HitPredict

Interactor 1: ERBB3 (P21860)
Receptor tyrosine-protein kinase erbB-3 (EC 2.7.10.1) (Proto-oncogene-like protein c-ErbB-3) (Tyrosine kinase-type cell surface receptor HER3)
Gene: ERBB3

Interactor 2: PPM1K (Q8N3J5)
Protein phosphatase Mn(2+)-dependent 1K (EC 3.1.3.16) (Branched-chain alpha-ketoacid dehydrogenase phosphatase) (BCKDH) (BDP) (EC 3.1.3.52) (PP2C domain-containing protein phosphatase 1K) (PP2C-like mitochondrial protein) (PP2C-type mitochondrial phosphoprotein phosphatase) (PTMP) (Protein phosphatase 2C family member) (Protein phosphatase 2C isoform kappa) (PP2C-kappa) ([3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring)]-phosphatase, mitochondrial)
Gene: PPM1K

Species: Homo sapiens

Source: mint

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.48	0.50	0.494

Property	Details
Experiments	28065597
Identification Methods	two hybrid, ubiquitin reconstruction
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1342 Hs			1 372
+	Hs
		641502 ERBB3_HUMAN (1-1342): 0: 1390: 100.00		PPM1A_HUMAN (72-362): 4.25e-103: 310: 27.94
+	Hs
		290856 ERBB3_HUMAN (1-1342): 0: 1390: 100.00		PPM1B_HUMAN (72-362): 1.82e-98: 302: 27.19
+	Hs
		641671 ERBB3_HUMAN (1-1342): 0: 1390: 100.00		ILKAP_HUMAN (114-347): 8.99e-27: 111: 32.06
+	Hs
		776959 ERBB4_HUMAN (1-1162): 0: 1154: 50.94		PPM1A_HUMAN (72-362): 4.25e-103: 310: 27.94
+	Hs
		290934 ERBB4_HUMAN (1-1162): 0: 1154: 50.94		PPM1B_HUMAN (72-362): 1.82e-98: 302: 27.19
+	Hs
		410669 ERBB2_HUMAN (25-1222): 0: 1075: 39.95		PPM1A_HUMAN (72-362): 4.25e-103: 310: 27.94
+	Hs
		362882 EGFR_HUMAN (18-1211): 0: 1060: 40.65		PPM1A_HUMAN (72-362): 4.25e-103: 310: 27.94
+	Hs
		290823 EGFR_HUMAN (18-1211): 0: 1060: 40.65		PPM1B_HUMAN (72-362): 1.82e-98: 302: 27.19
+	Hs
		1145776 ERBB4_HUMAN (1-1162): 0: 1154: 50.94		ILKAP_HUMAN (114-347): 8.99e-27: 111: 32.06
+	Hs
		411043 ERBB2_HUMAN (25-1222): 0: 1075: 39.95		ILKAP_HUMAN (114-347): 8.99e-27: 111: 32.06
+	Hs
		363834 EGFR_HUMAN (18-1211): 0: 1060: 40.65		ILKAP_HUMAN (114-347): 8.99e-27: 111: 32.06
+	At
		1342068 WAK3_ARATH (327-986): 8.74e-132: 425: 15.60		P2C02_ARATH (26-348): 9.04e-97: 294: 26.92
+	Hs
		290919 ROR1_HUMAN (490-1147): 1.52e-125: 414: 17.37		PPM1B_HUMAN (72-362): 1.82e-98: 302: 27.19
+	Hs
		776948 ROR2_HUMAN (491-1088): 8.52e-118: 393: 20.22		PPM1A_HUMAN (72-362): 4.25e-103: 310: 27.94
+	Hs
		290920 ROR2_HUMAN (491-1088): 8.52e-118: 393: 20.22		PPM1B_HUMAN (72-362): 1.82e-98: 302: 27.19
+	Hs
		710100 EPHA2_HUMAN (665-996): 2e-104: 357: 29.40		PPM1A_HUMAN (72-362): 4.25e-103: 310: 27.94
+	Hs
		710284 EPHA2_HUMAN (665-996): 2e-104: 357: 29.40		PPM1L_HUMAN (94-355): 3.81e-92: 282: 31.88
+	Hs
		1034190 ROR1_HUMAN (490-1147): 1.52e-125: 414: 17.37		ILKAP_HUMAN (114-347): 8.99e-27: 111: 32.06
+	Hs
		1034337 ROR2_HUMAN (491-1088): 8.52e-118: 393: 20.22		ILKAP_HUMAN (114-347): 8.99e-27: 111: 32.06
+	Hs
		710475 EPHA2_HUMAN (665-996): 2e-104: 357: 29.40		ILKAP_HUMAN (114-347): 8.99e-27: 111: 32.06