Protein: RIR2
Ribonucleoside-diphosphate reductase subunit M2 (EC 1.17.4.1) (Ribonucleotide reductase small subunit)

Gene: RIR2, RnrS
Organism: Drosophila melanogaster
Interactions: 164
UniProt ID: P48592

Gene Ontology (top 5):
GO:0004748 - ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor
GO:0005829 - cytosol
GO:0005971 - ribonucleoside-diphosphate reductase complex
GO:0009263 - deoxyribonucleotide biosynthetic process
GO:0046872 - metal ion binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

874621

RIR1
Ribonucleoside-diphosphate reductase large subunit

1

14

High-throughput

0.575

High

235083

A29AB
Accessory gland protein Acp29AB

1

2

High-throughput

0.464

High

53981

A1Z892
1-Cys peroxiredoxin

1

1

High-throughput

0.445

High

121193

ALDR
Aldo-keto reductase 1B

1

4

High-throughput

0.445

High

871596

FKB12
Peptidyl-prolyl cis-trans isomerase Fkbp12

1

3

High-throughput

0.445

High

874630

DOD
Putative peptidyl-prolyl cis-trans isomerase dodo

1

1

High-throughput

0.445

High

874633

TRXR1
Thioredoxin reductase 1, mitochondrial

1

1

High-throughput

0.445

High

874644

Q7JVH6
LD24696p

1

4

High-throughput

0.445

High

874645

Q7JX87
1-Cys peroxiredoxin

1

1

High-throughput

0.445

High

874648

Q7K0E6
Aspartate--tRNA ligase, cytoplasmic

1

1

High-throughput

0.445

High

874652

TERA
Transitional endoplasmic reticulum ATPase TER94

1

3

High-throughput

0.445

High

874680

THIO2
Thioredoxin-2

1

1

High-throughput

0.445

High

874682

PSA3
Proteasome subunit alpha type-3

1

1

High-throughput

0.445

High

874688

Q9VAN7
Phosphoglycerate mutase

1

2

High-throughput

0.445

High

874703

Q9VHX4
LD24679p

1

4

High-throughput

0.445

High

874708

Q9VKW5
Prolyl endopeptidase

1

1

High-throughput

0.445

High

874713

Q9VLB7
Rab GDP dissociation inhibitor

1

1

High-throughput

0.445

High

874717

PSB4
Proteasome subunit beta type-4

1

1

High-throughput

0.445

High

874723

Q9VRL1
GEO06356p1

1

1

High-throughput

0.445

High

874727

Q9VTY2
Uncharacterized protein, isoform A

1

4

High-throughput

0.445

High

874729

Q9VUC1
Hsc70Cb, isoform A

1

5

High-throughput

0.445

High

874736

CLIC
Chloride intracellular channel Clic

1

1

High-throughput

0.445

High

874747

WUHO
tRNA

1

1

High-throughput

0.445

High

874750

PSB3
Proteasome subunit beta type-3

1

1

High-throughput

0.445

High

874753

PSA6
Proteasome subunit alpha type-6

1

2

High-throughput

0.445

High

874755

Q9Y112
BcDNA.GH10614

1

4

High-throughput

0.445

High

52192

A1Z6Q0
Klaroid, isoform D

1

1

High-throughput

0.439

High

874657

Q7KVF3
Uncharacterized protein

1

1

High-throughput

0.439

High

357264

O97428
Ciboulot, isoform A

1

0

High-throughput

0.426

High

460006

ALF
Fructose-bisphosphate aldolase

1

0

High-throughput

0.426

High

556648

PSA1
Proteasome subunit alpha type-1

1

0

High-throughput

0.426

High

578049

ENO
Enolase

1

0

High-throughput

0.426

High

821819

PSA2
Proteasome subunit alpha type-2

1

0

High-throughput

0.426

High

835126

6PGD
6-phosphogluconate dehydrogenase, decarboxylating

1

0

High-throughput

0.426

High

855975

MOEH
Moesin/ezrin/radixin homolog 1

1

0

High-throughput

0.426

High

874634

PGK
Phosphoglycerate kinase

1

0

High-throughput

0.426

High

874637

Q0E993
Valine--tRNA ligase

1

0

High-throughput

0.426

High

874640

SAHH
Adenosylhomocysteinase

1

0

High-throughput

0.426

High

874649

Q7K148
Proteasome subunit beta

1

0

High-throughput

0.426

High

874653

Q7KN85
ATP-citrate synthase

1

0

High-throughput

0.426

High

874656

Q7KTW5
Inositol-1-monophosphatase

1

0

High-throughput

0.426

High

874659

Q8INK3
Fatty acid-binding protein, muscle

1

0

High-throughput

0.426

High

874660

Q8IQZ7
FI19014p1

1

0

High-throughput

0.426

High

874661

Q8IRD3
Glutathione peroxidase

1

0

High-throughput

0.426

High

874662

Q8MT58
Carnosine dipeptidase 2, isoform A

1

0

High-throughput

0.426

High

874665

OLA1
Obg-like ATPase 1

1

0

High-throughput

0.426

High

874672

JUPIT
Microtubule-associated protein Jupiter

1

0

High-throughput

0.426

High

874674

PUR6
Bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase

1

0

High-throughput

0.426

High

874676

PSMD6
26S proteasome non-ATPase regulatory subunit 6

1

0

High-throughput

0.426

High

874686

Q9VAC1
GM14349p

1

0

High-throughput

0.426

High

874692

Q9VCK6
LD34157p

1

0

High-throughput

0.426

High

874693

Q9VD02
GH14779p

1

0

High-throughput

0.426

High

874696

FLNA
Filamin-A

1

0

High-throughput

0.426

High

874699

Q9VH81
protein-serine/threonine phosphatase

1

0

High-throughput

0.426

High

874700

TEBPH
Cytosolic Prostaglandin E synthase

1

0

High-throughput

0.426

High

874701

Q9VHN7
transketolase

1

0

High-throughput

0.426

High

874702

DPP3
Dipeptidyl peptidase 3

1

0

High-throughput

0.426

High

874704

Q9VIE8
Aconitate hydratase, mitochondrial

1

0

High-throughput

0.426

High

874709

EF1D
Probable elongation factor 1-delta

1

0

High-throughput

0.426

High

874714

AK200
A-kinase anchor protein 200

1

0

High-throughput

0.426

High

874725

Q9VSI6
Isocitrate dehydrogenase [NADP]

1

0

High-throughput

0.426

High

874728

Q9VU35
10 kDa heat shock protein, mitochondrial

1

0

High-throughput

0.426

High

874732

Q9VW59
Rho GDP-dissociation inhibitor 3

1

0

High-throughput

0.426

High

874742

SND1
Staphylococcal nuclease domain-containing protein 1

1

0

High-throughput

0.426

High

52243

A1Z6Q1
Klaroid, isoform B

1

1

High-throughput

0.417

High

874666

Q8SX59
LD42296p

1

1

High-throughput

0.417

High

57531

A1ZB71
Glutathione S transferase E6

1

1

High-throughput

0.407

High

648866

ANXB9
Annexin B9

1

1

High-throughput

0.407

High

649013

ANX10
Annexin B10

1

1

High-throughput

0.407

High

874631

PDI
Protein disulfide-isomerase

1

2

High-throughput

0.407

High

874639

NLP
Nucleoplasmin-like protein

1

1

High-throughput

0.407

High

874641

Q3YMU0
Protein disulfide-isomerase

1

1

High-throughput

0.407

High

874664

Q8STA5
Histidine triad nucleotide binding protein 1, isoform A

1

1

High-throughput

0.407

High

874678

Q9V3V2
peptidylprolyl isomerase

1

3

High-throughput

0.407

High

874681

PDIA6
Protein disulfide-isomerase A6 homolog

1

2

High-throughput

0.407

High

874687

Q9VAC4
GEO09167p1

1

1

High-throughput

0.407

High

874689

Q9VAY2
Heat shock protein 83

1

6

High-throughput

0.407

High

874697

Q9VGK3
peptidylprolyl isomerase

1

3

High-throughput

0.407

High

874706

Q9VJD4
LD24721p

1

3

High-throughput

0.407

High

874710

Q9VL68
Enoyl-CoA delta isomerase 1, mitochondrial

1

1

High-throughput

0.407

High

874712

FKB59
FK506-binding protein 59

1

2

High-throughput

0.407

High

874715

SYAC
Alanine--tRNA ligase, cytoplasmic

1

1

High-throughput

0.407

High

874719

Q9VPN5
Stress-induced-phosphoprotein 1

1

2

High-throughput

0.407

High

874726

Q9VSL2
Glutathione S transferase O3

1

1

High-throughput

0.407

High

874731

Q9VVL7
Dihydrolipoyl dehydrogenase

1

1

High-throughput

0.407

High

874737

TXND5
Thioredoxin domain-containing protein 5 homolog

1

3

High-throughput

0.407

High

874740

Q9W022
GEO01508p1

1

2

High-throughput

0.407

High

874743

Q9W227
Peptidyl-prolyl cis-trans isomerase

1

1

High-throughput

0.407

High

874744

Q9W3X6
fumarate hydratase

1

1

High-throughput

0.407

High

874746

CISY
Probable citrate synthase, mitochondrial

1

1

High-throughput

0.407

High

874751

Q9XYZ9
Glutathione S transferase E12, isoform A

1

1

High-throughput

0.407

High

874655

Q7KS72
C15

2

0

High-throughput

0.310

High

874658

TULP
Protein king tubby

2

0

High-throughput

0.298

High

874734

NEMP
Nuclear envelope integral membrane protein

2

0

High-throughput

0.298

High

58032

A1ZBD8
Mucin-5AC

1

0

High-throughput

0.265

Low

874691

Q9VCC9
LD23779p

1

0

High-throughput

0.265

Low

874705

Q9VIT3
LD32040p

1

0

High-throughput

0.265

Low

84687

B7Z0B8
Farmer, isoform I

1

0

High-throughput

0.249

Low

753697

FAT
Cadherin-related tumor suppressor

1

0

High-throughput

0.249

Low

874635

UMPS
Uridine 5'-monophosphate synthase

1

0

High-throughput

0.249

Low

57754

A1ZB77
Uncharacterized protein, isoform J

1

0

High-throughput

0.232

Low

86463

B9EQV3
Endoplasmic reticulum transmembrane protein

1

0

High-throughput

0.232

Low

145955

UGDH
UDP-glucose 6-dehydrogenase

1

0

High-throughput

0.232

Low

195010

O16043
Anon1A4

1

0

High-throughput

0.232

Low

197740

HCD2
3-hydroxyacyl-CoA dehydrogenase type-2

1

0

High-throughput

0.232

Low

234548

VINC
Vinculin

1

0

High-throughput

0.232

Low

304603

RS21
Small ribosomal subunit protein eS21

1

0

High-throughput

0.232

Low

305179

TRMB
tRNA

1

0

High-throughput

0.232

Low

305640

IPYR
Inorganic pyrophosphatase

1

0

High-throughput

0.232

Low

356312

O97102
Small ubiquitin-related modifier

1

0

High-throughput

0.232

Low

357476

INO1
Inositol-3-phosphate synthase

1

0

High-throughput

0.232

Low

426644

HP1
Heterochromatin protein 1

1

0

High-throughput

0.232

Low

476915

NDKA
Nucleoside diphosphate kinase

1

0

High-throughput

0.232

Low

609370

PCNA
Proliferating cell nuclear antigen

1

0

High-throughput

0.232

Low

632943

GLNA1
Glutamine synthetase 1, mitochondrial

1

0

High-throughput

0.232

Low

682716

PROF
Profilin

1

0

High-throughput

0.232

Low

712327

CALR
Calreticulin

1

0

High-throughput

0.232

Low

762520

UCHL
Ubiquitin carboxyl-terminal hydrolase

1

0

High-throughput

0.232

Low

874632

VATE
V-type proton ATPase subunit E

1

0

High-throughput

0.232

Low

874636

ATPB
ATP synthase subunit beta, mitochondrial

1

0

High-throughput

0.232

Low

874638

Q0KHZ6
Electron transfer flavoprotein subunit beta

1

0

High-throughput

0.232

Low

874642

Q76NR6
Regucalcin

1

0

High-throughput

0.232

Low

874643

Q7JR58
Probable enoyl-CoA hydratase, mitochondrial

1

0

High-throughput

0.232

Low

874646

Q7JXC4
CG6459 protein

1

0

High-throughput

0.232

Low

874647

SEELE
Protein seele

1

0

High-throughput

0.232

Low

874650

Q7K2K2
FI04612p

1

0

High-throughput

0.232

Low

874651

EIF3J
Eukaryotic translation initiation factor 3 subunit J

1

0

High-throughput

0.232

Low

874654

Q7KN99
Phosphopantothenoylcysteine synthetase, isoform A

1

0

High-throughput

0.232

Low

874663

Q8MYY7
RE44624p

1

0

High-throughput

0.232

Low

874667

Q8T0L3
E1 ubiquitin-activating enzyme

1

0

High-throughput

0.232

Low

874668

NACA
Nascent polypeptide-associated complex subunit alpha

1

0

High-throughput

0.232

Low

874669

ACPM
Acyl carrier protein, mitochondrial

1

0

High-throughput

0.232

Low

874670

FAXC
Failed axon connections

1

0

High-throughput

0.232

Low

874671

IF5A
Eukaryotic translation initiation factor 5A

1

0

High-throughput

0.232

Low

874673

NASP
Nuclear autoantigenic sperm protein homolog

1

0

High-throughput

0.232

Low

874675

SH3BG
SH3 domain-binding glutamic acid-rich protein homolog

1

0

High-throughput

0.232

Low

874677

Q9V3I1
Deoxyuridine 5'-triphosphate nucleotidohydrolase

1

0

High-throughput

0.232

Low

874679

Q9V3V9
Endonuclease G inhibitor, isoform A

1

0

High-throughput

0.232

Low

874683

AN32A
Acidic leucine-rich nuclear phosphoprotein 32 family member A

1

0

High-throughput

0.232

Low

874684

Q9V9S0
FI04419p

1

0

High-throughput

0.232

Low

874685

Q9V9U3
LD45254p

1

0

High-throughput

0.232

Low

874690

Q9VBR6
RE74917p

1

0

High-throughput

0.232

Low

874694

Q9VD29
small monomeric GTPase

1

0

High-throughput

0.232

Low

874695

Q9VEB1
Malate dehydrogenase, mitochondrial

1

0

High-throughput

0.232

Low

874698

TCTP
Translationally-controlled tumor protein homolog

1

0

High-throughput

0.232

Low

874707

Q9VKB0
threonine--tRNA ligase

1

0

High-throughput

0.232

Low

874711

Q9VL70
HL08109p

1

0

High-throughput

0.232

Low

874716

Q9VMU6
LD31822p

1

0

High-throughput

0.232

Low

874718

Q9VNB2
RE42193p

1

0

High-throughput

0.232

Low

874720

Q9VPX6
Adenylyl cyclase-associated protein

1

0

High-throughput

0.232

Low

874721

BACC
Bacchus

1

0

High-throughput

0.232

Low

874722

Q9VRD6
NTF2-related export protein

1

0

High-throughput

0.232

Low

874724

Q9VRP2
Uncharacterized protein, isoform A

1

0

High-throughput

0.232

Low

874730

Y9705
Cold shock domain-containing protein CG9705

1

0

High-throughput

0.232

Low

874733

RS10B
Small ribosomal subunit protein eS10B

1

0

High-throughput

0.232

Low

874735

DHB4
Peroxisomal multifunctional enzyme type 2

1

0

High-throughput

0.232

Low

874738

Q9VZI1
Transgelin

1

0

High-throughput

0.232

Low

874739

Q9VZY0
LD45195p

1

0

High-throughput

0.232

Low

874741

Q9W0H8
Reticulocalbin-3

1

0

High-throughput

0.232

Low

874745

Q9W3Y3
Calcyclin-binding protein

1

0

High-throughput

0.232

Low

874748

Q9W457
Serine hydroxymethyltransferase

1

0

High-throughput

0.232

Low

874749

Q9W478
RE43153p

1

0

High-throughput

0.232

Low

874752

Q9XZ57
Eb1, isoform E

1

0

High-throughput

0.232

Low

874754

PURA
Adenylosuccinate synthetase

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025