HitPredict

Interactor 1: PSB1 (P20618)
Proteasome subunit beta type-1 (Macropain subunit C5) (Multicatalytic endopeptidase complex subunit C5) (Proteasome component C5) (Proteasome gamma chain) (Proteasome subunit beta-6) (beta-6)
Gene: PSMB1

Interactor 2: PSMF1 (Q92530)
Proteasome inhibitor PI31 subunit (hPI31)
Gene: PSMF1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.75	1.00	0.871

Property	Details
Experiments	33961781, 35271311, 28514442
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	PI31_Prot_C~Proteasome
Common GO terms	GO:0005829 - cytosol GO:0005839 - proteasome core complex GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 241 Hs			1 271
+	Hs
		887573 PSB3_HUMAN (31-241): 3.47e-82: 246: 23.94		PSMF1_HUMAN (1-271): 3.21e-157: 439: 100.00
+	Hs
		165385 PSA7_HUMAN (17-241): 1.12e-76: 233: 13.54		PSMF1_HUMAN (1-271): 3.21e-157: 439: 100.00
+	Hs
		954868 PSA6_HUMAN (17-240): 8.73e-77: 233: 14.91		PSMF1_HUMAN (1-271): 3.21e-157: 439: 100.00
+	Hs
		681692 PSA4_HUMAN (8-240): 3.47e-75: 230: 17.72		PSMF1_HUMAN (1-271): 3.21e-157: 439: 100.00
+	Hs
		700697 PSA5_HUMAN (16-240): 2.3e-74: 227: 16.67		PSMF1_HUMAN (1-271): 3.21e-157: 439: 100.00
+	Hs
		954826 PSA6_HUMAN (17-240): 8.73e-77: 233: 14.91		Q5QPM9_HUMAN (1-183): 1.98e-104: 302: 100.00
+	Dm
		1466215 PSA6_DROME (19-240): 3e-66: 207: 15.04		PSMF1_DROME (3-270): 5.02e-108: 315: 29.46
+	Hs
		887706 PSB2_HUMAN (40-233): 2.79e-09: 57: 24.62		PSMF1_HUMAN (1-271): 3.21e-157: 439: 100.00