HitPredict

Interactor 1: TNR5 (P25942)
Tumor necrosis factor receptor superfamily member 5 (B-cell surface antigen CD40) (Bp50) (CD40L receptor) (CDw40) (CD antigen CD40)
Gene: CD40

Interactor 2: TRAF6 (Q9Y4K3)
TNF receptor-associated factor 6 (EC 2.3.2.27) (E3 ubiquitin-protein ligase TRAF6) (Interleukin-1 signal transducer) (RING finger protein 85) (RING-type E3 ubiquitin transferase TRAF6)
Gene: TRAF6

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.96 0.60 0.761

The method score is based on:

Property Details
Experiments 12140561, 12220533, 20614026, 24812060, 9990007, 9384571, 16260598, 9718306, 21041727, 12637493, 20449947, 20676093, 10748240, 17332487
Identification Methods x-ray crystallography, affinity chromatography technology, pull down, fluorescent resonance energy transfer, anti tag coimmunoprecipitation
Interaction Type association, physical association, direct interaction

The annotation score is based on:

Property Details
Interacting Pfam domains -
Common GO terms GO:0005886 - plasma membrane
GO:0032735 - positive regulation of interleukin-12 production
GO:0035631 - CD40 receptor complex
GO:0035666 - TRIF-dependent toll-like receptor signaling pathway
GO:0043123 - positive regulation of canonical NF-kappaB signal transduction
and 3 others

more...
Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

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Service provided by Combinatics, Japan

Last updated: 15 Jul 2024