Protein: EPN2
Epsin-2 (EPS-15-interacting protein 2)

Gene: EPN2
Organism: Homo sapiens
Interactions: 94
UniProt ID: O95208

Gene Ontology (top 5):
GO:0005543 - phospholipid binding
GO:0005768 - endosome
GO:0005829 - cytosol
GO:0005886 - plasma membrane
GO:0006897 - endocytosis

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

329485

EPN3
Epsin-3

3

14

High-throughput

0.861

High

329418

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

6

18

Small-scale

0.735

High

329424

1433T
14-3-3 protein theta

4

20

High-throughput

0.678

High

329427

EPHA2
Ephrin type-A receptor 2

3

7

High-throughput

0.656

High

329444

1433Z
14-3-3 protein zeta/delta

3

20

High-throughput

0.650

High

329428

1433B
14-3-3 protein beta/alpha

3

20

High-throughput

0.643

High

329474

WBP2
WW domain-binding protein 2

3

0

Small-scale

0.626

High

329441

RS27A
Ubiquitin-ribosomal protein eS31 fusion protein

2

13

High-throughput

0.614

High

329415

CLCA
Clathrin light chain A

2

10

High-throughput

0.611

High

186492

TRI18
E3 ubiquitin-protein ligase Midline-1

2

11

High-throughput

0.606

High

302286

RNF8
E3 ubiquitin-protein ligase RNF8

2

6

High-throughput

0.606

High

329429

TRI23
E3 ubiquitin-protein ligase TRIM23

2

6

High-throughput

0.606

High

329432

TXLNA
Alpha-taxilin

2

5

High-throughput

0.606

High

329442

RL40
Ubiquitin-ribosomal protein eL40 fusion protein

2

9

High-throughput

0.606

High

329447

TRI26
Tripartite motif-containing protein 26

2

4

High-throughput

0.606

High

329452

SMAD1
Mothers against decapentaplegic homolog 1

2

3

High-throughput

0.606

High

329463

FANCM
Fanconi anemia group M protein

2

4

High-throughput

0.606

High

329464

SPART
Spartin

2

3

High-throughput

0.606

High

329467

ARRD1
Arrestin domain-containing protein 1

2

5

High-throughput

0.606

High

329468

ARRD2
Arrestin domain-containing protein 2

2

5

High-throughput

0.606

High

329475

PMEPA
Protein TMEPAI

2

1

High-throughput

0.606

High

329476

ARRD3
Arrestin domain-containing protein 3

2

5

High-throughput

0.606

High

329481

LITAF
Lipopolysaccharide-induced tumor necrosis factor-alpha factor

2

4

High-throughput

0.606

High

329482

TRI62
E3 ubiquitin-protein ligase TRIM62

2

4

High-throughput

0.606

High

329439

1433G
14-3-3 protein gamma

2

20

High-throughput

0.601

High

329446

1433F
14-3-3 protein eta

2

20

High-throughput

0.601

High

329448

PICAL
Phosphatidylinositol-binding clathrin assembly protein

1

12

High-throughput

0.590

High

329440

RHOB
Rho-related GTP-binding protein RhoB

2

12

High-throughput

0.584

High

329434

THOP1
Thimet oligopeptidase

2

0

High-throughput

0.580

High

329435

ATX1
Ataxin-1

2

0

High-throughput

0.580

High

329436

AAPK2
5'-AMP-activated protein kinase catalytic subunit alpha-2

2

0

High-throughput

0.580

High

329438

EIF3E
Eukaryotic translation initiation factor 3 subunit E

2

0

High-throughput

0.580

High

329455

MAR1
Melanoma antigen recognized by T-cells 1

2

0

High-throughput

0.580

High

329461

PP4P1
Type 1 phosphatidylinositol 4,5-bisphosphate 4-phosphatase

2

0

High-throughput

0.580

High

329413

ESR1
Estrogen receptor

2

17

High-throughput

0.571

High

329450

DAZP2
DAZ-associated protein 2

2

3

High-throughput

0.553

High

329471

F168A
Protein FAM168A

2

2

High-throughput

0.553

High

329477

PKHB2
Pleckstrin homology domain-containing family B member 2

2

1

High-throughput

0.553

High

329478

WBP1
WW domain-binding protein 1

2

1

High-throughput

0.553

High

329486

CDIP1
Cell death-inducing p53-target protein 1

2

4

High-throughput

0.553

High

329488

WBP1L
WW domain binding protein 1-like

2

1

High-throughput

0.553

High

329491

TRIM1
Probable E3 ubiquitin-protein ligase MID2

2

11

High-throughput

0.553

High

329417

PARP1
Poly [ADP-ribose] polymerase 1

1

7

High-throughput

0.536

High

329426

SMCA1
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 1

1

3

High-throughput

0.536

High

329470

H1X
Histone H1.10

1

1

High-throughput

0.536

High

329489

GTSE1
G2 and S phase-expressed protein 1

1

3

High-throughput

0.536

High

329445

CLH1
Clathrin heavy chain 1

1

15

Small-scale

0.501

High

329479

SYGP1
Ras/Rap GTPase-activating protein SynGAP

1

5

High-throughput

0.500

High

47937

RBM47
RNA-binding protein 47

1

3

High-throughput

0.489

High

329408

NSD2
Histone-lysine N-methyltransferase NSD2

1

6

High-throughput

0.489

High

329456

H2A2A
Histone H2A type 2-A

1

4

High-throughput

0.489

High

329473

RAD50
DNA repair protein RAD50

1

6

High-throughput

0.489

High

329412

APOE
Apolipoprotein E

1

1

High-throughput

0.481

High

329430

SYUA
Alpha-synuclein

1

1

High-throughput

0.481

High

329453

ITSN1
Intersectin-1

1

16

High-throughput

0.481

High

189357

STX7
Syntaxin-7

1

5

High-throughput

0.479

High

217651

TGON2
Trans-Golgi network integral membrane protein 2

1

4

High-throughput

0.479

High

225895

STX6
Syntaxin-6

1

4

High-throughput

0.479

High

329407

DIRA3
GTP-binding protein Di-Ras3

1

3

High-throughput

0.479

High

329409

EGFR
Epidermal growth factor receptor

1

8

High-throughput

0.479

High

329410

RASH
GTPase HRas

1

9

High-throughput

0.479

High

329411

RASK
GTPase KRas

1

10

High-throughput

0.479

High

329416

CLCB
Clathrin light chain B

1

10

High-throughput

0.479

High

329419

LAMP1
Lysosome-associated membrane glycoprotein 1

1

5

High-throughput

0.479

High

329420

FGFR1
Fibroblast growth factor receptor 1

1

20

High-throughput

0.479

High

329421

CADH1
Cadherin-1

1

3

High-throughput

0.479

High

329422

CXA1
Gap junction alpha-1 protein

1

3

High-throughput

0.479

High

329423

FGFR4
Fibroblast growth factor receptor 4

1

20

High-throughput

0.479

High

329433

OPRD
Delta-type opioid receptor

1

2

Small-scale

0.479

High

329437

H2B1D
Histone H2B type 1-D

1

20

High-throughput

0.479

High

329443

AP2B1
AP-2 complex subunit beta

1

20

High-throughput

0.479

High

329451

RBP1
RalA-binding protein 1

1

5

Small-scale

0.479

High

329457

LTOR1
Ragulator complex protein LAMTOR1

1

3

High-throughput

0.479

High

329460

ATG9A
Autophagy-related protein 9A

1

3

High-throughput

0.479

High

329465

CXD3
Gap junction delta-3 protein

1

3

High-throughput

0.479

High

329466

RHG18
Rho GTPase-activating protein 18

1

3

High-throughput

0.479

High

329469

SMAP2
Stromal membrane-associated protein 2

1

3

High-throughput

0.479

High

329472

ESR2
Estrogen receptor beta

1

16

High-throughput

0.479

High

329487

BACD3
BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 3

1

7

Small-scale

0.479

High

329490

UBQL2
Ubiquilin-2

1

8

Small-scale

0.479

High

329492

MYO6
Unconventional myosin-VI

1

4

High-throughput

0.479

High

329414

G3P
Glyceraldehyde-3-phosphate dehydrogenase

1

0

High-throughput

0.458

High

329425

DPP4
Dipeptidyl peptidase 4

1

0

High-throughput

0.458

High

329480

RAB3I
Rab-3A-interacting protein

1

0

High-throughput

0.458

High

329484

ACE2
Angiotensin-converting enzyme 2

1

0

High-throughput

0.458

High

329454

EREP1
Endosomal transmembrane epsin interactor 1

1

2

Small-scale

0.457

High

105007

APRIO
Alternative prion protein

1

6

High-throughput

0.437

High

329431

HSPA9
Stress-70 protein, mitochondrial

1

3

High-throughput

0.437

High

329449

SART3
Spliceosome associated factor 3, U4/U6 recycling protein

1

1

High-throughput

0.437

High

329458

TRI67
Tripartite motif-containing protein 67

1

12

High-throughput

0.437

High

329462

TMM17
Transmembrane protein 17

1

2

High-throughput

0.437

High

329483

LFG2
Protein lifeguard 2

2

0

High-throughput

0.316

High

139790

RCAS1
Receptor-binding cancer antigen expressed on SiSo cells

1

0

High-throughput

0.249

Low

329459

CR3L2
Cyclic AMP-responsive element-binding protein 3-like protein 2

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025