Protein: RIR2
Ribonucleoside-diphosphate reductase subunit M2 (EC 1.17.4.1) (Ribonucleotide reductase small chain) (Ribonucleotide reductase small subunit)

Gene: RIR2, RRM2
Organism: Homo sapiens
Interactions: 85
UniProt ID: P31350

Gene Ontology (top 5):
GO:0001824 - blastocyst development
GO:0004748 - ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor
GO:0005654 - nucleoplasm
GO:0005829 - cytosol
GO:0005971 - ribonucleoside-diphosphate reductase complex

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

663386

RIR1
Ribonucleoside-diphosphate reductase large subunit

10

14

Small-scale

0.976

High

725790

RIR2B
Ribonucleoside-diphosphate reductase subunit M2 B

5

15

High-throughput

0.919

High

725817

FZR1
Fizzy-related protein homolog

6

3

Small-scale

0.732

High

725770

CCNF
Cyclin-F

5

0

Small-scale

0.682

High

536591

HSP7C
Heat shock cognate 71 kDa protein

4

1

High-throughput

0.678

High

187298

SHIP2
Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2

3

1

High-throughput

0.667

High

718505

CDC27
Cell division cycle protein 27 homolog

3

2

High-throughput

0.667

High

725765

RIR2
Ribonucleoside-diphosphate reductase subunit M2

1

15

Small-scale

0.647

High

725815

APC4
Anaphase-promoting complex subunit 4

3

0

High-throughput

0.638

High

140151

SDCB1
Syntenin-1

2

0

High-throughput

0.580

High

275873

UBP12
Ubiquitin carboxyl-terminal hydrolase 12

1

0

Small-scale

0.537

High

243896

JIP4
C-Jun-amino-terminal kinase-interacting protein 4

1

1

High-throughput

0.536

High

346871

BAG2
BAG family molecular chaperone regulator 2

1

1

High-throughput

0.536

High

725779

CDC16
Cell division cycle protein 16 homolog

1

2

High-throughput

0.536

High

725814

CDC23
Cell division cycle protein 23 homolog

1

2

High-throughput

0.536

High

725780

SKP2
S-phase kinase-associated protein 2

1

0

Small-scale

0.529

High

413271

P53
Cellular tumor antigen p53

1

1

Small-scale

0.523

High

291757

STK16
Serine/threonine-protein kinase 16

1

0

High-throughput

0.513

High

539952

BCR
Breakpoint cluster region protein

1

0

High-throughput

0.513

High

563280

CFTR
Cystic fibrosis transmembrane conductance regulator

1

0

High-throughput

0.513

High

593029

CREB1
Cyclic AMP-responsive element-binding protein 1

1

0

High-throughput

0.513

High

725774

APC15
Anaphase-promoting complex subunit 15

1

0

High-throughput

0.513

High

725789

FBX50
F-box only protein 50

1

0

High-throughput

0.513

High

725805

SLK
STE20-like serine/threonine-protein kinase

1

0

High-throughput

0.513

High

725811

SDHF2
Succinate dehydrogenase assembly factor 2, mitochondrial

1

0

High-throughput

0.513

High

725818

M3K2
Mitogen-activated protein kinase kinase kinase 2

1

0

High-throughput

0.513

High

725796

KAT5
Histone acetyltransferase KAT5

1

1

Small-scale

0.501

High

135516

DNM1L
Dynamin-1-like protein

1

0

Small-scale

0.486

High

725806

PLK3
Serine/threonine-protein kinase PLK3

1

3

Small-scale

0.481

High

411440

NTRK1
High affinity nerve growth factor receptor

1

3

High-throughput

0.479

High

461188

HS90A
Heat shock protein HSP 90-alpha

1

6

High-throughput

0.479

High

725766

STIP1
Stress-induced-phosphoprotein 1

1

2

High-throughput

0.479

High

725767

HSP74
Heat shock 70 kDa protein 4

1

4

High-throughput

0.479

High

725772

PLK1
Serine/threonine-protein kinase PLK1

1

3

High-throughput

0.479

High

725773

TERA
Transitional endoplasmic reticulum ATPase

1

3

High-throughput

0.479

High

725775

1433G
14-3-3 protein gamma

1

1

High-throughput

0.479

High

725778

1433F
14-3-3 protein eta

1

1

High-throughput

0.479

High

725782

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1

1

High-throughput

0.479

High

725792

SIR6
NAD-dependent protein deacylase sirtuin-6

1

1

High-throughput

0.479

High

725794

NUP43
Nucleoporin Nup43

1

1

High-throughput

0.479

High

240863

PRKN
E3 ubiquitin-protein ligase parkin

1

0

High-throughput

0.458

High

289936

OFD1
Centriole and centriolar satellite protein OFD1

1

0

High-throughput

0.458

High

371277

MYC
Myc proto-oncogene protein

1

0

High-throughput

0.458

High

385490

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

1

0

High-throughput

0.458

High

519779

ANDR
Androgen receptor

1

0

High-throughput

0.458

High

588006

RFA2
Replication protein A 32 kDa subunit

1

0

High-throughput

0.458

High

606302

CEBPB
CCAAT/enhancer-binding protein beta

1

0

High-throughput

0.458

High

694718

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

0

High-throughput

0.458

High

713891

PML
Protein PML

1

0

High-throughput

0.458

High

725768

RFA3
Replication protein A 14 kDa subunit

1

0

High-throughput

0.458

High

725776

PPIA
Peptidyl-prolyl cis-trans isomerase A

1

0

High-throughput

0.458

High

725781

SQSTM
Sequestosome-1

1

0

High-throughput

0.458

High

725783

RBM39
RNA-binding protein 39

1

0

High-throughput

0.458

High

725784

PCM1
Pericentriolar material 1 protein

1

0

High-throughput

0.458

High

725785

STIL
SCL-interrupting locus protein

1

0

High-throughput

0.458

High

725787

CE170
Centrosomal protein of 170 kDa

1

0

High-throughput

0.458

High

725795

BICD2
Protein bicaudal D homolog 2

1

0

High-throughput

0.458

High

725798

CI072
Guanine nucleotide exchange factor C9orf72

1

0

High-throughput

0.458

High

725799

SCLT1
Sodium channel and clathrin linker 1

1

0

High-throughput

0.458

High

725800

NR1H4
Bile acid receptor

1

0

Small-scale

0.458

High

725804

TOLIP
Toll-interacting protein

1

0

High-throughput

0.458

High

725812

MKS1
Tectonic-like complex member MKS1

1

0

High-throughput

0.458

High

725813

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.458

High

443215

CDK1
Cyclin-dependent kinase 1

1

1

Small-scale

0.445

High

725801

TS101
Tumor susceptibility gene 101 protein

1

0

High-throughput

0.438

High

352334

TOP3B
DNA topoisomerase 3-beta-1

1

1

High-throughput

0.437

High

463907

RET
Proto-oncogene tyrosine-protein kinase receptor Ret

1

3

High-throughput

0.437

High

648435

FGFR4
Fibroblast growth factor receptor 4

1

4

High-throughput

0.437

High

725769

HSPA9
Stress-70 protein, mitochondrial

1

3

High-throughput

0.437

High

725788

TRI67
Tripartite motif-containing protein 67

1

1

High-throughput

0.437

High

725816

CLC4E
C-type lectin domain family 4 member E

1

2

High-throughput

0.437

High

725777

E2F1
Transcription factor E2F1

1

0

High-throughput

0.426

High

725808

S40A1
Ferroportin

1

0

High-throughput

0.426

High

725771

GPC3
Glypican-3

1

1

High-throughput

0.407

High

725797

FAF2
FAS-associated factor 2

4

0

High-throughput

0.362

High

725786

NCBP3
Nuclear cap-binding protein subunit 3

1

0

High-throughput

0.279

Low

725791

HORN
Hornerin

1

0

High-throughput

0.279

Low

725803

PITH1
PITH domain-containing protein 1

1

0

High-throughput

0.279

Low

725810

TM248
Transmembrane protein 248

1

0

High-throughput

0.279

Low

293270

CD123
Translation initiation factor eIF2 assembly protein

1

0

High-throughput

0.249

Low

725793

POC1A
POC1 centriolar protein homolog A

1

0

High-throughput

0.249

Low

725807

PKHA4
Pleckstrin homology domain-containing family A member 4

1

0

High-throughput

0.249

Low

725809

KBTB4
Kelch repeat and BTB domain-containing protein 4

1

0

High-throughput

0.249

Low

725802

MGME1
Mitochondrial genome maintenance exonuclease 1

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025