HitPredict

Interactor 1: CDK2 (P23573)
Cyclin-dependent kinase 2 (EC 2.7.11.22) (EC 2.7.11.23) (Cell division control protein 2 cognate)
Gene: CDK2

Interactor 2: CCNC (P25008)
Cyclin-C
Gene: CycC

Species: Drosophila melanogaster

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.43	1.00	0.656

Property	Details
Experiments	15575970
Identification Methods	two hybrid
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	Cyclin_C_2~Pkinase, Cyclin_N~Pkinase
Common GO terms	GO:0005634 - nucleus
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 314 Dm			1 267
+	Hs
		625350 CDK2_HUMAN (5-293): 1.16e-155: 438: 64.73		CCNA1_HUMAN (10-265): 6.46e-81: 252: 18.77
+	Hs
		538471 CDK2_HUMAN (5-293): 1.16e-155: 438: 64.73		CCNB1_HUMAN (1-266): 2.99e-79: 247: 15.19
+	Hs
		590125 CDK2_HUMAN (5-293): 1.16e-155: 438: 64.73		CCNA2_HUMAN (10-266): 1.76e-75: 237: 15.97
+	Hs
		303829 CDK2_HUMAN (5-293): 1.16e-155: 438: 64.73		CCNB2_HUMAN (1-266): 1.23e-73: 231: 15.93
+	Hs
		538521 CDK3_HUMAN (5-300): 3.85e-149: 422: 62.54		CCNB1_HUMAN (1-266): 2.99e-79: 247: 15.19
+	Mm
		956329 CDK2_MOUSE (5-293): 5.83e-147: 418: 55.00		CCNA1_MOUSE (10-265): 4.58e-80: 249: 18.39
+	Hs
		590162 CDK3_HUMAN (5-300): 3.85e-149: 422: 62.54		CCNA2_HUMAN (10-266): 1.76e-75: 237: 15.97
+	Mm
		851183 CDK2_MOUSE (5-293): 5.83e-147: 418: 55.00		CCNA2_MOUSE (7-266): 3.28e-77: 241: 15.79
+	Hs
		624422 CDK3_HUMAN (5-300): 3.85e-149: 422: 62.54		CCNC_HUMAN (1-258): 6.8e-73: 226: 71.71
+	Hs
		414711 CDK1_HUMAN (5-292): 7.45e-140: 398: 57.19		CCNB1_HUMAN (1-266): 2.99e-79: 247: 15.19
+	Mm
		956332 CDK2_MOUSE (5-293): 5.83e-147: 418: 55.00		CCNC_MOUSE (1-258): 2.29e-73: 227: 71.71
+	Dm
		540473 CDK2_DROME (1-314): 2.57e-144: 410: 100.00		CCNA_DROME (4-266): 6.05e-69: 222: 13.43
+	Hs
		625251 CDK2_HUMAN (5-293): 1.16e-155: 438: 64.73		CCNH_HUMAN (5-260): 3.88e-59: 192: 22.49
+	Hs
		303821 CDK1_HUMAN (5-292): 7.45e-140: 398: 57.19		CCNB2_HUMAN (1-266): 1.23e-73: 231: 15.93
+	Dm
		618463 CDK2_DROME (1-314): 2.57e-144: 410: 100.00		Q961D1_DROME (14-266): 5.73e-68: 217: 22.39
+	Hs
		236679 CDK1_HUMAN (5-292): 7.45e-140: 398: 57.19		CCNT1_HUMAN (9-243): 7.66e-67: 222: 20.49
+	Hs
		960107 CDK3_HUMAN (5-300): 3.85e-149: 422: 62.54		CCNQ_HUMAN (33-246): 1.06e-61: 196: 23.48
+	Hs
		851197 CDK3_HUMAN (5-300): 3.85e-149: 422: 62.54		CCNH_HUMAN (5-260): 3.88e-59: 192: 22.49
+	Dm
		184388 CDK2_DROME (1-314): 2.57e-144: 410: 100.00		O17144_DROME (10-260): 8.8e-43: 150: 22.81
+	Dm
		283943 CDK2_DROME (1-314): 2.57e-144: 410: 100.00		O76513_DROME (10-260): 8.78e-43: 150: 22.81