HUMAN (1-906): 0: 917: 100.00		VINEX_HUMAN (229-317): 1e-22: 104: 26.97
+	Hs
		610501 CBL_HUMAN (1-906): 0: 917: 100.00		SRBS1_HUMAN (258-317): 1.89e-18: 92.2: 40.00
+	Rn
		88774 D3ZV15_RAT (1-883): 0: 833: 89.00		GRB2_RAT (156-319): 1.37e-45: 163: 21.56
+	Mm
		610595 CBL_MOUSE (1-906): 0: 888: 91.59		SRBS2_MOUSE (230-317): 1.92e-22: 104: 27.84
+	Mm
		610630 CBL_MOUSE (1-906): 0: 888: 91.59		SH3K1_MOUSE (222-335): 2.37e-20: 97.6: 27.83
+	Mm
		610640 CBL_MOUSE (1-906): 0: 888: 91.59		GRAP_MOUSE (156-317): 5.29e-22: 96.8: 17.96
+	Mm
		610608 CBL_MOUSE (1-906): 0: 888: 91.59		SRBS1_MOUSE (258-317): 7.05e-19: 93.7: 40.00
+	Mm
		82735 B9EKI5_MOUSE (23-901): 0: 799: 47.22		GRB2_MOUSE (156-319): 3.38e-45: 161: 21.56
+	Hs
		298976 CBLB_HUMAN (23-901): 0: 793: 46.65		SRBS2_HUMAN (230-317): 1.4e-22: 105: 27.84
+	Hs
		235501 CBLB_HUMAN (23-901): 0: 793: 46.65		VINEX_HUMAN (229-317): 1e-22: 104: 26.97