HitPredict

Interactor 1: CLH (P22137)
Clathrin heavy chain
Gene: CHC1

Interactor 2: ENT1 (Q12518)
Epsin-1
Gene: ENT1

Species: Saccharomyces cerevisiae S288C

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.85	0.60	0.718

Property	Details
Experiments	32400111, 39511183, 14704157, 10449404, 12529323
Identification Methods	fluorescent resonance energy transfer, x-ray crystallography, pull down, affinity chromatography technology
Interaction Type	direct interaction, association, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0006897 - endocytosis GO:0030125 - clathrin vesicle coat
Homologous interactions	12

Homologous interactions

Color coding for hit scores

	1 1653 Sc			1 454
+	Hs
		1026305 CLH1_HUMAN (4-1648): 0: 2877: 49.76		EPN1_HUMAN (2-454): 2.23e-107: 331: 21.10
+	Hs
		1026033 CLH1_HUMAN (4-1648): 0: 2877: 49.76		EPN4_HUMAN (3-442): 1.21e-104: 325: 18.93
+	Rn
		312071 CLH1_RAT (4-1648): 0: 2869: 49.76		EPN1_RAT (2-454): 5.14e-108: 332: 20.69
+	Hs
		329445 CLH1_HUMAN (4-1648): 0: 2877: 49.76		EPN2_HUMAN (2-426): 2.31e-101: 317: 22.87
+	Dm
		715112 CLH_DROME (4-1650): 0: 2790: 48.58		Q7KU90_DROME (5-446): 5.02e-91: 295: 25.71
+	Hs
		922433 CLH2_HUMAN (4-1635): 0: 2756: 48.90		EPN4_HUMAN (3-442): 1.21e-104: 325: 18.93
+	Bt
		892762 CLH1_BOVIN (4-1648): 0: 2877: 49.76		AUXI_BOVIN (134-454): 1.68e-11: 68.7: 10.73
+	At
		1081950 CLAH1_ARATH (2-1642): 0: 2625: 43.39		EPN1_ARATH (3-454): 2.5e-96: 302: 17.34
+	At
		1081872 CLAH2_ARATH (2-1635): 0: 2637: 43.64		EPN2_ARATH (3-439): 4.65e-82: 272: 19.92
+	Sc
		644807 CLH_YEAST (1-1653): 0: 2505: 100.00		ENT3_YEAST (2-382): 9.02e-88: 275: 19.80
+	Sc
		644831 CLH_YEAST (1-1653): 0: 2505: 100.00		ENT5_YEAST (3-352): 1.37e-62: 210: 13.92
+	Sc
		644841 CLH_YEAST (1-1653): 0: 2505: 100.00		ENT2_YEAST (340-447): 1.08e-16: 84.5: 75.00