HitPredict

Interactor 1: TNR5 (P25942)
Tumor necrosis factor receptor superfamily member 5 (B-cell surface antigen CD40) (Bp50) (CD40L receptor) (CDw40) (CD antigen CD40)
Gene: CD40

Interactor 2: JAK3 (P52333)
Tyrosine-protein kinase JAK3 (EC 2.7.10.2) (Janus kinase 3) (JAK-3) (Leukocyte janus kinase) (L-JAK)
Gene: JAK3

Species: Homo sapiens

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.44	0.60	0.515

Property	Details
Experiments	9133417
Identification Methods	pull down, anti tag coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 277 Hs			1 1124
+	Hs
		238354 TNR1A_HUMAN (23-251): 1.84e-39: 144: 20.59		JAK2_HUMAN (7-1101): 0: 889: 47.80
+	Mm
		192581 TNR11_MOUSE (7-219): 4.42e-59: 200: 37.09		LYN_MOUSE (781-1110): 2.99e-92: 306: 28.10
+	Hs
		154294 TR10B_HUMAN (13-273): 6.41e-48: 166: 17.90		FYN_HUMAN (790-1109): 4.99e-97: 320: 29.60
+	Hs
		522761 TNR1A_HUMAN (23-251): 1.84e-39: 144: 20.59		SRC_HUMAN (793-1109): 4.7e-100: 328: 29.25
+	Hs
		522788 TNR6_HUMAN (12-145): 1.56e-35: 131: 27.94		SRC_HUMAN (793-1109): 4.7e-100: 328: 29.25
+	Hs
		433256 TNR6_HUMAN (12-145): 1.56e-35: 131: 27.94		YES_HUMAN (784-1109): 7.17e-99: 326: 29.36
+	Hs
		411601 TNR6_HUMAN (12-145): 1.56e-35: 131: 27.94		LCK_HUMAN (794-1110): 1.37e-97: 321: 30.50
+	Hs
		412024 TNR6_HUMAN (12-145): 1.56e-35: 131: 27.94		FYN_HUMAN (790-1109): 4.99e-97: 320: 29.60
+	Mm
		411916 TNR9_MOUSE (35-262): 7.48e-33: 122: 20.08		LCK_MOUSE (794-1110): 3.91e-98: 323: 30.50
+	Mm
		591446 TNR9_MOUSE (35-262): 7.48e-33: 122: 20.08		FYN_MOUSE (790-1109): 6.19e-97: 320: 29.60
+	Hs
		584315 TNR1A_HUMAN (23-251): 1.84e-39: 144: 20.59		JAK1_HUMAN (761-1119): 1.21e-38: 158: 18.62
+	Hs
		339213 TNR11_HUMAN (22-219): 4.69e-56: 192: 36.87		EGFR_HUMAN (527-780): 3.22e-18: 92.8: 24.34
+	Mm
		626887 TNR1B_MOUSE (12-251): 1.82e-56: 190: 23.48		NTRK1_MOUSE (500-780): 8.06e-14: 78.2: 24.18
+	Hs
		154290 TR10B_HUMAN (13-273): 6.41e-48: 166: 17.90		EGFR_HUMAN (527-780): 3.22e-18: 92.8: 24.34
+	Hs
		616887 EDAR_HUMAN (105-218): 8.41e-18: 84.5: 20.34		JAK1_HUMAN (761-1119): 1.21e-38: 158: 18.62
+	Mm
		626854 TNR1A_MOUSE (23-249): 2.31e-41: 149: 22.27		KSYK_MOUSE (520-773): 7.4e-18: 90.9: 27.38
+	Hs
		337916 TNR1A_HUMAN (23-251): 1.84e-39: 144: 20.59		EGFR_HUMAN (527-780): 3.22e-18: 92.8: 24.34
+	Hs
		584342 TNR1A_HUMAN (23-251): 1.84e-39: 144: 20.59		KSYK_HUMAN (525-773): 5e-18: 91.3: 27.13
+	Hs
		669204 TNR19_HUMAN (7-142): 1.42e-19: 89.5: 18.62		TYK2_HUMAN (828-1122): 5.53e-34: 144: 20.62
+	Rn
		421808 TNR16_RAT (25-198): 2.03e-36: 135: 22.47		NTRK1_RAT (500-780): 9.24e-14: 78.2: 24.18