Protein: EPN1
Epsin-1 (EH domain-binding mitotic phosphoprotein) (EPS-15-interacting protein 1)

Gene: EPN1
Organism: Homo sapiens
Interactions: 118
UniProt ID: Q9Y6I3

Gene Ontology (top 5):
GO:0001701 - in utero embryonic development
GO:0005543 - phospholipid binding
GO:0005634 - nucleus
GO:0005768 - endosome
GO:0005829 - cytosol

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1431394

EPN3
Epsin-3

3

12

High-throughput

0.861

High

508924

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

7

17

Small-scale

0.747

High

839851

EPS15
Epidermal growth factor receptor substrate 15

7

20

Small-scale

0.745

High

1339269

REPS2
RalBP1-associated Eps domain-containing protein 2

4

20

Small-scale

0.700

High

209706

SERA
D-3-phosphoglycerate dehydrogenase

4

2

High-throughput

0.699

High

1139170

DAZP2
DAZ-associated protein 2

3

3

High-throughput

0.675

High

1327853

ARRD1
Arrestin domain-containing protein 1

3

5

High-throughput

0.667

High

1386762

AP2M1
AP-2 complex subunit mu

3

5

High-throughput

0.667

High

271757

HIP1R
Huntingtin-interacting protein 1-related protein

1

4

Small-scale

0.647

High

364103

EGFR
Epidermal growth factor receptor

3

11

Small-scale

0.640

High

1287342

TAD2B
Transcriptional adapter 2-beta

3

0

High-throughput

0.638

High

1392027

PLPR2
Phospholipid phosphatase-related protein type 2

3

0

High-throughput

0.638

High

1491845

EPN1
Epsin-1

1

9

High-throughput

0.618

High

483285

CLCA
Clathrin light chain A

2

8

High-throughput

0.611

High

1026305

CLH1
Clathrin heavy chain 1

2

12

Small-scale

0.611

High

181031

LRAD4
Low-density lipoprotein receptor class A domain-containing protein 4

3

1

High-throughput

0.609

High

1328460

S2541
Mitochondrial carrier protein SCaMC-3L

3

1

High-throughput

0.609

High

1405000

GA2L1
GAS2-like protein 1

3

2

High-throughput

0.609

High

1406915

LITAF
Lipopolysaccharide-induced tumor necrosis factor-alpha factor

2

4

High-throughput

0.606

High

1350962

GTR14
Solute carrier family 2, facilitated glucose transporter member 14

2

0

High-throughput

0.602

High

1107646

PICAL
Phosphatidylinositol-binding clathrin assembly protein

1

11

High-throughput

0.590

High

1462466

FLVC2
Choline/ethanolamine transporter FLVCR2

2

0

High-throughput

0.585

High

1145938

RBP1
RalA-binding protein 1

2

4

Small-scale

0.584

High

1459908

UBQL2
Ubiquilin-2

2

8

Small-scale

0.584

High

619974

VCAM1
Vascular cell adhesion protein 1

2

0

High-throughput

0.576

High

397343

ESR1
Estrogen receptor

2

15

High-throughput

0.571

High

431623

AP2A
Transcription factor AP-2-alpha

2

0

Small-scale

0.569

High

323809

AP2A2
AP-2 complex subunit alpha-2

1

20

Small-scale

0.561

High

788558

SCNNA
Epithelial sodium channel subunit alpha

1

2

Small-scale

0.561

High

902330

SCNNB
Epithelial sodium channel subunit beta

1

2

Small-scale

0.561

High

902343

SCNNG
Epithelial sodium channel subunit gamma

1

2

Small-scale

0.561

High

331452

KI20A
Kinesin-like protein KIF20A

1

6

High-throughput

0.536

High

487942

PARP1
Poly [ADP-ribose] polymerase 1

1

5

High-throughput

0.536

High

502191

H2AZ
Histone H2A.Z

1

4

High-throughput

0.536

High

540784

LAMP1
Lysosome-associated membrane glycoprotein 1

1

6

High-throughput

0.536

High

625734

CSK22
Casein kinase II subunit alpha'

1

3

High-throughput

0.536

High

638565

FPR1
fMet-Leu-Phe receptor

1

2

High-throughput

0.536

High

698399

MAP4
Microtubule-associated protein 4

1

11

High-throughput

0.536

High

957049

CXCR4
C-X-C chemokine receptor type 4

1

2

High-throughput

0.536

High

980631

H4
Histone H4

1

1

High-throughput

0.536

High

987285

RS27A
Ubiquitin-ribosomal protein eS31 fusion protein

1

12

High-throughput

0.536

High

1116181

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1

5

High-throughput

0.536

High

1232749

H2A2A
Histone H2A type 2-A

1

3

High-throughput

0.536

High

1363662

H1X
Histone H1.10

1

1

High-throughput

0.536

High

1429561

RB33B
Ras-related protein Rab-33B

1

1

High-throughput

0.536

High

1452905

GTSE1
G2 and S phase-expressed protein 1

1

4

High-throughput

0.536

High

1452934

TECR
Very-long-chain enoyl-CoA reductase

1

1

High-throughput

0.536

High

1491505

MB212
Protein mab-21-like 2

1

1

High-throughput

0.536

High

1386469

PKHB2
Pleckstrin homology domain-containing family B member 2

1

1

High-throughput

0.523

High

1123246

DPYL1
Dihydropyrimidinase-related protein 1

1

0

High-throughput

0.518

High

1491185

MED31
Mediator of RNA polymerase II transcription subunit 31

1

0

High-throughput

0.518

High

212357

SNUT1
U4/U6.U5 tri-snRNP-associated protein 1

1

0

High-throughput

0.513

High

347445

BAG2
BAG family molecular chaperone regulator 2

1

0

High-throughput

0.513

High

389589

FINC
Fibronectin

1

0

High-throughput

0.513

High

445296

S10A6
Protein S100-A6

1

0

High-throughput

0.513

High

1110945

LAPM5
Lysosomal-associated transmembrane protein 5

1

1

High-throughput

0.508

High

1491178

RNF11
RING finger protein 11

1

2

High-throughput

0.508

High

1155214

EREP1
Endosomal transmembrane epsin interactor 1

1

2

Small-scale

0.506

High

443574

CDK1
Cyclin-dependent kinase 1

1

1

Small-scale

0.501

High

1439029

SMUF1
E3 ubiquitin-protein ligase SMURF1

1

4

Small-scale

0.501

High

755522

ERD22
ER lumen protein-retaining receptor 2

1

2

High-throughput

0.489

High

1010557

EREP3
Protein ENTREP3

1

2

High-throughput

0.489

High

1418967

WNK3
Serine/threonine-protein kinase WNK3

1

1

High-throughput

0.489

High

1436418

PAAT
ATPase PAAT

1

3

High-throughput

0.489

High

1098873

M3K1
Mitogen-activated protein kinase kinase kinase 1

1

0

Small-scale

0.480

High

1349793

FBX25
F-box only protein 25

1

0

Small-scale

0.480

High

139663

DLL1
Delta-like protein 1

1

1

Small-scale

0.479

High

159939

DVL2
Segment polarity protein dishevelled homolog DVL-2

1

4

Small-scale

0.479

High

173625

XPO1
Exportin-1

1

7

High-throughput

0.479

High

219035

TGON2
Trans-Golgi network integral membrane protein 2

1

6

High-throughput

0.479

High

270493

FZD7
Frizzled-7

1

1

Small-scale

0.479

High

344839

AP2A1
AP-2 complex subunit alpha-1

1

20

Small-scale

0.479

High

376159

RASK
GTPase KRas

1

10

High-throughput

0.479

High

412907

NTRK1
High affinity nerve growth factor receptor

1

14

High-throughput

0.479

High

464092

RET
Proto-oncogene tyrosine-protein kinase receptor Ret

1

20

High-throughput

0.479

High

483424

CLCB
Clathrin light chain B

1

8

High-throughput

0.479

High

541789

FGFR1
Fibroblast growth factor receptor 1

1

19

High-throughput

0.479

High

560573

IFM1
Interferon-induced transmembrane protein 1

1

1

High-throughput

0.479

High

565504

ITA4
Integrin alpha-4

1

1

High-throughput

0.479

High

641719

ERBB3
Receptor tyrosine-protein kinase erbB-3

1

10

Small-scale

0.479

High

777811

VGFR3
Vascular endothelial growth factor receptor 3

1

15

Small-scale

0.479

High

778121

VGFR2
Vascular endothelial growth factor receptor 2

1

11

Small-scale

0.479

High

857608

NOTC1
Neurogenic locus notch homolog protein 1

1

2

Small-scale

0.479

High

946944

H2B1D
Histone H2B type 1-D

1

15

High-throughput

0.479

High

978438

RHOB
Rho-related GTP-binding protein RhoB

1

10

High-throughput

0.479

High

989181

AP2B1
AP-2 complex subunit beta

1

20

High-throughput

0.479

High

1031628

IFM3
Interferon-induced transmembrane protein 3

1

1

High-throughput

0.479

High

1033959

SC6A3
Sodium-dependent dopamine transporter

1

1

Small-scale

0.479

High

1083341

AP1B1
AP-1 complex subunit beta-1

1

20

Small-scale

0.479

High

1108335

SQSTM
Sequestosome-1

1

4

High-throughput

0.479

High

1159929

OCLN
Occludin

1

1

Small-scale

0.479

High

1233623

LTOR1
Ragulator complex protein LAMTOR1

1

3

High-throughput

0.479

High

1399273

ANR27
Ankyrin repeat domain-containing protein 27

1

3

High-throughput

0.479

High

1433159

FZD8
Frizzled-8

1

1

Small-scale

0.479

High

1434401

EHD1
EH domain-containing protein 1

1

20

Small-scale

0.479

High

1453486

EHD2
EH domain-containing protein 2

1

19

Small-scale

0.479

High

1458294

EP15R
Epidermal growth factor receptor substrate 15-like 1

1

20

Small-scale

0.479

High

1462798

LAMP3
Lysosome-associated membrane glycoprotein 3

1

6

High-throughput

0.479

High

1491409

IRS2
Insulin receptor substrate 2

1

5

Small-scale

0.479

High

1491846

AP1M2
AP-1 complex subunit mu-2

1

5

Small-scale

0.479

High

287637

LRP6
Low-density lipoprotein receptor-related protein 6

1

0

Small-scale

0.458

High

390833

TFR1
Transferrin receptor protein 1

1

0

High-throughput

0.458

High

699910

P85A
Phosphatidylinositol 3-kinase regulatory subunit alpha

1

0

Small-scale

0.458

High

1366380

TF3A
Transcription factor IIIA

1

0

Small-scale

0.458

High

942992

BCAR1
Breast cancer anti-estrogen resistance protein 1

1

7

High-throughput

0.445

High

1235054

PKHA7
Pleckstrin homology domain-containing family A member 7

1

10

High-throughput

0.445

High

1491847

U3KQK0
Histone H2B

1

15

High-throughput

0.445

High

106940

APRIO
Alternative prion protein

1

5

High-throughput

0.437

High

1256314

TRI67
Tripartite motif-containing protein 67

1

12

High-throughput

0.437

High

1293229

TMM17
Transmembrane protein 17

1

2

High-throughput

0.437

High

1454879

B3GA1
Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 1

1

1

High-throughput

0.437

High

1326186

RYBP
RING1 and YY1-binding protein

1

0

High-throughput

0.426

High

1454605

CE126
Centrosomal protein of 126 kDa

1

0

High-throughput

0.282

High

292265

S2512
Electrogenic aspartate/glutamate antiporter SLC25A12, mitochondrial

1

0

High-throughput

0.279

Low

1383969

TM45B
Transmembrane protein 45B

1

0

High-throughput

0.279

Low

1358048

TM171
Transmembrane protein 171

1

0

High-throughput

0.232

Low

1398033

MF14A
Hippocampus abundant transcript 1 protein

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025