HitPredict

Interactor 1: DNMT1 (P26358)
DNA (cytosine-5)-methyltransferase 1 (Dnmt1) (EC 2.1.1.37) (CXXC-type zinc finger protein 9) (DNA methyltransferase HsaI) (DNA MTase HsaI) (M.HsaI) (MCMT)
Gene: DNMT1

Interactor 2: HDAC2 (Q92769)
Histone deacetylase 2 (HD2) (EC 3.5.1.98) (Protein deacylase HDAC2) (EC 3.5.1.-)
Gene: HDAC2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.79	0.60	0.692

Property	Details
Experiments	10888872, 21670149, 23708667, 17967891
Identification Methods	two hybrid, affinity chromatography technology, pull down
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0003723 - RNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:1990841 - promoter-specific chromatin binding
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 1616 Hs			1 488
+	Hs
		641212 DNMT1_HUMAN (1-1616): 0: 1717: 100.00		HDAC1_HUMAN (1-443): 0: 642: 90.07
+	Hs
		177200 DNMT1_HUMAN (1-1616): 0: 1717: 100.00		HDAC3_HUMAN (10-431): 0: 574: 58.26
+	Mm
		140219 DNMT1_MOUSE (1-1597): 0: 1615: 77.33		HDAC1_MOUSE (1-443): 0: 645: 90.29
+	Xl
		945575 P79922_XENLA (126-1616): 0: 1502: 70.07		Q7ZYT5_XENLA (1-486): 0: 678: 87.04
+	Xl
		945595 P79922_XENLA (126-1616): 0: 1502: 70.07		HDA1A_XENLA (1-486): 0: 631: 83.95
+	Mm
		533910 DNMT1_MOUSE (1-1597): 0: 1615: 77.33		HDAC4_MOUSE (1-377): 6.12e-133: 412: 23.89
+	At
		713424 DNMT1_ARATH (263-1604): 0: 964: 29.28		HDA6_ARATH (1-467): 0: 578: 57.02
+	Mm
		1157725 PB1_MOUSE (42-1162): 0: 606: 15.20		HDAC4_MOUSE (1-377): 6.12e-133: 412: 23.89
+	Mm
		101536 F8VQD1_MOUSE (42-1162): 0: 600: 14.69		HDAC4_MOUSE (1-377): 6.12e-133: 412: 23.89
+	Hs
		1270494 DNM3B_HUMAN (1130-1325): 2.44e-41: 167: 17.65		HDAC2_HUMAN (1-488): 0: 707: 100.00
+	Hs
		1270533 SMC3_HUMAN (112-523): 4.15e-40: 164: 12.53		HDAC2_HUMAN (1-488): 0: 707: 100.00
+	Rn
		100231 Q1LZ51_RAT (1124-1325): 3.84e-40: 163: 18.52		F7ENH8_RAT (1-488): 0: 706: 98.98
+	Hs
		1038774 DNM3B_HUMAN (1130-1325): 2.44e-41: 167: 17.65		HDAC1_HUMAN (1-443): 0: 642: 90.07
+	Hs
		1038858 DNM3A_HUMAN (1128-1326): 1.35e-36: 152: 17.87		HDAC1_HUMAN (1-443): 0: 642: 90.07
+	Hs
		1038652 MINT_HUMAN (5-706): 1.98e-35: 150: 12.71		HDAC1_HUMAN (1-443): 0: 642: 90.07
+	Hs
		1316068 SMC3_HUMAN (112-523): 4.15e-40: 164: 12.53		HDAC8_HUMAN (33-372): 1.01e-137: 403: 43.40