HitPredict

Interactor 1: APC (P25054)
Adenomatous polyposis coli protein (Protein APC) (Deleted in polyposis 2.5)
Gene: APC

Interactor 2: KC1E (P49674)
Casein kinase I isoform epsilon (CKI-epsilon) (CKIe) (EC 2.7.11.1)
Gene: CSNK1E

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.73	0.60	0.664

Property	Details
Experiments	29045831, 17218255, 11425858
Identification Methods	affinity chromatography technology, protein kinase assay, anti tag coimmunoprecipitation
Interaction Type	physical association, phosphorylation reaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 2843 Hs			1 416
+	Mm
		1206937 Q8BNP7_MOUSE (1-1058): 0: 1478: 95.09		KC1E_MOUSE (1-416): 8.22e-136: 397: 98.80
+	Hs
		626068 APC_HUMAN (1-2843): 0: 1316: 100.00		KC1A_HUMAN (2-326): 1.03e-134: 391: 69.54
+	Hs
		626069 APC_HUMAN (1-2843): 0: 1316: 100.00		KC1D_HUMAN (1-406): 2e-125: 370: 83.25
+	Hs
		92380 APC_HUMAN (1-2843): 0: 1316: 100.00		E9PC69_HUMAN (2-415): 6.43e-116: 358: 19.91
+	Hs
		257585 ANR17_HUMAN (1869-2843): 8.13e-62: 238: 14.08		KC1A_HUMAN (2-326): 1.03e-134: 391: 69.54
+	Hs
		1038954 NCOR2_HUMAN (821-2831): 1.68e-41: 171: 8.41		KCC2B_HUMAN (4-396): 1.37e-118: 361: 16.91
+	Hs
		682094 NCOR2_HUMAN (821-2831): 1.68e-41: 171: 8.41		AKT1_HUMAN (5-356): 7.92e-119: 356: 18.56
+	Hs
		943171 SRRM2_HUMAN (943-2827): 1.37e-30: 135: 8.96		KC1G2_HUMAN (3-348): 3.73e-119: 354: 50.28
+	Hs
		1186099 MICA3_HUMAN (1200-1800): 2.91e-09: 65.2: 13.62		AKT3_HUMAN (2-355): 3.23e-119: 357: 18.31