HitPredict

Interactor 1: CXCR2 (P25025)
C-X-C chemokine receptor type 2 (CXC-R2) (CXCR-2) (CDw128b) (GRO/MGSA receptor) (High affinity interleukin-8 receptor B) (IL-8R B) (IL-8 receptor type 2) (CD antigen CD182)
Gene: CXCR2

Interactor 2: CXCL5 (P42830)
C-X-C motif chemokine 5 (ENA-78(1-78)) (Epithelial-derived neutrophil-activating protein 78) (Neutrophil-activating peptide ENA-78) (Small-inducible cytokine B5) [Cleaved into: ENA-78(8-78); ENA-78(9-78)]
Gene: CXCL5

Species: Homo sapiens

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.60	1.00	0.776

Property	Details
Experiments	8702798, 9485196
Identification Methods	biochemical, competition binding
Interaction Type	physical association

Property	Details
Interacting Pfam domains	7tm_1~IL8
Common GO terms	GO:0006935 - chemotaxis GO:0006954 - inflammatory response GO:0007165 - signal transduction GO:0008284 - positive regulation of cell population proliferation GO:0030593 - neutrophil chemotaxis
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 360 Hs			1 114
+	Hs
		625758 CXCR2_HUMAN (1-360): 2.21e-83: 259: 100.00		CXCL6_HUMAN (1-114): 2.69e-34: 116: 79.83
+	Hs
		587767 CXCR2_HUMAN (1-360): 2.21e-83: 259: 100.00		CXCL2_HUMAN (38-112): 1.06e-27: 99.4: 46.67
+	Hs
		364042 CXCR2_HUMAN (1-360): 2.21e-83: 259: 100.00		CXCL7_HUMAN (43-114): 4.05e-27: 98.6: 50.00
+	Hs
		587786 CXCR2_HUMAN (1-360): 2.21e-83: 259: 100.00		CXCL3_HUMAN (43-112): 9.93e-27: 96.7: 51.43
+	Hs
		448988 CXCR2_HUMAN (1-360): 2.21e-83: 259: 100.00		GROA_HUMAN (43-112): 2.33e-26: 95.9: 50.00
+	Hs
		625736 CXCR1_HUMAN (18-349): 2.54e-69: 222: 78.92		CXCL5_HUMAN (1-114): 1.6e-39: 129: 100.00
+	Hs
		486185 CXCR2_HUMAN (1-360): 2.21e-83: 259: 100.00		IL8_HUMAN (44-113): 8.67e-24: 89: 36.62
+	Mm
		500672 CXCR2_MOUSE (1-348): 2e-78: 246: 70.69		CXCL2_MOUSE (38-112): 1.1e-28: 101: 49.33
+	Mm
		522397 CXCR2_MOUSE (1-348): 2e-78: 246: 70.69		GROA_MOUSE (39-109): 6.8e-28: 99.4: 53.52
+	Hs
		364080 CXCR3_HUMAN (21-357): 3.8e-79: 248: 40.71		PLF4_HUMAN (34-109): 4.27e-26: 95.1: 42.11
+	Hs
		849615 CCR3_HUMAN (50-358): 1.44e-79: 249: 33.65		CXCL9_HUMAN (39-105): 1.52e-20: 81.6: 39.71
+	Hs
		217751 CXCR3_HUMAN (21-357): 3.8e-79: 248: 40.71		CXL13_HUMAN (45-112): 4.22e-21: 82.4: 24.64
+	Hs
		150319 CCR3_HUMAN (50-358): 1.44e-79: 249: 33.65		CXL11_HUMAN (35-109): 1.33e-20: 80.9: 23.38
+	Hs
		830623 CXCR3_HUMAN (21-357): 3.8e-79: 248: 40.71		CXCL9_HUMAN (39-105): 1.52e-20: 81.6: 39.71
+	Hs
		364107 CCR3_HUMAN (50-358): 1.44e-79: 249: 33.65		CXL10_HUMAN (36-114): 3.23e-20: 80.1: 25.93
+	Hs
		150317 CXCR3_HUMAN (21-357): 3.8e-79: 248: 40.71		CXL11_HUMAN (35-109): 1.33e-20: 80.9: 23.38
+	Hs
		364105 CXCR3_HUMAN (21-357): 3.8e-79: 248: 40.71		CXL10_HUMAN (36-114): 3.23e-20: 80.1: 25.93
+	Hs
		364041 CXCR1_HUMAN (18-349): 2.54e-69: 222: 78.92		CXCL7_HUMAN (43-114): 4.05e-27: 98.6: 50.00
+	Hs
		448987 CXCR1_HUMAN (18-349): 2.54e-69: 222: 78.92		GROA_HUMAN (43-112): 2.33e-26: 95.9: 50.00
+	Hs
		486184 CXCR1_HUMAN (18-349): 2.54e-69: 222: 78.92		IL8_HUMAN (44-113): 8.67e-24: 89: 36.62