HitPredict

Interactor 1: BRD2 (P25440)
Bromodomain-containing protein 2 (O27.1.1)
Gene: BRD2

Interactor 2: H2B2E (Q16778)
Histone H2B type 2-E (H2B-clustered histone 21) (Histone H2B-GL105) (Histone H2B.q) (H2B/q)
Gene: H2BC21

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.63	0.60	0.619

Property	Details
Experiments	35271311, 14731392
Identification Methods	affinity chromatography technology, unspecified method, fluorescent resonance energy transfer, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0006334 - nucleosome assembly
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 801 Hs			1 126
+	Hs
		631389 BRD2_HUMAN (1-773): 1.09e-171: 517: 100.00		H2B1C_HUMAN (1-126): 1.18e-53: 166: 99.21
+	Hs
		631358 BRD2_HUMAN (1-773): 1.09e-171: 517: 100.00		H2B1B_HUMAN (1-126): 1.74e-53: 165: 98.41
+	Hs
		1066994 BRD3_HUMAN (53-764): 4.91e-124: 390: 56.56		H2B2F_HUMAN (1-126): 2.34e-54: 168: 97.62
+	Hs
		918378 BRD3_HUMAN (53-764): 4.91e-124: 390: 56.56		H2B1C_HUMAN (1-126): 1.18e-53: 166: 99.21
+	Hs
		707639 BRD3_HUMAN (53-764): 4.91e-124: 390: 56.56		H2B1B_HUMAN (1-126): 1.74e-53: 165: 98.41
+	Hs
		243805 BRD4_HUMAN (26-765): 9.66e-99: 336: 45.89		H2B1J_HUMAN (1-126): 7.8e-54: 166: 99.21
+	Hs
		244236 BRD4_HUMAN (26-765): 9.66e-99: 336: 45.89		H2B1C_HUMAN (1-126): 1.18e-53: 166: 99.21
+	Hs
		244513 BRD4_HUMAN (26-765): 9.66e-99: 336: 45.89		H2B2E_HUMAN (1-126): 6.69e-54: 166: 100.00
+	Hs
		244752 BRD4_HUMAN (26-765): 9.66e-99: 336: 45.89		H2B1H_HUMAN (1-126): 6.27e-54: 166: 98.41
+	Hs
		241395 BRD4_HUMAN (26-765): 9.66e-99: 336: 45.89		H2B1K_HUMAN (1-126): 1.56e-53: 165: 98.41
+	Hs
		244011 BRD4_HUMAN (26-765): 9.66e-99: 336: 45.89		H2B1B_HUMAN (1-126): 1.74e-53: 165: 98.41
+	Hs
		244660 BRD4_HUMAN (26-765): 9.66e-99: 336: 45.89		H2B3B_HUMAN (1-126): 1.01e-51: 161: 96.03
+	Hs
		998782 EP300_HUMAN (31-183): 5.52e-39: 159: 30.72		H2B2E_HUMAN (1-126): 6.69e-54: 166: 100.00
+	Hs
		707606 EP300_HUMAN (31-183): 5.52e-39: 159: 30.72		H2B1B_HUMAN (1-126): 1.74e-53: 165: 98.41
+	Hs
		707702 KAT2B_HUMAN (293-452): 1.59e-31: 134: 25.00		H2B1B_HUMAN (1-126): 1.74e-53: 165: 98.41
+	Sc
		355953 RSC1_YEAST (75-483): 9.46e-42: 166: 17.03		H2B2_YEAST (3-125): 4.73e-37: 124: 71.55
+	Sc
		355564 RSC1_YEAST (75-483): 9.46e-42: 166: 17.03		H2B1_YEAST (3-125): 1.81e-36: 122: 71.55
+	Sc
		355988 GCN5_YEAST (275-456): 2.99e-40: 155: 26.63		H2B2_YEAST (3-125): 4.73e-37: 124: 71.55
+	At
		1308008 GCN5_ARATH (351-449): 7.8e-33: 136: 37.62		H2B10_ARATH (3-125): 1.12e-43: 141: 59.71
+	Sc
		355611 GCN5_YEAST (275-456): 2.99e-40: 155: 26.63		H2B1_YEAST (3-125): 1.81e-36: 122: 71.55