HitPredict

Interactor 1: BRD2 (P25440)
Bromodomain-containing protein 2 (O27.1.1)
Gene: BRD2

Interactor 2: H4 (P62805)
Histone H4
Gene: H4C1

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.93	0.60	0.747

Property	Details
Experiments	27248496, 30804502, 14731392, 31753913, 17148447, 19766566, 20709061
Identification Methods	affinity chromatography technology, fluorescent resonance energy transfer, unspecified method, pull down, x-ray crystallography, surface plasmon resonance
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0006334 - nucleosome assembly
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 801 Hs			1 103
+	Hs
		917299 BRD3_HUMAN (53-764): 4.91e-124: 390: 56.56		H4_HUMAN (1-103): 1.38e-48: 151: 100.00
+	Mm
		918262 BRDT_MOUSE (50-780): 1e-106: 351: 46.67		H4_MOUSE (1-103): 1.38e-48: 151: 100.00
+	Hs
		244235 BRD4_HUMAN (26-765): 9.66e-99: 336: 45.89		H4_HUMAN (1-103): 1.38e-48: 151: 100.00
+	Dm
		950405 Q9VCG6_DROME (37-479): 1.3e-61: 218: 22.81		H4_DROME (1-103): 4.51e-48: 150: 99.03
+	Hs
		917170 EP300_HUMAN (31-183): 5.52e-39: 159: 30.72		H4_HUMAN (1-103): 1.38e-48: 151: 100.00
+	Sc
		356614 RSC1_YEAST (75-483): 9.46e-42: 166: 17.03		H4_YEAST (18-103): 6.13e-41: 132: 90.70
+	Zm
		19319 A0A1D6HCG5_MAIZE (23-350): 4.07e-30: 129: 17.67		A0A1D6IAU4_MAIZE (1-103): 4.97e-53: 163: 98.06
+	Dm
		950390 Q4V5A7_DROME (58-211): 4.79e-33: 138: 31.17		H4_DROME (1-103): 4.51e-48: 150: 99.03
+	Sc
		356682 GCN5_YEAST (275-456): 2.99e-40: 155: 26.63		H4_YEAST (18-103): 6.13e-41: 132: 90.70
+	Hs
		917689 KAT2B_HUMAN (293-452): 1.59e-31: 134: 25.00		H4_HUMAN (1-103): 1.38e-48: 151: 100.00
+	Hs
		999008 EP300_HUMAN (31-183): 5.52e-39: 159: 30.72		H4G_HUMAN (1-98): 1.04e-38: 126: 84.69
+	Hs
		917688 KAT2A_HUMAN (293-452): 5.67e-30: 129: 24.38		H4_HUMAN (1-103): 1.38e-48: 151: 100.00
+	Hs
		917979 BRD7_HUMAN (25-338): 4.42e-29: 125: 17.13		H4_HUMAN (1-103): 1.38e-48: 151: 100.00
+	Dm
		532730 FSH_DROME (622-801): 2.57e-26: 118: 67.22		H4_DROME (1-103): 4.51e-48: 150: 99.03
+	Sp
		448927 YK82_SCHPO (27-186): 5.63e-31: 132: 29.88		H4_SCHPO (18-103): 4.87e-42: 135: 89.54
+	Sc
		356741 RSC2_YEAST (332-725): 2.08e-31: 133: 18.48		H4_YEAST (18-103): 6.13e-41: 132: 90.70
+	Sp
		448934 GCN5_SCHPO (289-454): 3.1e-31: 129: 22.29		H4_SCHPO (18-103): 4.87e-42: 135: 89.54
+	Hs
		917999 BAZ1A_HUMAN (49-197): 1.07e-22: 106: 21.94		H4_HUMAN (1-103): 1.38e-48: 151: 100.00
+	Hs
		1271442 KAT2A_HUMAN (293-452): 5.67e-30: 129: 24.38		H4G_HUMAN (1-98): 1.04e-38: 126: 84.69
+	Sc
		356752 BDF2_YEAST (352-546): 6.82e-22: 103: 22.22		H4_YEAST (18-103): 6.13e-41: 132: 90.70