HitPredict

Interactor 1: CLH (P22137)
Clathrin heavy chain
Gene: CHC1

Interactor 2: ENT5 (Q03769)
Epsin-5
Gene: ENT5

Species: Saccharomyces cerevisiae S288C

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.79	0.60	0.689

Property	Details
Experiments	26842894, 16687571, 17344475, 39511183
Identification Methods	affinity chromatography technology, x-ray crystallography, pull down
Interaction Type	physical association, association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0006895 - Golgi to endosome transport GO:0006897 - endocytosis GO:0030125 - clathrin vesicle coat
Homologous interactions	11

Homologous interactions

Color coding for hit scores

	1 1653 Sc			1 411
+	Hs
		1026305 CLH1_HUMAN (4-1648): 0: 2877: 49.76		EPN1_HUMAN (19-409): 1.56e-107: 330: 19.55
+	Rn
		312071 CLH1_RAT (4-1648): 0: 2869: 49.76		EPN1_RAT (19-409): 1.15e-103: 320: 19.05
+	Hs
		1026033 CLH1_HUMAN (4-1648): 0: 2877: 49.76		EPN4_HUMAN (11-402): 3.43e-88: 281: 16.24
+	Hs
		329445 CLH1_HUMAN (4-1648): 0: 2877: 49.76		EPN2_HUMAN (19-409): 9.79e-86: 275: 14.10
+	Dm
		715112 CLH_DROME (4-1650): 0: 2790: 48.58		Q7KU90_DROME (15-408): 1.72e-82: 271: 16.79
+	Hs
		922433 CLH2_HUMAN (4-1635): 0: 2756: 48.90		EPN4_HUMAN (11-402): 3.43e-88: 281: 16.24
+	At
		1081872 CLAH2_ARATH (2-1635): 0: 2637: 43.64		EPN2_ARATH (16-402): 3.33e-67: 231: 15.57
+	At
		1081950 CLAH1_ARATH (2-1642): 0: 2625: 43.39		EPN1_ARATH (16-411): 6.56e-71: 234: 18.36
+	Sc
		644807 CLH_YEAST (1-1653): 0: 2505: 100.00		ENT3_YEAST (3-406): 1.86e-78: 249: 16.47
+	Sc
		644862 CLH_YEAST (1-1653): 0: 2505: 100.00		ENT1_YEAST (17-248): 5.99e-51: 179: 20.17
+	Sc
		644841 CLH_YEAST (1-1653): 0: 2505: 100.00		ENT2_YEAST (17-240): 6.52e-46: 169: 19.31