HitPredict

Interactor 1: PTPRA (P18052)
Receptor-type tyrosine-protein phosphatase alpha (Protein-tyrosine phosphatase alpha) (R-PTP-alpha) (EC 3.1.3.48) (LCA-related phosphatase) (PTPTY-28)
Gene: PTPRA

Interactor 2: PTN5 (P54830)
Tyrosine-protein phosphatase non-receptor type 5 (EC 3.1.3.48) (Neural-specific protein-tyrosine phosphatase) (Striatum-enriched protein-tyrosine phosphatase) (STEP)
Gene: Ptpn5

Species: Mus musculus

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.55	1.00	0.747

Property	Details
Experiments	25951993
Identification Methods	affinity chromatography technology, pull down, enzymatic study
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	Y_phosphatase~Y_phosphatase
Common GO terms	GO:0004725 - protein tyrosine phosphatase activity
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 829 Mm			1 541
+	Rn
		766997 Q66HJ7_RAT (1-829): 0: 994: 92.55		PTN5_RAT (173-541): 0: 524: 98.65
+	Mm
		611443 PTPRA_MOUSE (1-829): 0: 1013: 100.00		PTPRA_MOUSE (270-532): 8.94e-108: 342: 32.96
+	Mm
		611454 PTPRA_MOUSE (1-829): 0: 1013: 100.00		PTPRD_MOUSE (272-532): 5.62e-102: 339: 35.45
+	Mm
		59106 PTPRA_MOUSE (1-829): 0: 1013: 100.00		PTPRF_MOUSE (279-532): 5.44e-98: 327: 35.63
+	Mm
		72835 PTPRA_MOUSE (1-829): 0: 1013: 100.00		PTPRS_MOUSE (275-532): 3.72e-97: 325: 36.23
+	Mm
		611448 PTPRA_MOUSE (1-829): 0: 1013: 100.00		PTPRE_MOUSE (253-532): 6.99e-97: 310: 31.51
+	Hs
		614646 PTPRA_HUMAN (1-829): 0: 981: 89.50		PTPRA_HUMAN (270-532): 4.64e-107: 340: 32.96
+	Hs
		614649 PTPRA_HUMAN (1-829): 0: 981: 89.50		PTPRE_HUMAN (275-532): 7.31e-97: 310: 32.59
+	Hs
		658822 PTPRS_HUMAN (5-826): 0: 894: 35.86		PTPRB_HUMAN (266-541): 1.35e-114: 375: 33.45
+	Mm
		611457 PTPRA_MOUSE (1-829): 0: 1013: 100.00		S4R1M0_MOUSE (265-529): 2.54e-71: 249: 25.17
+	Mm
		611444 PTPRA_MOUSE (1-829): 0: 1013: 100.00		PTPRM_MOUSE (227-534): 6.58e-67: 237: 25.00
+	Hs
		658845 PTPRD_HUMAN (14-826): 0: 894: 38.02		PTPRD_HUMAN (272-532): 5.51e-102: 339: 35.82
+	Hs
		658881 PTPRS_HUMAN (5-826): 0: 894: 35.86		PTPRD_HUMAN (272-532): 5.51e-102: 339: 35.82
+	Hs
		1102694 PTPRS_HUMAN (5-826): 0: 894: 35.86		PTPRS_HUMAN (275-532): 1.11e-100: 335: 35.85
+	Hs
		522657 PTPRS_HUMAN (5-826): 0: 894: 35.86		PTPRF_HUMAN (279-532): 1.22e-97: 326: 35.63
+	Mm
		883406 PTPRD_MOUSE (14-826): 0: 899: 38.14		PTPRE_MOUSE (253-532): 6.99e-97: 310: 31.51
+	Hs
		614650 PTPRA_HUMAN (1-829): 0: 981: 89.50		PTPRG_HUMAN (286-536): 1.97e-50: 188: 25.29