HitPredict

Interactor 1: APC (P25054)
Adenomatous polyposis coli protein (Protein APC) (Deleted in polyposis 2.5)
Gene: APC

Interactor 2: NAV1 (Q8NEY1)
Neuron navigator 1 (Pore membrane and/or filament-interacting-like protein 3) (Steerin-1) (Unc-53 homolog 1) (unc53H1)
Gene: NAV1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.48	0.60	0.541

Property	Details
Experiments	20936779
Identification Methods	two hybrid, two hybrid pooling approach
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm
Homologous interactions	12

Homologous interactions

Color coding for hit scores

	1 2843 Hs			1 1877
+	Hs
		626188 APC_HUMAN (1-2843): 0: 1316: 100.00		NAV3_HUMAN (57-1877): 3.46e-164: 558: 37.13
+	Hs
		626189 APC_HUMAN (1-2843): 0: 1316: 100.00		NAV2_HUMAN (57-1877): 2.29e-150: 518: 33.13
+	Hs
		626277 APC_HUMAN (1-2843): 0: 1316: 100.00		YM012_HUMAN (48-516): 3.2e-12: 73.4: 10.45
+	Hs
		554267 APC_HUMAN (1-2843): 0: 1316: 100.00		MUC1_HUMAN (261-990): 2.65e-10: 67.8: 11.52
+	Hs
		1303336 MUC4_HUMAN (710-2820): 1.56e-75: 284: 9.45		MUC4_HUMAN (599-1568): 8.65e-19: 96.2: 9.26
+	Hs
		1264771 TITIN_HUMAN (717-2430): 7.06e-29: 130: 7.55		TITIN_HUMAN (49-1203): 1.21e-11: 72.7: 9.26
+	Hs
		1056827 MDC1_HUMAN (1750-2784): 3.28e-21: 104: 11.74		MDC1_HUMAN (453-1439): 1.16e-17: 92.3: 10.02
+	Dm
		113976 M9PB30_DROME (1208-2013): 4.08e-21: 104: 9.83		M9PB30_DROME (29-556): 1e-12: 76.2: 7.39
+	Mm
		1351630 PCLO_MOUSE (810-2544): 4.79e-12: 74.5: 9.79		PCLO_MOUSE (31-1410): 9.38e-21: 102: 8.47
+	Hs
		1300934 CIC_HUMAN (722-2643): 2.1e-17: 92.4: 7.79		SP130_HUMAN (308-1214): 1.7e-13: 78.1: 8.71
+	Hs
		1056876 MICA3_HUMAN (1200-1800): 2.91e-09: 65.2: 13.62		MDC1_HUMAN (453-1439): 1.16e-17: 92.3: 10.02
+	Hs
		554259 MUC1_HUMAN (733-1434): 9.86e-12: 73.4: 9.40		MUC1_HUMAN (261-990): 2.65e-10: 67.8: 11.52