Protein: SPEE
Spermidine synthase (SPDSY) (EC 2.5.1.16) (Putrescine aminopropyltransferase)

Gene: SPEE, SRM
Organism: Homo sapiens
Interactions: 54
UniProt ID: P19623

Gene Ontology (top 5):
GO:0004766 - spermidine synthase activity
GO:0005829 - cytosol
GO:0006595 - polyamine metabolic process
GO:0008295 - spermidine biosynthetic process
GO:0042802 - identical protein binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

624542

SPEE
Spermidine synthase

5

10

Small-scale

0.912

High

624547

CCNF
Cyclin-F

2

2

High-throughput

0.601

High

624549

TERF1
Telomeric repeat-binding factor 1

1

0

High-throughput

0.549

High

624550

CDC42
Cell division control protein 42 homolog

1

0

High-throughput

0.480

High

240720

PRKN
E3 ubiquitin-protein ligase parkin

1

1

High-throughput

0.479

High

411333

NTRK1
High affinity nerve growth factor receptor

1

2

High-throughput

0.479

High

624556

IKKE
Inhibitor of nuclear factor kappa-B kinase subunit epsilon

1

1

High-throughput

0.479

High

624557

DUS6
Dual specificity protein phosphatase 6

1

6

High-throughput

0.479

High

624569

CSN5
COP9 signalosome complex subunit 5

1

1

High-throughput

0.479

High

624572

CI072
Guanine nucleotide exchange factor C9orf72

1

1

High-throughput

0.479

High

624573

DUS9
Dual specificity protein phosphatase 9

1

5

High-throughput

0.479

High

624577

MLP3B
Microtubule-associated protein 1 light chain 3 beta

1

2

High-throughput

0.479

High

624581

ZRAN1
Ubiquitin thioesterase ZRANB1

1

1

High-throughput

0.479

High

624551

UBC12
NEDD8-conjugating enzyme Ubc12

1

0

High-throughput

0.458

High

624552

ABCE1
ATP-binding cassette sub-family E member 1

1

0

High-throughput

0.458

High

624553

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

0

High-throughput

0.458

High

624558

CRY2
Cryptochrome-2

1

0

High-throughput

0.458

High

624566

F184A
Protein FAM184A

1

0

High-throughput

0.458

High

624567

NHLC2
NHL repeat-containing protein 2

1

0

High-throughput

0.458

High

624570

DCPS
m7GpppX diphosphatase

1

0

High-throughput

0.458

High

624578

ATG5
Autophagy protein 5

1

0

High-throughput

0.458

High

624580

HDAC6
Protein deacetylase HDAC6

1

0

High-throughput

0.458

High

624583

FBX7
F-box only protein 7

1

0

High-throughput

0.458

High

624562

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

2

High-throughput

0.445

High

624563

A16L1
Autophagy-related protein 16-1

1

1

High-throughput

0.445

High

624560

MTUS2
Microtubule-associated tumor suppressor candidate 2

1

0

High-throughput

0.438

High

105305

APRIO
Alternative prion protein

1

1

High-throughput

0.437

High

259426

BRD4
Bromodomain-containing protein 4

1

3

High-throughput

0.437

High

352949

AGR2
Anterior gradient protein 2 homolog

1

1

High-throughput

0.437

High

371137

MYC
Myc proto-oncogene protein

1

2

High-throughput

0.437

High

587889

RFA2
Replication protein A 32 kDa subunit

1

1

High-throughput

0.437

High

624543

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

2

High-throughput

0.437

High

624544

DUS1
Dual specificity protein phosphatase 1

1

5

High-throughput

0.437

High

624545

RFA3
Replication protein A 14 kDa subunit

1

1

High-throughput

0.437

High

624555

DUS4
Dual specificity protein phosphatase 4

1

5

High-throughput

0.437

High

624559

DUS28
Dual specificity phosphatase 28

1

6

High-throughput

0.437

High

624565

TRI67
Tripartite motif-containing protein 67

1

2

High-throughput

0.437

High

624568

DUS19
Dual specificity protein phosphatase 19

1

6

High-throughput

0.437

High

624579

PKHA4
Pleckstrin homology domain-containing family A member 4

1

1

High-throughput

0.437

High

624571

OTUB1
Ubiquitin thioesterase OTUB1

1

0

High-throughput

0.426

High

624548

CEBPA
CCAAT/enhancer-binding protein alpha

1

2

High-throughput

0.408

High

619480

VCAM1
Vascular cell adhesion protein 1

2

0

High-throughput

0.313

High

187587

SOX12
Transcription factor SOX-12

1

0

High-throughput

0.282

High

624554

DMWD
Dystrophia myotonica WD repeat-containing protein

1

0

High-throughput

0.279

Low

624561

EFHC1
EF-hand domain-containing protein 1

1

0

High-throughput

0.279

Low

624574

DDA1
DET1- and DDB1-associated protein 1

1

0

High-throughput

0.279

Low

389015

FINC
Fibronectin

1

0

High-throughput

0.249

Low

565141

ITA4
Integrin alpha-4

1

0

High-throughput

0.249

Low

624546

BASI
Basigin

1

0

High-throughput

0.249

Low

624564

LMBRL
Protein LMBR1L

1

0

High-throughput

0.249

Low

624575

ACE2
Angiotensin-converting enzyme 2

1

0

High-throughput

0.249

Low

624576

ZDHC5
Palmitoyltransferase ZDHHC5

1

0

High-throughput

0.232

Low

624582

ITM2B
Integral membrane protein 2B

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025