Protein: DUS22
Dual specificity protein phosphatase 22 (EC 3.1.3.16) (EC 3.1.3.48) (JNK pathway associated phosphatase) (JKAP) (JNK-stimulatory phosphatase-1) (JSP-1) (Low molecular weight dual specificity phosphatase 2) (LMW-DSP2) (Mitogen-activated protein kinase phosphatase x) (MAP kinase phosphatase x) (MKP-x)

Gene: DUS22, DUSP22
Organism: Homo sapiens
Interactions: 144
UniProt ID: Q9NRW4

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0002376 - immune system process
GO:0002710 - negative regulation of T cell mediated immunity
GO:0004722 - protein serine/threonine phosphatase activity
GO:0004725 - protein tyrosine phosphatase activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

63042

POTEF
POTE ankyrin domain family member F

2

14

High-throughput

0.811

High

659061

PTPRG
Receptor-type tyrosine-protein phosphatase gamma

2

1

High-throughput

0.811

High

1448933

KC1G3
Casein kinase I isoform gamma-3

1

2

High-throughput

0.691

High

374957

RASH
GTPase HRas

3

12

High-throughput

0.667

High

349323

GNA14
Guanine nucleotide-binding protein subunit alpha-14

2

14

High-throughput

0.628

High

893529

GNAQ
Guanine nucleotide-binding protein G(q) subunit alpha

2

15

High-throughput

0.628

High

920603

ARFP2
Arfaptin-2

2

1

High-throughput

0.628

High

1330635

CCYL1
Cyclin-Y-like protein 1

2

1

High-throughput

0.628

High

443535

CDK1
Cyclin-dependent kinase 1

1

4

High-throughput

0.618

High

1194628

DUS28
Dual specificity phosphatase 28

1

16

High-throughput

0.618

High

1429499

CLPB
Mitochondrial disaggregase

1

1

High-throughput

0.618

High

1448915

DUS22
Dual specificity protein phosphatase 22

1

16

High-throughput

0.618

High

982134

RAP1A
Ras-related protein Rap-1A

2

10

High-throughput

0.611

High

1128992

I5P1
Inositol polyphosphate-5-phosphatase A

2

0

High-throughput

0.602

High

1154760

VAMP3
Vesicle-associated membrane protein 3

2

0

High-throughput

0.602

High

1233513

LTOR1
Ragulator complex protein LAMTOR1

2

0

High-throughput

0.602

High

1446229

NRN1
Neuritin

2

0

High-throughput

0.602

High

1447769

DBLOH
Diablo IAP-binding mitochondrial protein

2

0

High-throughput

0.602

High

1448928

FBX7
F-box only protein 7

2

1

High-throughput

0.601

High

1340061

SVIP
Small VCP/p97-interacting protein

2

0

High-throughput

0.585

High

1138894

SYLM
Leucine--tRNA ligase, mitochondrial

2

2

High-throughput

0.574

High

1194650

KCD21
BTB/POZ domain-containing protein KCTD21

2

1

High-throughput

0.574

High

144324

ACACB
Acetyl-CoA carboxylase 2

1

3

High-throughput

0.536

High

252177

IF4E2
Eukaryotic translation initiation factor 4E type 2

1

1

High-throughput

0.536

High

463239

YES
Tyrosine-protein kinase Yes

1

12

High-throughput

0.536

High

482643

GNAO
Guanine nucleotide-binding protein G(o) subunit alpha

1

14

High-throughput

0.536

High

684514

CTNA2
Catenin alpha-2

1

3

High-throughput

0.536

High

692819

CALL3
Calmodulin-like protein 3

1

2

High-throughput

0.536

High

711195

PTN6
Tyrosine-protein phosphatase non-receptor type 6

1

5

High-throughput

0.536

High

716058

GNA11
Guanine nucleotide-binding protein subunit alpha-11

1

15

High-throughput

0.536

High

897555

BPL1
Biotin--protein ligase

1

1

High-throughput

0.536

High

956193

SRP54
Signal recognition particle subunit SRP54

1

2

High-throughput

0.536

High

992454

GBG5

1

1

High-throughput

0.536

High

1092665

ECH1
Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial

1

2

High-throughput

0.536

High

1125936

GNA13
Guanine nucleotide-binding protein subunit alpha-13

1

14

High-throughput

0.536

High

1229879

CYTSA
Cytospin-A

1

4

High-throughput

0.536

High

1336363

CCNY
Cyclin-Y

1

1

High-throughput

0.536

High

1420094

ULBP3
UL16-binding protein 3

1

1

High-throughput

0.536

High

1420104

ULBP2
UL16-binding protein 2

1

1

High-throughput

0.536

High

292477

PALM
Paralemmin-1

1

0

High-throughput

0.513

High

599631

STMN1
Stathmin

1

0

High-throughput

0.513

High

1271312

5MP2
eIF5-mimic protein 2

1

0

High-throughput

0.513

High

1357060

UBTD2
Ubiquitin domain-containing protein 2

1

0

High-throughput

0.513

High

1448917

PHAG1
Phosphoprotein associated with glycosphingolipid-enriched microdomains 1

1

0

High-throughput

0.513

High

1091844

TP4A2
Protein tyrosine phosphatase type IVA 2

1

5

Small-scale

0.501

High

885428

HXA1
Homeobox protein Hox-A1

1

2

High-throughput

0.494

High

388091

MBP
Myelin basic protein

1

0

High-throughput

0.493

High

1448916

CUED1
CUE domain-containing protein 1

1

1

High-throughput

0.489

High

130259

PGRC1
Membrane-associated progesterone receptor component 1

1

4

High-throughput

0.479

High

354409

TOM40
Mitochondrial import receptor subunit TOM40 homolog

1

1

High-throughput

0.479

High

375991

RASK
GTPase KRas

1

12

High-throughput

0.479

High

418750

GNAI2
Guanine nucleotide-binding protein G(i) subunit alpha-2

1

15

High-throughput

0.479

High

459922

APT
Adenine phosphoribosyltransferase

1

3

High-throughput

0.479

High

469339

ASNS
Asparagine synthetase [glutamine-hydrolyzing]

1

1

High-throughput

0.479

High

476046

GNAI3
Guanine nucleotide-binding protein G(i) subunit alpha-3

1

15

High-throughput

0.479

High

584811

NDKA
Nucleoside diphosphate kinase A

1

6

High-throughput

0.479

High

602272

TMM11
Transmembrane protein 11, mitochondrial

1

3

High-throughput

0.479

High

612315

ARF4
ADP-ribosylation factor 4

1

9

High-throughput

0.479

High

631501

RAB5A
Ras-related protein Rab-5A

1

8

High-throughput

0.479

High

720057

HMOX2
Heme oxygenase 2

1

1

High-throughput

0.479

High

777021

PPM1A
Protein phosphatase 1A

1

1

High-throughput

0.479

High

790952

TAGL2
Transgelin-2

1

5

High-throughput

0.479

High

827268

ARL1
ADP-ribosylation factor-like protein 1

1

10

High-throughput

0.479

High

853531

UBP5
Ubiquitin carboxyl-terminal hydrolase 5

1

6

High-throughput

0.479

High

857187

NSF
Vesicle-fusing ATPase

1

4

High-throughput

0.479

High

901064

RAB5C
Ras-related protein Rab-5C

1

8

High-throughput

0.479

High

902098

RAB9A
Ras-related protein Rab-9A

1

1

High-throughput

0.479

High

906461

DHB4
Peroxisomal multifunctional enzyme type 2

1

2

High-throughput

0.479

High

914066

SPSY
Spermine synthase

1

6

High-throughput

0.479

High

945167

CORO7
Coronin-7

1

7

High-throughput

0.479

High

956796

RAB10
Ras-related protein Rab-10

1

3

High-throughput

0.479

High

958033

RAB14
Ras-related protein Rab-14

1

2

High-throughput

0.479

High

989884

GNAI1
Guanine nucleotide-binding protein G(i) subunit alpha-1

1

15

High-throughput

0.479

High

1014968

ARF1
ADP-ribosylation factor 1

1

9

High-throughput

0.479

High

1015134

ARF5
ADP-ribosylation factor 5

1

9

High-throughput

0.479

High

1061306

RHG01
Rho GTPase-activating protein 1

1

1

High-throughput

0.479

High

1098763

NDK3
Nucleoside diphosphate kinase 3

1

6

High-throughput

0.479

High

1128293

MCM6
DNA replication licensing factor MCM6

1

7

High-throughput

0.479

High

1135473

GAPD1
GTPase-activating protein and VPS9 domain-containing protein 1

1

2

High-throughput

0.479

High

1243299

MEAK7
MTOR-associated protein MEAK7

1

1

High-throughput

0.479

High

1365772

GCN1
Stalled ribosome sensor GCN1

1

8

High-throughput

0.479

High

1395124

TMX3
Protein disulfide-isomerase TMX3

1

4

High-throughput

0.479

High

1400076

QKI
KH domain-containing RNA-binding protein QKI

1

3

High-throughput

0.479

High

1406239

CHP1
Calcineurin B homologous protein 1

1

2

High-throughput

0.479

High

1415387

DUS23
Dual specificity protein phosphatase 23

1

15

High-throughput

0.479

High

1432934

UN45A
Protein unc-45 homolog A

1

4

High-throughput

0.479

High

1448925

TMCO1
Calcium load-activated calcium channel

1

1

High-throughput

0.479

High

1448927

PTH2
Peptidyl-tRNA hydrolase 2, mitochondrial

1

3

High-throughput

0.479

High

124112

SNP23
Synaptosomal-associated protein 23

1

0

High-throughput

0.458

High

160919

STX16
Syntaxin-16

1

0

High-throughput

0.458

High

226375

SNG1
Synaptogyrin-1

1

0

High-throughput

0.458

High

245543

OPA1
Dynamin-like GTPase OPA1, mitochondrial

1

0

High-throughput

0.458

High

859087

RL27A
Large ribosomal subunit protein uL15

1

0

High-throughput

0.458

High

959268

ABCE1
ATP-binding cassette sub-family E member 1

1

0

High-throughput

0.458

High

1060300

MCL1
Induced myeloid leukemia cell differentiation protein Mcl-1

1

0

High-throughput

0.458

High

1358479

CANT1
Soluble calcium-activated nucleotidase 1

1

0

High-throughput

0.458

High

1403799

RMD3
Regulator of microtubule dynamics protein 3

1

0

High-throughput

0.458

High

1406928

NP1L4
Nucleosome assembly protein 1-like 4

1

0

High-throughput

0.458

High

1448920

ATX10
Ataxin-10

1

0

High-throughput

0.458

High

1448921

VTI1B
Vesicle transport through interaction with t-SNAREs homolog 1B

1

0

High-throughput

0.458

High

1448923

EI2BD
Translation initiation factor eIF2B subunit delta

1

0

High-throughput

0.458

High

1448924

MSPD1
Motile sperm domain-containing protein 1

1

0

High-throughput

0.458

High

1448926

RRP44
Exosome complex exonuclease RRP44

1

0

High-throughput

0.458

High

1448931

COPG1
Coatomer subunit gamma-1

1

0

High-throughput

0.458

High

518629

RAP2A
Ras-related protein Rap-2a

1

9

High-throughput

0.445

High

1243867

CTR9
RNA polymerase-associated protein CTR9 homolog

1

4

High-throughput

0.445

High

124512

HAX1
HCLS1-associated protein X-1

1

4

High-throughput

0.437

High

165662

SCAM3
Secretory carrier-associated membrane protein 3

1

1

High-throughput

0.437

High

181444

PGRC2
Membrane-associated progesterone receptor component 2

1

4

High-throughput

0.437

High

209116

CYB5B
Cytochrome b5 type B

1

2

High-throughput

0.437

High

257578

TI17B
Mitochondrial import inner membrane translocase subunit Tim17-B

1

5

High-throughput

0.437

High

257680

PRAF2
PRA1 family protein 2

1

3

High-throughput

0.437

High

469212

SRPRA
Signal recognition particle receptor subunit alpha

1

2

High-throughput

0.437

High

755801

MCM4
DNA replication licensing factor MCM4

1

7

High-throughput

0.437

High

1131407

GANAB
Neutral alpha-glucosidase AB

1

4

High-throughput

0.437

High

1357955

DCAKD
Dephospho-CoA kinase domain-containing protein

1

1

High-throughput

0.437

High

1403739

YMEL1
ATP-dependent zinc metalloprotease YME1L1

1

5

High-throughput

0.437

High

1405597

TI17A
Mitochondrial import inner membrane translocase subunit Tim17-A

1

5

High-throughput

0.437

High

1414098

TMM70
Transmembrane protein 70, mitochondrial

1

1

High-throughput

0.437

High

1414869

WDR18
WD repeat-containing protein 18

1

2

High-throughput

0.437

High

1415731

TMUB1
Transmembrane and ubiquitin-like domain-containing protein 1

1

1

High-throughput

0.437

High

1429132

MFF
Mitochondrial fission factor

1

1

High-throughput

0.437

High

1432753

TMX1
Thioredoxin-related transmembrane protein 1

1

6

High-throughput

0.437

High

1448919

MTCH1
Mitochondrial carrier homolog 1

1

6

High-throughput

0.437

High

1448932

MTCH2
Mitochondrial carrier homolog 2

1

6

High-throughput

0.437

High

1293507

COMD2
COMM domain-containing protein 2

1

0

High-throughput

0.426

High

1146645

TMED2
Transmembrane emp24 domain-containing protein 2

1

2

High-throughput

0.407

High

789674

HPCL1
Hippocalcin-like protein 1

2

0

High-throughput

0.328

High

1346852

OCC1
Overexpressed in colon carcinoma 1 protein

2

0

High-throughput

0.328

High

1081831

LTOR4
Ragulator complex protein LAMTOR4

1

0

High-throughput

0.279

Low

1243105

ERIC5
Glutamate-rich protein 5

1

0

High-throughput

0.279

Low

1258691

IKIP
Inhibitor of nuclear factor kappa-B kinase-interacting protein

1

0

High-throughput

0.279

Low

280350

SC22B
Vesicle-trafficking protein SEC22b

1

0

High-throughput

0.249

Low

1243244

PDXD1
Pyridoxal-dependent decarboxylase domain-containing protein 1

1

0

High-throughput

0.249

Low

1322727

F177A
Protein FAM177A1

1

0

High-throughput

0.249

Low

1381532

ERGI1
Endoplasmic reticulum-Golgi intermediate compartment protein 1

1

0

High-throughput

0.249

Low

1410678

APOL2
Apolipoprotein L2

1

0

High-throughput

0.249

Low

1448918

MIC19
MICOS complex subunit MIC19

1

0

High-throughput

0.249

Low

1448922

PCYOX
Prenylcysteine oxidase 1

1

0

High-throughput

0.249

Low

1448930

SAM50
Sorting and assembly machinery component 50 homolog

1

0

High-throughput

0.249

Low

1416214

FUND2
FUN14 domain-containing protein 2

1

0

High-throughput

0.232

Low

1416357

MND1
Meiotic nuclear division protein 1 homolog

1

0

High-throughput

0.232

Low

1448929

FA32A
Protein FAM32A

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025