Protein: PSB2
Proteasome subunit beta type-2 (Macropain subunit C7-I) (Multicatalytic endopeptidase complex subunit C7-I) (Proteasome component C7-I) (Proteasome subunit beta-4) (beta-4)

Gene: PSB2, PSMB2
Organism: Homo sapiens
Interactions: 203
UniProt ID: P49721

Gene Ontology (top 5):
GO:0000502 - proteasome complex
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005737 - cytoplasm
GO:0005829 - cytosol

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

681125

PSA2
Proteasome subunit alpha type-2

8

20

Small-scale

0.972

High

680814

PSA1
Proteasome subunit alpha type-1

9

20

Small-scale

0.970

High

887495

PSB3
Proteasome subunit beta type-3

7

20

Small-scale

0.967

High

165289

PSA7
Proteasome subunit alpha type-7

8

20

Small-scale

0.965

High

887713

PSB7
Proteasome subunit beta type-7

7

20

Small-scale

0.954

High

887743

POMP
Proteasome maturation protein

5

15

Small-scale

0.932

High

633629

PSB1
Proteasome subunit beta type-1

5

20

Small-scale

0.930

High

887644

PSME1
Proteasome activator complex subunit 1

5

20

Small-scale

0.925

High

700581

PSA5
Proteasome subunit alpha type-5

5

20

Small-scale

0.922

High

887632

PSA6
Proteasome subunit alpha type-6

5

20

Small-scale

0.922

High

701114

PSB5
Proteasome subunit beta type-5

5

19

Small-scale

0.919

High

681596

PSA4
Proteasome subunit alpha type-4

5

20

Small-scale

0.919

High

700850

PSB4
Proteasome subunit beta type-4

5

19

Small-scale

0.919

High

700998

PSB6
Proteasome subunit beta type-6

5

19

Small-scale

0.919

High

700503

PSB9
Proteasome subunit beta type-9

4

20

High-throughput

0.903

High

127904

PSD11
26S proteasome non-ATPase regulatory subunit 11

4

20

Small-scale

0.900

High

887655

PSME4
Proteasome activator complex subunit 4

4

12

Small-scale

0.900

High

887737

PSME2
Proteasome activator complex subunit 2

4

20

Small-scale

0.892

High

337458

PSMG1
Proteasome assembly chaperone 1

3

5

High-throughput

0.871

High

681297

PSA3
Proteasome subunit alpha type-3

3

20

Small-scale

0.855

High

778632

PRS7
26S proteasome regulatory subunit 7

3

20

Small-scale

0.839

High

887706

PSMF1
Proteasome inhibitor PI31 subunit

2

4

High-throughput

0.811

High

128180

PSD12
26S proteasome non-ATPase regulatory subunit 12

2

20

Small-scale

0.776

High

851268

PRS6B
26S proteasome regulatory subunit 6B

2

20

Small-scale

0.776

High

887635

PRS4
26S proteasome regulatory subunit 4

2

20

Small-scale

0.776

High

887636

PRS8
26S proteasome regulatory subunit 8

2

20

Small-scale

0.776

High

887638

PRS10
26S proteasome regulatory subunit 10B

2

20

Small-scale

0.776

High

887620

PSB2
Proteasome subunit beta type-2

2

20

Small-scale

0.755

High

610266

PRS6A
26S proteasome regulatory subunit 6A

2

20

Small-scale

0.737

High

138018

PSDE
26S proteasome non-ATPase regulatory subunit 14

5

20

Small-scale

0.699

High

887746

FBX7
F-box only protein 7

4

7

Small-scale

0.694

High

887697

PSMA8
Proteasome subunit alpha-type 8

1

20

High-throughput

0.691

High

887750

UCHL5
Ubiquitin carboxyl-terminal hydrolase isozyme L5

4

20

Small-scale

0.691

High

887643

UBE3A
Ubiquitin-protein ligase E3A

4

20

Small-scale

0.676

High

887668

AKIR2
Akirin-2

3

8

Small-scale

0.667

High

887629

PSMD4
26S proteasome non-ATPase regulatory subunit 4

3

14

Small-scale

0.650

High

887647

PSMD2
26S proteasome non-ATPase regulatory subunit 2

3

20

Small-scale

0.643

High

887714

PSMD1
26S proteasome non-ATPase regulatory subunit 1

3

20

Small-scale

0.633

High

887707

PSMG2
Proteasome assembly chaperone 2

2

11

High-throughput

0.628

High

843381

HD
Huntingtin

2

5

High-throughput

0.621

High

887703

UBCP1
Ubiquitin-like domain-containing CTD phosphatase 1

2

9

Small-scale

0.611

High

887736

AMFR
E3 ubiquitin-protein ligase AMFR

2

16

High-throughput

0.611

High

887645

INCA1
Protein INCA1

2

1

High-throughput

0.606

High

887665

KR197
Keratin-associated protein 19-7

2

1

High-throughput

0.606

High

887688

KR191
Keratin-associated protein 19-1

2

1

High-throughput

0.606

High

887744

AXIN2
Axin-2

2

1

High-throughput

0.606

High

619612

VCAM1
Vascular cell adhesion protein 1

2

3

High-throughput

0.601

High

887639

RS27A
Ubiquitin-ribosomal protein eS31 fusion protein

2

20

Small-scale

0.601

High

887656

PSMD6
26S proteasome non-ATPase regulatory subunit 6

2

20

Small-scale

0.601

High

887741

PSD13
26S proteasome non-ATPase regulatory subunit 13

2

14

Small-scale

0.601

High

241085

PRKN
E3 ubiquitin-protein ligase parkin

2

20

Small-scale

0.584

High

507683

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

2

20

Small-scale

0.584

High

536750

HSP7C
Heat shock cognate 71 kDa protein

2

8

Small-scale

0.584

High

830342

CCNF
Cyclin-F

2

5

High-throughput

0.584

High

887626

UBP14
Ubiquitin carboxyl-terminal hydrolase 14

2

12

Small-scale

0.584

High

887627

RD23A
UV excision repair protein RAD23 homolog A

2

20

Small-scale

0.584

High

887628

RD23B
UV excision repair protein RAD23 homolog B

2

20

Small-scale

0.584

High

887650

CUL3
Cullin-3

2

5

High-throughput

0.584

High

887675

ECM29
Proteasome adapter and scaffold protein ECM29

2

15

Small-scale

0.584

High

887735

UBQL2
Ubiquilin-2

2

20

Small-scale

0.584

High

887663

KR196
Keratin-associated protein 19-6

2

0

High-throughput

0.580

High

887664

KR195
Keratin-associated protein 19-5

2

0

High-throughput

0.580

High

114591

H0YKT8
Proteasome subunit beta

1

20

High-throughput

0.575

High

887630

TERA
Transitional endoplasmic reticulum ATPase

1

13

High-throughput

0.575

High

887634

PSME3
Proteasome activator complex subunit 3

1

20

Small-scale

0.575

High

215270

TXNL1
Thioredoxin-like protein 1

2

5

Small-scale

0.571

High

395697

ESR1
Estrogen receptor

2

6

High-throughput

0.571

High

887661

ADRM1
Proteasomal ubiquitin receptor ADRM1

2

10

Small-scale

0.571

High

887671

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

2

6

High-throughput

0.571

High

529343

TAU
Microtubule-associated protein tau

2

7

High-throughput

0.552

High

415428

HSPB1
Heat shock protein beta-1

1

2

High-throughput

0.541

High

613673

GPX2
Glutathione peroxidase 2

1

3

High-throughput

0.541

High

210891

PSMD3
26S proteasome non-ATPase regulatory subunit 3

1

10

High-throughput

0.536

High

389157

FINC
Fibronectin

1

3

High-throughput

0.536

High

563421

CFTR
Cystic fibrosis transmembrane conductance regulator

1

8

High-throughput

0.536

High

887622

PSN1
Presenilin-1

1

4

High-throughput

0.536

High

887641

SKP1
S-phase kinase-associated protein 1

1

9

High-throughput

0.536

High

887658

IQCB1
IQ calmodulin-binding motif-containing protein 1

1

14

High-throughput

0.536

High

887659

UBE3C
Ubiquitin-protein ligase E3C

1

20

High-throughput

0.536

High

887685

SYVN1
E3 ubiquitin-protein ligase synoviolin

1

20

High-throughput

0.536

High

887690

CDK20
Cyclin-dependent kinase 20

1

5

High-throughput

0.536

High

887695

ARRD4
Arrestin domain-containing protein 4

1

8

High-throughput

0.536

High

887716

SLX1
Structure-specific endonuclease subunit SLX1

1

4

High-throughput

0.536

High

887728

ANKZ1
tRNA endonuclease ANKZF1

1

1

High-throughput

0.536

High

887747

LMBL1
Lethal(3)malignant brain tumor-like protein 1

1

6

High-throughput

0.536

High

887682

KCTD9
BTB/POZ domain-containing protein KCTD9

1

1

High-throughput

0.523

High

887751

DDX49
Probable ATP-dependent RNA helicase DDX49

1

0

High-throughput

0.518

High

97069

E9PMD8
Proteasome 26S subunit, ATPase 3

1

20

High-throughput

0.514

High

181980

UBD
Ubiquitin D

1

20

Small-scale

0.501

High

339688

KLF8
Krueppel-like factor 8

1

20

High-throughput

0.500

High

887651

KLF5
Krueppel-like factor 5

1

20

High-throughput

0.500

High

887718

KLF16
Krueppel-like factor 16

1

20

High-throughput

0.500

High

539665

MBL2
Mannose-binding protein C

1

3

High-throughput

0.489

High

566251

K1C13
Keratin, type I cytoskeletal 13

1

6

High-throughput

0.481

High

185525

OGT1
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit

1

5

Small-scale

0.479

High

223990

GET3
ATPase GET3

1

3

Small-scale

0.479

High

226728

SGTA
Small glutamine-rich tetratricopeptide repeat-containing protein alpha

1

7

Small-scale

0.479

High

259625

BRD4
Bromodomain-containing protein 4

1

7

High-throughput

0.479

High

271985

OBSL1
Obscurin-like protein 1

1

9

High-throughput

0.479

High

293376

CD123
Translation initiation factor eIF2 assembly protein

1

6

High-throughput

0.479

High

315284

RECQ4
ATP-dependent DNA helicase Q4

1

10

High-throughput

0.479

High

319526

UFL1
E3 UFM1-protein ligase 1

1

2

High-throughput

0.479

High

325729

UBR5
E3 ubiquitin-protein ligase UBR5

1

20

Small-scale

0.479

High

371472

MYC
Myc proto-oncogene protein

1

5

High-throughput

0.479

High

375292

RASK
GTPase KRas

1

1

High-throughput

0.479

High

425376

ISG15
Ubiquitin-like protein ISG15

1

20

Small-scale

0.479

High

519842

ANDR
Androgen receptor

1

6

High-throughput

0.479

High

543097

UBL4A
Ubiquitin-like protein 4A

1

20

Small-scale

0.479

High

565233

ITA4
Integrin alpha-4

1

2

High-throughput

0.479

High

588196

RFA2
Replication protein A 32 kDa subunit

1

4

High-throughput

0.479

High

600769

HSP76
Heat shock 70 kDa protein 6

1

10

Small-scale

0.479

High

607550

PTN2
Tyrosine-protein phosphatase non-receptor type 2

1

7

High-throughput

0.479

High

694919

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

6

High-throughput

0.479

High

767689

RFA3
Replication protein A 14 kDa subunit

1

4

High-throughput

0.479

High

854796

RECQ1
ATP-dependent DNA helicase Q1

1

9

High-throughput

0.479

High

856588

BAG6
Large proline-rich protein BAG6

1

20

Small-scale

0.479

High

861064

MAP1B
Microtubule-associated protein 1B

1

8

High-throughput

0.479

High

887621

MCM2
DNA replication licensing factor MCM2

1

3

High-throughput

0.479

High

887624

PLK1
Serine/threonine-protein kinase PLK1

1

16

High-throughput

0.479

High

887625

ATX3
Ataxin-3

1

4

High-throughput

0.479

High

887633

UBC12
NEDD8-conjugating enzyme Ubc12

1

11

High-throughput

0.479

High

887637

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

11

High-throughput

0.479

High

887642

PO5F1
POU domain, class 5, transcription factor 1

1

3

High-throughput

0.479

High

887646

NFX1
Transcriptional repressor NF-X1

1

8

High-throughput

0.479

High

887648

BIRC3
Baculoviral IAP repeat-containing protein 3

1

6

High-throughput

0.479

High

887649

SQSTM
Sequestosome-1

1

5

Small-scale

0.479

High

887653

FKBP8
Peptidyl-prolyl cis-trans isomerase FKBP8

1

14

Small-scale

0.479

High

887657

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

2

High-throughput

0.479

High

887662

MK06
Mitogen-activated protein kinase 6

1

3

High-throughput

0.479

High

887666

LARP7
La-related protein 7

1

6

High-throughput

0.479

High

887667

MIDN
Midnolin

1

6

High-throughput

0.479

High

887672

UBR4
E3 ubiquitin-protein ligase UBR4

1

1

Small-scale

0.479

High

887673

DDI2
Protein DDI1 homolog 2

1

20

High-throughput

0.479

High

887676

VIR
Protein virilizer homolog

1

6

High-throughput

0.479

High

887678

PRP8
Pre-mRNA-processing-splicing factor 8

1

2

High-throughput

0.479

High

887681

TRI67
Tripartite motif-containing protein 67

1

19

High-throughput

0.479

High

887683

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

1

High-throughput

0.479

High

887684

HUWE1
E3 ubiquitin-protein ligase HUWE1

1

10

High-throughput

0.479

High

887686

CAND1
Cullin-associated NEDD8-dissociated protein 1

1

4

Small-scale

0.479

High

887687

GOLI
E3 ubiquitin-protein ligase RNF130

1

20

High-throughput

0.479

High

887696

TNIP2
TNFAIP3-interacting protein 2

1

2

High-throughput

0.479

High

887700

RBCC1
RB1-inducible coiled-coil protein 1

1

3

High-throughput

0.479

High

887702

RN138
E3 ubiquitin-protein ligase RNF138

1

7

Small-scale

0.479

High

887704

ASB11
Ankyrin repeat and SOCS box protein 11

1

3

High-throughput

0.479

High

887705

SSH1
Protein phosphatase Slingshot homolog 1

1

3

High-throughput

0.479

High

887708

CHM4C
Charged multivesicular body protein 4c

1

4

High-throughput

0.479

High

887710

RITA1
RBPJ-interacting and tubulin-associated protein 1

1

6

Small-scale

0.479

High

887711

CI072
Guanine nucleotide exchange factor C9orf72

1

6

High-throughput

0.479

High

887712

CIC
Protein capicua homolog

1

2

High-throughput

0.479

High

887715

DNJC7
DnaJ homolog subfamily C member 7

1

5

High-throughput

0.479

High

887717

RN126
E3 ubiquitin-protein ligase RNF126

1

7

Small-scale

0.479

High

887720

AMRA1
Activating molecule in BECN1-regulated autophagy protein 1

1

6

Small-scale

0.479

High

887721

UBE2O
(E3-independent) E2 ubiquitin-conjugating enzyme

1

12

High-throughput

0.479

High

887722

PIP30
PSME3-interacting protein

1

2

Small-scale

0.479

High

887723

SHRPN
Sharpin

1

1

Small-scale

0.479

High

887726

EGLN3
Prolyl hydroxylase EGLN3

1

2

High-throughput

0.479

High

887727

RMD5A
E3 ubiquitin-protein transferase RMND5A

1

2

High-throughput

0.479

High

887729

CYLD
Ubiquitin carboxyl-terminal hydrolase CYLD

1

4

High-throughput

0.479

High

887730

BIRC6
Dual E2 ubiquitin-conjugating enzyme/E3 ubiquitin-protein ligase BIRC6

1

14

Small-scale

0.479

High

887732

RN181
E3 ubiquitin-protein ligase RNF181

1

8

Small-scale

0.479

High

887733

HDAC6
Protein deacetylase HDAC6

1

4

Small-scale

0.479

High

887734

ZRAN1
Ubiquitin thioesterase ZRANB1

1

7

High-throughput

0.479

High

887738

FZR1
Fizzy-related protein homolog

1

11

High-throughput

0.479

High

887739

UBQL1
Ubiquilin-1

1

20

High-throughput

0.479

High

887740

CHIP
E3 ubiquitin-protein ligase CHIP

1

5

Small-scale

0.479

High

887742

NSF1C
NSFL1 cofactor p47

1

1

Small-scale

0.479

High

887748

UBP15
Ubiquitin carboxyl-terminal hydrolase 15

1

7

Small-scale

0.479

High

887749

TRAF6
TNF receptor-associated factor 6

1

10

High-throughput

0.479

High

49889

A1A4E9
Keratin 13

1

6

High-throughput

0.470

High

643226

MUTA
Methylmalonyl-CoA mutase, mitochondrial

1

0

High-throughput

0.458

High

887660

ELAV1
ELAV-like protein 1

1

0

Small-scale

0.458

High

887680

BAKOR
Beclin 1-associated autophagy-related key regulator

1

0

High-throughput

0.458

High

887689

TEX2
Testis-expressed protein 2

1

0

High-throughput

0.458

High

887699

SPP
Signal peptide peptidase

1

0

Small-scale

0.458

High

516158

HS71A
Heat shock 70 kDa protein 1A

1

10

Small-scale

0.445

High

516190

HS71B
Heat shock 70 kDa protein 1B

1

10

Small-scale

0.445

High

874128

PSMD8
26S proteasome non-ATPase regulatory subunit 8

1

8

Small-scale

0.445

High

887623

PSMD7
26S proteasome non-ATPase regulatory subunit 7

1

20

Small-scale

0.445

High

887631

RIPK4
Receptor-interacting serine/threonine-protein kinase 4

1

2

High-throughput

0.445

High

887640

RL40
Ubiquitin-ribosomal protein eL40 fusion protein

1

18

Small-scale

0.445

High

887652

DAG1
Dystroglycan 1

1

1

Small-scale

0.445

High

887669

TMM31
Transmembrane protein 31

1

7

High-throughput

0.445

High

887674

Q5VWC4
26S proteasome non-ATPase regulatory subunit 4

1

14

High-throughput

0.445

High

887694

CTL5
Choline transporter-like protein 5

1

10

High-throughput

0.445

High

887724

GBRL1
Gamma-aminobutyric acid receptor-associated protein-like 1

1

6

High-throughput

0.445

High

887731

SPHK1
Sphingosine kinase 1

1

1

Small-scale

0.445

High

353107

AGR2
Anterior gradient protein 2 homolog

1

5

High-throughput

0.437

High

887654

GRM2
Metabotropic glutamate receptor 2

1

6

High-throughput

0.437

High

887670

RNFT1
E3 ubiquitin-protein ligase RNFT1

1

20

High-throughput

0.437

High

887677

BLT3A
Bridge-like lipid transfer protein family member 3A

1

1

High-throughput

0.437

High

887679

LMBRL
Protein LMBR1L

1

2

High-throughput

0.437

High

887691

PLD6
Mitochondrial cardiolipin hydrolase

1

1

High-throughput

0.437

High

887692

FBXL6
F-box/LRR-repeat protein 6

1

2

High-throughput

0.437

High

887701

DDI1
Protein DDI1 homolog 1

1

20

High-throughput

0.437

High

887725

Q9H4D1
Receptor-interacting serine/threonine-protein kinase 4

1

2

High-throughput

0.437

High

887745

AAR2
Protein AAR2 homolog

1

1

High-throughput

0.437

High

887719

ZDHC5
Palmitoyltransferase ZDHHC5

1

0

High-throughput

0.426

High

886632

CEBPA
CCAAT/enhancer-binding protein alpha

1

8

High-throughput

0.408

High

694

A0A087WW66
26S proteasome non-ATPase regulatory subunit 1

1

20

High-throughput

0.407

High

887693

MOT11
Monocarboxylate transporter 11

1

7

High-throughput

0.407

High

887698

S35G2
Solute carrier family 35 member G2

1

0

High-throughput

0.232

Low

887709

S35A4
Probable UDP-sugar transporter protein SLC35A4

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025