Protein: RIR2B
Ribonucleoside-diphosphate reductase subunit M2 B (EC 1.17.4.1) (TP53-inducible ribonucleotide reductase M2 B) (p53-inducible ribonucleotide reductase small subunit 2-like protein) (p53R2)

Gene: RIR2B, RRM2B
Organism: Homo sapiens
Interactions: 60
UniProt ID: Q7LG56

Gene Ontology (top 5):
GO:0000731 - DNA synthesis involved in DNA repair
GO:0001822 - kidney development
GO:0003014 - renal system process
GO:0004748 - ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor
GO:0005654 - nucleoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

663427

RIR1
Ribonucleoside-diphosphate reductase large subunit

5

14

Small-scale

0.923

High

725790

RIR2
Ribonucleoside-diphosphate reductase subunit M2

5

15

High-throughput

0.919

High

1273216

RIR2B
Ribonucleoside-diphosphate reductase subunit M2 B

5

15

Small-scale

0.912

High

187368

SHIP2
Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2

3

1

High-throughput

0.667

High

1273236

FZR1
Fizzy-related protein homolog

3

3

High-throughput

0.662

High

414095

P53
Cellular tumor antigen p53

2

1

Small-scale

0.611

High

1102196

ATM
Serine-protein kinase ATM

1

0

Small-scale

0.567

High

1028256

MDM2
E3 ubiquitin-protein ligase Mdm2

1

0

Small-scale

0.564

High

997822

CSK21
Casein kinase II subunit alpha

1

1

Small-scale

0.561

High

231496

ORC4
Origin recognition complex subunit 4

1

0

High-throughput

0.557

High

1273230

RNF41
E3 ubiquitin-protein ligase NRDP1

1

0

High-throughput

0.549

High

243962

JIP4
C-Jun-amino-terminal kinase-interacting protein 4

1

1

High-throughput

0.536

High

347134

BAG2
BAG family molecular chaperone regulator 2

1

1

High-throughput

0.536

High

930959

HSP72
Heat shock-related 70 kDa protein 2

1

2

High-throughput

0.536

High

808108

CDN1A
Cyclin-dependent kinase inhibitor 1

1

0

Small-scale

0.529

High

464176

TPM2
Tropomyosin beta chain

1

0

High-throughput

0.513

High

1004760

RNF4
E3 ubiquitin-protein ligase RNF4

1

0

High-throughput

0.513

High

1273226

SOSB1
SOSS complex subunit B1

1

0

High-throughput

0.513

High

1273231

ENTP7
Ectonucleoside triphosphate diphosphohydrolase 7

1

0

High-throughput

0.513

High

1006497

SRPK2
SRSF protein kinase 2

1

0

High-throughput

0.480

High

262093

NBN
Nibrin

1

0

Small-scale

0.479

High

892888

MRE11
Double-strand break repair protein MRE11

1

0

Small-scale

0.479

High

1273223

RAD50
DNA repair protein RAD50

1

0

Small-scale

0.479

High

188917

TMPS2
Transmembrane protease serine 2

1

2

High-throughput

0.479

High

352474

TOP3B
DNA topoisomerase 3-beta-1

1

1

High-throughput

0.479

High

888155

MCM2
DNA replication licensing factor MCM2

1

2

High-throughput

0.479

High

920067

PLK1
Serine/threonine-protein kinase PLK1

1

3

High-throughput

0.479

High

1226951

A16L1
Autophagy-related protein 16-1

1

1

High-throughput

0.479

High

1273219

SIR6
NAD-dependent protein deacylase sirtuin-6

1

1

High-throughput

0.479

High

1273222

CLC4D
C-type lectin domain family 4 member D

1

2

High-throughput

0.479

High

488814

FURIN
Furin

1

0

High-throughput

0.458

High

774459

BASI
Basigin

1

0

High-throughput

0.458

High

913782

ZN131
Zinc finger protein 131

1

0

High-throughput

0.458

High

1273221

ATRIP
ATR-interacting protein

1

0

Small-scale

0.458

High

1273224

BROMI
Protein broad-minded

1

0

Small-scale

0.458

High

1273227

DDA1
DET1- and DDB1-associated protein 1

1

0

High-throughput

0.458

High

1273229

AICDA
Single-stranded DNA cytosine deaminase

1

0

Small-scale

0.458

High

641202

FGFR2
Fibroblast growth factor receptor 2

1

3

High-throughput

0.457

High

1273233

DDX28
Probable ATP-dependent RNA helicase DDX28

1

1

High-throughput

0.445

High

472087

MET
Hepatocyte growth factor receptor

1

1

High-throughput

0.437

High

693012

DPP4
Dipeptidyl peptidase 4

1

1

High-throughput

0.437

High

1254391

TRI67
Tripartite motif-containing protein 67

1

1

High-throughput

0.437

High

1273217

TM11B
Transmembrane protease serine 11B

1

2

High-throughput

0.437

High

1273232

TMPS4
Transmembrane protease serine 4

1

2

High-throughput

0.437

High

1273235

CLC4E
C-type lectin domain family 4 member E

1

2

High-throughput

0.437

High

1129243

LAGE3
EKC/KEOPS complex subunit LAGE3

1

0

High-throughput

0.426

High

906301

GPC3
Glypican-3

1

1

High-throughput

0.407

High

1273218

TTC9C
Tetratricopeptide repeat protein 9C

1

2

High-throughput

0.407

High

1273234

TMOD2
Tropomodulin-2

3

0

High-throughput

0.347

High

1150444

NHRF2
Na(+)/H(+) exchange regulatory cofactor NHE-RF2

2

0

High-throughput

0.313

High

955883

GMFB
Glia maturation factor beta

1

0

High-throughput

0.279

Low

1273220

TM263
Transmembrane protein 263

1

0

High-throughput

0.279

Low

640201

EPHA1
Ephrin type-A receptor 1

1

0

High-throughput

0.261

Low

459306

CATL1
Procathepsin L

1

0

High-throughput

0.249

Low

1031431

IFM3
Interferon-induced transmembrane protein 3

1

0

High-throughput

0.249

Low

1213385

CFA58
Cilia- and flagella-associated protein 58

1

0

High-throughput

0.249

Low

1273228

ACE2
Angiotensin-converting enzyme 2

1

0

High-throughput

0.249

Low

139253

UPK2
Uroplakin-2

1

0

High-throughput

0.232

Low

1273225

OPALI
Opalin

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025