Protein: RIR2
Ribonucleoside-diphosphate reductase small chain 1 (EC 1.17.4.1) (Ribonucleotide reductase R2 subunit 1) (Ribonucleotide reductase small subunit 1)

Gene: RIR2, RNR2
Organism: Saccharomyces cerevisiae S288C
Interactions: 73
UniProt ID: P09938

Gene Ontology (top 5):
GO:0004748 - ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor
GO:0005634 - nucleus
GO:0005737 - cytoplasm
GO:0005971 - ribonucleoside-diphosphate reductase complex
GO:0008198 - ferrous iron binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

488625

RIR4
Ribonucleoside-diphosphate reductase small chain 2

13

15

Small-scale

0.984

High

488589

RIR1
Ribonucleoside-diphosphate reductase large chain 1

4

14

Small-scale

0.893

High

488578

RIR2
Ribonucleoside-diphosphate reductase small chain 1

4

15

Small-scale

0.879

High

488579

HSP71
Heat shock protein SSA1

6

6

Small-scale

0.718

High

488640

WTM1
Transcriptional modulator WTM1

5

3

Small-scale

0.716

High

488639

WTM2
Transcriptional modulator WTM2

4

3

Small-scale

0.697

High

488595

HS104
Heat shock protein 104

3

3

High-throughput

0.633

High

488580

HSP72
Heat shock protein SSA2

3

6

Small-scale

0.629

High

488581

SSB1
Ribosome-associated molecular chaperone SSB1

3

6

High-throughput

0.624

High

488596

ASF1
Histone chaperone ASF1

2

1

High-throughput

0.601

High

488582

NHP6B
Non-histone chromosomal protein 6B

2

0

High-throughput

0.563

High

488613

SWD1
COMPASS component SWD1

1

1

High-throughput

0.536

High

488619

SMK1
Sporulation-specific mitogen-activated protein kinase SMK1

1

1

High-throughput

0.536

High

488644

HUG1
MEC1-mediated checkpoint protein HUG1

1

1

Small-scale

0.527

High

488590

SIS1
Protein SIS1

1

3

High-throughput

0.515

High

449267

RAD10
DNA repair protein RAD10

1

0

High-throughput

0.513

High

475096

CYAA
Adenylate cyclase

1

0

High-throughput

0.513

High

488588

PP11
Serine/threonine-protein phosphatase PP1-1

1

0

High-throughput

0.513

High

488598

SMC1
Structural maintenance of chromosomes protein 1

1

0

High-throughput

0.513

High

488606

DBP8
ATP-dependent RNA helicase DBP8

1

0

High-throughput

0.513

High

488618

DPH1
2-(3-amino-3-carboxypropyl)histidine synthase subunit 1

1

0

High-throughput

0.513

High

150332

DIF1
Damage-regulated import facilitator 1

1

1

Small-scale

0.501

High

444815

SIR3
Regulatory protein SIR3

1

1

High-throughput

0.489

High

488630

UTP5
U3 small nucleolar RNA-associated protein 5

1

1

High-throughput

0.489

High

488623

CTH1
mRNA decay factor CTH1

1

3

Small-scale

0.481

High

488624

CTH2
mRNA decay factor CTH2

1

3

Small-scale

0.481

High

488615

RSP5
E3 ubiquitin-protein ligase RSP5

1

0

Small-scale

0.480

High

392056

HSP82
ATP-dependent molecular chaperone HSP82

1

6

High-throughput

0.479

High

488583

HSC82
ATP-dependent molecular chaperone HSC82

1

6

High-throughput

0.479

High

488585

RPB3
DNA-directed RNA polymerase II subunit RPB3

1

1

High-throughput

0.479

High

488591

MAS5
Mitochondrial protein import protein MAS5

1

2

Small-scale

0.479

High

488592

CDC48
Cell division control protein 48

1

3

High-throughput

0.479

High

488593

TF2B
Transcription initiation factor IIB

1

1

High-throughput

0.479

High

488594

MCM4
DNA replication licensing factor MCM4

1

2

Small-scale

0.479

High

488602

SRX1
Sulfiredoxin

1

1

High-throughput

0.479

High

488607

RPN1
26S proteasome regulatory subunit RPN1

1

1

High-throughput

0.479

High

488608

RPN10
26S proteasome regulatory subunit RPN10

1

1

High-throughput

0.479

High

488610

UME6
Transcriptional regulatory protein UME6

1

1

High-throughput

0.479

High

488614

IF4F1
Eukaryotic initiation factor 4F subunit p150

1

1

High-throughput

0.479

High

488622

RPN11
Ubiquitin carboxyl-terminal hydrolase RPN11

1

1

High-throughput

0.479

High

488627

PIL1
Sphingolipid long chain base-responsive protein PIL1

1

1

High-throughput

0.479

High

488628

UBP10
Ubiquitin carboxyl-terminal hydrolase 10

1

2

High-throughput

0.479

High

488633

MMS22
E3 ubiquitin-protein ligase substrate receptor MMS22

1

1

High-throughput

0.479

High

488634

TFC6
Transcription factor tau 91 kDa subunit

1

1

High-throughput

0.479

High

488637

YO283
Broad-specificity phosphatase YOR283W

1

2

High-throughput

0.479

High

488638

YL11B
Transposon Ty1-LR1 Gag-Pol polyprotein

1

1

High-throughput

0.479

High

488587

MYO2
Myosin-2

1

0

Small-scale

0.460

High

488599

SMY2
Protein SMY2

1

0

High-throughput

0.458

High

488600

PRS6A
26S proteasome regulatory subunit 6A

1

0

High-throughput

0.458

High

488603

DRE2
Fe-S cluster assembly protein DRE2

1

0

Small-scale

0.458

High

488605

ATG8
Autophagy-related protein 8

1

0

High-throughput

0.458

High

488635

VAM6
Vacuolar morphogenesis protein 6

1

0

High-throughput

0.458

High

488643

RRP12
Ribosomal RNA-processing protein 12

1

0

Small-scale

0.458

High

488621

BNI1
Protein BNI1

1

1

High-throughput

0.457

High

488584

VATB
V-type proton ATPase subunit B

1

1

High-throughput

0.445

High

488597

HSP7F
Heat shock protein homolog SSE1

1

10

High-throughput

0.445

High

488601

HSP78
Heat shock protein 78, mitochondrial

1

3

High-throughput

0.445

High

488611

YM11
Uncharacterized protein YMR124W

1

1

High-throughput

0.445

High

488616

SSB2
Ribosome-associated molecular chaperone SSB2

1

6

High-throughput

0.445

High

488604

RPF2
Ribosome biogenesis protein RPF2

1

1

High-throughput

0.437

High

488617

MLP2
Protein MLP2

1

2

High-throughput

0.437

High

488629

MLP1
Protein MLP1

1

2

High-throughput

0.437

High

488636

AP3D
AP-3 complex subunit delta

1

1

High-throughput

0.437

High

488641

DBP10
ATP-dependent RNA helicase DBP10

1

1

High-throughput

0.437

High

488642

SET6
Potential protein lysine methyltransferase SET6

1

0

High-throughput

0.426

High

488609

TEM1
Protein TEM1

1

0

High-throughput

0.279

Low

488620

COPB2
Coatomer subunit beta'

1

0

High-throughput

0.279

Low

488631

SEN15
tRNA-splicing endonuclease subunit SEN15

1

0

High-throughput

0.279

Low

488586

SPO16
Sporulation-specific protein 16

1

0

Small-scale

0.249

Low

488612

LAA1
AP-1 accessory protein LAA1

1

0

High-throughput

0.249

Low

488626

PRM8
Pheromone-regulated membrane protein 8

1

0

High-throughput

0.232

Low

488632

SPC2
Signal peptidase complex subunit 2

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025