HitPredict

Interactor 1: CCNE1 (P24864)
G1/S-specific cyclin-E1
Gene: CCNE1

Interactor 2: RBL1 (P28749)
Retinoblastoma-like protein 1 (107 kDa retinoblastoma-associated protein) (p107) (pRb1)
Gene: RBL1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	9891079
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0005654 - nucleoplasm
Homologous interactions	12

Homologous interactions

Color coding for hit scores

	1 410 Hs			1 1068
+	Hs
		590128 CCNA2_HUMAN (2-369): 1.62e-99: 304: 20.58		RBL1_HUMAN (1-1068): 0: 1528: 100.00
+	Hs
		660112 CCNA1_HUMAN (15-367): 4.41e-96: 297: 20.98		RBL1_HUMAN (1-1068): 0: 1528: 100.00
+	Hs
		624579 CCNE1_HUMAN (1-410): 2.36e-135: 395: 100.00		RBL2_HUMAN (19-1068): 0: 1356: 50.32
+	Hs
		590169 CCNA2_HUMAN (2-369): 1.62e-99: 304: 20.58		RBL2_HUMAN (19-1068): 0: 1356: 50.32
+	Hs
		331639 CCNE2_HUMAN (4-402): 7.36e-97: 297: 47.38		RBL2_HUMAN (19-1068): 0: 1356: 50.32
+	Hs
		943777 CCNA1_HUMAN (15-367): 4.41e-96: 297: 20.98		RBL2_HUMAN (19-1068): 0: 1356: 50.32
+	Hs
		538529 CCNB1_HUMAN (1-365): 5.55e-95: 293: 18.82		RBL2_HUMAN (19-1068): 0: 1356: 50.32
+	Hs
		414171 CCNE1_HUMAN (1-410): 2.36e-135: 395: 100.00		RB_HUMAN (735-1046): 2.21e-85: 298: 28.88
+	Hs
		414164 CCNA2_HUMAN (2-369): 1.62e-99: 304: 20.58		RB_HUMAN (735-1046): 2.21e-85: 298: 28.88
+	Hs
		414240 CCNA1_HUMAN (15-367): 4.41e-96: 297: 20.98		RB_HUMAN (735-1046): 2.21e-85: 298: 28.88
+	Hs
		414150 CCNB1_HUMAN (1-365): 5.55e-95: 293: 18.82		RB_HUMAN (735-1046): 2.21e-85: 298: 28.88
+	Dm
		872346 CCNE_DROME (47-402): 3.64e-91: 291: 38.79		RBF_DROME (779-1028): 7.56e-72: 258: 31.47