Protein: SPSY
Spermine synthase (SPMSY) (EC 2.5.1.22) (Spermidine aminopropyltransferase)

Gene: SPSY, SMS
Organism: Homo sapiens
Interactions: 45
UniProt ID: P52788

Gene Ontology (top 5):
GO:0005829 - cytosol
GO:0006555 - methionine metabolic process
GO:0006595 - polyamine metabolic process
GO:0006597 - spermine biosynthetic process
GO:0016768 - spermine synthase activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

914044

SPSY
Spermine synthase

1

10

High-throughput

0.618

High

241164

PRKN
E3 ubiquitin-protein ligase parkin

2

1

High-throughput

0.584

High

637096

VATC1
V-type proton ATPase subunit C 1

1

0

High-throughput

0.513

High

914045

IGBP1
Immunoglobulin-binding protein 1

1

0

High-throughput

0.513

High

914046

XIAP
E3 ubiquitin-protein ligase XIAP

1

0

High-throughput

0.513

High

914050

STXB2
Syntaxin-binding protein 2

1

0

High-throughput

0.513

High

914058

IASPP
RelA-associated inhibitor

1

0

High-throughput

0.513

High

914061

CMBL
Carboxymethylenebutenolidase homolog

1

0

High-throughput

0.513

High

914062

PRPK
EKC/KEOPS complex subunit TP53RK

1

0

High-throughput

0.513

High

914065

OSGEP
tRNA N6-adenosine threonylcarbamoyltransferase

1

0

High-throughput

0.513

High

908082

KS6A3
Ribosomal protein S6 kinase alpha-3

1

0

High-throughput

0.486

High

914052

MAPK3
MAP kinase-activated protein kinase 3

1

0

High-throughput

0.486

High

914053

MK06
Mitogen-activated protein kinase 6

1

0

High-throughput

0.486

High

830393

CCNF
Cyclin-F

1

1

High-throughput

0.479

High

914059

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

1

High-throughput

0.479

High

914066

DUS22
Dual specificity protein phosphatase 22

1

6

High-throughput

0.479

High

914064

MNT
Max-binding protein MNT

1

1

High-throughput

0.470

High

624229

TFE3
Transcription factor E3

1

0

High-throughput

0.458

High

791203

SYUA
Alpha-synuclein

1

0

High-throughput

0.458

High

914069

TRM7
tRNA

1

0

High-throughput

0.458

High

107391

F8W6N3
Ubiquitin carboxyl-terminal hydrolase

1

1

High-throughput

0.445

High

914055

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

1

High-throughput

0.445

High

105619

APRIO
Alternative prion protein

1

1

High-throughput

0.437

High

259667

BRD4
Bromodomain-containing protein 4

1

1

High-throughput

0.437

High

353133

AGR2
Anterior gradient protein 2 homolog

1

1

High-throughput

0.437

High

411629

NTRK1
High affinity nerve growth factor receptor

1

1

High-throughput

0.437

High

588269

RFA2
Replication protein A 32 kDa subunit

1

1

High-throughput

0.437

High

606478

CEBPB
CCAAT/enhancer-binding protein beta

1

2

High-throughput

0.437

High

694995

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

1

High-throughput

0.437

High

767761

RFA3
Replication protein A 14 kDa subunit

1

1

High-throughput

0.437

High

914056

TRI67
Tripartite motif-containing protein 67

1

1

High-throughput

0.437

High

404739

PRIO
Major prion protein

1

0

High-throughput

0.426

High

914067

S22AB
Solute carrier family 22 member 11

1

0

High-throughput

0.426

High

886665

CEBPA
CCAAT/enhancer-binding protein alpha

1

2

High-throughput

0.373

High

568387

ETFA
Electron transfer flavoprotein subunit alpha, mitochondrial

1

0

High-throughput

0.279

Low

914049

LAGE3
EKC/KEOPS complex subunit LAGE3

1

0

High-throughput

0.279

Low

914054

PRC2B
Protein PRRC2B

1

0

High-throughput

0.279

Low

914057

HEAT3
HEAT repeat-containing protein 3

1

0

High-throughput

0.279

Low

914068

PDRG1
p53 and DNA damage-regulated protein 1

1

0

High-throughput

0.279

Low

914048

JIP2
C-Jun-amino-terminal kinase-interacting protein 2

1

0

High-throughput

0.265

Low

914047

TIF1B
Transcription intermediary factor 1-beta

1

0

High-throughput

0.249

Low

914060

SMCE1
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1

1

0

High-throughput

0.249

Low

914051

EZH2
Histone-lysine N-methyltransferase EZH2

1

0

High-throughput

0.238

Low

914063

IMP2L
Mitochondrial inner membrane protease subunit 2

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025