HitPredict

Interactor 1: EWS (Q01844)
RNA-binding protein EWS (EWS oncogene) (Ewing sarcoma breakpoint region 1 protein)
Gene: EWSR1

Interactor 2: CBP (Q92793)
CREB-binding protein (Histone lysine acetyltransferase CREBBP) (EC 2.3.1.48) (Protein lactyltransferas CREBBP) (EC 2.3.1.-) (Protein-lysine acetyltransferase CREBBP) (EC 2.3.1.-)
Gene: CREBBP

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.69	0.60	0.647

Property	Details
Experiments	24999758, 12459554, 32238831
Identification Methods	proximity labelling technology, pull down, two hybrid
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0006355 - regulation of DNA-templated transcription
Homologous interactions	12

Homologous interactions

Color coding for hit scores

	1 656 Hs			1 2442
+	Hs
		318689 EYA4_HUMAN (3-271): 6.07e-39: 154: 18.02		CBP_HUMAN (1-2442): 0: 1104: 100.00
+	Hs
		726964 FUS_HUMAN (55-545): 1.15e-31: 131: 30.35		CBP_HUMAN (1-2442): 0: 1104: 100.00
+	Hs
		998942 RBP56_HUMAN (109-555): 5.78e-53: 193: 35.05		EP300_HUMAN (1-2426): 0: 874: 55.06
+	Hs
		967131 EWS_HUMAN (1-656): 1.54e-47: 179: 100.00		EP300_HUMAN (1-2426): 0: 874: 55.06
+	Hs
		318610 EYA4_HUMAN (3-271): 6.07e-39: 154: 18.02		EP300_HUMAN (1-2426): 0: 874: 55.06
+	Hs
		726775 FUS_HUMAN (55-545): 1.15e-31: 131: 30.35		EP300_HUMAN (1-2426): 0: 874: 55.06
+	Hs
		1271215 RBP56_HUMAN (109-555): 5.78e-53: 193: 35.05		TRI33_HUMAN (694-1207): 3.25e-37: 156: 14.83
+	Hs
		967517 EWS_HUMAN (1-656): 1.54e-47: 179: 100.00		TRI33_HUMAN (694-1207): 3.25e-37: 156: 14.83
+	Hs
		518057 CO6A3_HUMAN (3-318): 2.21e-37: 152: 11.24		TRI33_HUMAN (694-1207): 3.25e-37: 156: 14.83
+	Hs
		967541 EWS_HUMAN (1-656): 1.54e-47: 179: 100.00		PCLO_HUMAN (1952-2441): 8.89e-13: 76.8: 9.55
+	Hs
		726907 FUS_HUMAN (55-545): 1.15e-31: 131: 30.35		PB1_HUMAN (1040-1275): 1.29e-12: 76: 14.83
+	Rn
		358576 CO1A1_RAT (2-511): 1.09e-19: 96.4: 14.92		CO1A2_RAT (2094-2441): 8.74e-11: 69.8: 11.11