HitPredict

Interactor 1: PSA1 (P25786)
Proteasome subunit alpha type-1 (30 kDa prosomal protein) (PROS-30) (Macropain subunit C2) (Multicatalytic endopeptidase complex subunit C2) (Proteasome component C2) (Proteasome nu chain)
Gene: PSMA1

Interactor 2: UBE3C (Q15386)
Ubiquitin-protein ligase E3C (EC 2.3.2.26) (HECT-type ubiquitin transferase E3C) (Homologous to E6AP carboxyl terminus homologous protein 2) (HectH2) (RTA-associated ubiquitin ligase) (RAUL)
Gene: UBE3C

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	35271311
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000502 - proteasome complex
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 263 Hs			1 1083
+	Hs
		656235 PSA5_HUMAN (1-236): 5.66e-93: 275: 28.81		UBE3C_HUMAN (1-1083): 0: 1136: 100.00
+	Hs
		893675 PSA6_HUMAN (1-240): 1.64e-92: 274: 25.00		UBE3C_HUMAN (1-1083): 0: 1136: 100.00
+	Hs
		637394 PSA1_HUMAN (1-263): 3.26e-109: 317: 100.00		UBE3A_HUMAN (384-1082): 0: 557: 21.73
+	Hs
		156366 PSA7_HUMAN (6-234): 9.99e-96: 282: 33.19		HECW2_HUMAN (262-1082): 0: 591: 19.91
+	Hs
		156275 PSA7_HUMAN (6-234): 9.99e-96: 282: 33.19		UBE3A_HUMAN (384-1082): 0: 557: 21.73
+	Hs
		656207 PSA5_HUMAN (1-236): 5.66e-93: 275: 28.81		UBE3A_HUMAN (384-1082): 0: 557: 21.73
+	Hs
		893654 PSA6_HUMAN (1-240): 1.64e-92: 274: 25.00		UBE3A_HUMAN (384-1082): 0: 557: 21.73
+	Hs
		638114 PSA4_HUMAN (1-233): 4.82e-91: 271: 28.75		UBE3A_HUMAN (384-1082): 0: 557: 21.73
+	Hs
		656320 PSA5_HUMAN (1-236): 5.66e-93: 275: 28.81		SMUF1_HUMAN (562-1080): 3.14e-177: 539: 22.78
+	Hs
		638201 PSA4_HUMAN (1-233): 4.82e-91: 271: 28.75		SMUF1_HUMAN (562-1080): 3.14e-177: 539: 22.78
+	Hs
		637468 PSA1_HUMAN (1-263): 3.26e-109: 317: 100.00		HUWE1_HUMAN (683-1083): 1.53e-47: 188: 32.60
+	Hs
		156320 PSA7_HUMAN (6-234): 9.99e-96: 282: 33.19		HUWE1_HUMAN (683-1083): 1.53e-47: 188: 32.60
+	Hs
		656264 PSA5_HUMAN (1-236): 5.66e-93: 275: 28.81		HUWE1_HUMAN (683-1083): 1.53e-47: 188: 32.60
+	Hs
		893701 PSA6_HUMAN (1-240): 1.64e-92: 274: 25.00		HUWE1_HUMAN (683-1083): 1.53e-47: 188: 32.60
+	Hs
		638160 PSA4_HUMAN (1-233): 4.82e-91: 271: 28.75		HUWE1_HUMAN (683-1083): 1.53e-47: 188: 32.60
+	Sc
		771350 PSA6_YEAST (1-233): 3.26e-83: 250: 52.77		TOM1_YEAST (683-1083): 1.4e-46: 185: 32.12