HitPredict

Interactor 1: FGFR4 (P22455)
Fibroblast growth factor receptor 4 (FGFR-4) (EC 2.7.10.1) (CD antigen CD334)
Gene: FGFR4

Interactor 2: MERL (P35240)
Merlin (Moesin-ezrin-radixin-like protein) (Neurofibromin-2) (Schwannomerlin) (Schwannomin)
Gene: NF2

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.58	1.00	0.768

Property	Details
Experiments	28205554, 35384245
Identification Methods	fluorescent resonance energy transfer, proximity labelling technology
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	FERM_M~PK_Tyr_Ser-Thr
Common GO terms	GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 802 Hs			1 595
+	Hs
		541368 FGFR1_HUMAN (3-794): 0: 714: 54.76		MERL_HUMAN (1-595): 1.13e-172: 504: 100.00
+	Hs
		582664 FGFR4_HUMAN (13-802): 0: 755: 100.00		EZRI_HUMAN (19-595): 8.25e-152: 450: 44.20
+	Hs
		648442 FGFR4_HUMAN (13-802): 0: 755: 100.00		RADI_HUMAN (19-595): 5.43e-151: 448: 45.47
+	Hs
		648424 FGFR4_HUMAN (13-802): 0: 755: 100.00		MOES_HUMAN (19-595): 6e-146: 435: 44.44
+	Hs
		650068 FGFR3_HUMAN (5-799): 0: 720: 61.07		RADI_HUMAN (19-595): 5.43e-151: 448: 45.47
+	Hs
		541312 FGFR1_HUMAN (3-794): 0: 714: 54.76		EZRI_HUMAN (19-595): 8.25e-152: 450: 44.20
+	Hs
		541369 FGFR1_HUMAN (3-794): 0: 714: 54.76		RADI_HUMAN (19-595): 5.43e-151: 448: 45.47
+	Hs
		541349 FGFR1_HUMAN (3-794): 0: 714: 54.76		MOES_HUMAN (19-595): 6e-146: 435: 44.44
+	Hs
		538874 FGFR3_HUMAN (5-799): 0: 720: 61.07		EPB41_HUMAN (3-566): 9.76e-126: 392: 19.73
+	Hs
		710785 EPHB2_HUMAN (61-781): 0: 589: 18.54		MERL_HUMAN (1-595): 1.13e-172: 504: 100.00
+	Hs
		710096 EPHA2_HUMAN (4-789): 0: 587: 19.52		MERL_HUMAN (1-595): 1.13e-172: 504: 100.00
+	Hs
		541699 FGFR1_HUMAN (3-794): 0: 714: 54.76		E41LA_HUMAN (19-416): 3.98e-121: 375: 24.46
+	Hs
		320534 FGFR3_HUMAN (5-799): 0: 720: 61.07		FARP2_HUMAN (3-537): 6.44e-112: 360: 17.89
+	Hs
		541777 FGFR1_HUMAN (3-794): 0: 714: 54.76		FARP1_HUMAN (2-526): 5.4e-114: 366: 18.35
+	Hs
		767409 EPHA5_HUMAN (4-771): 0: 615: 18.43		RADI_HUMAN (19-595): 5.43e-151: 448: 45.47
+	Hs
		582679 EPHA2_HUMAN (4-789): 0: 587: 19.52		EZRI_HUMAN (19-595): 8.25e-152: 450: 44.20
+	Hs
		710786 EPHB2_HUMAN (61-781): 0: 589: 18.54		RADI_HUMAN (19-595): 5.43e-151: 448: 45.47
+	Hs
		683779 EPHB2_HUMAN (61-781): 0: 589: 18.54		MOES_HUMAN (19-595): 6e-146: 435: 44.44
+	Hs
		217389 EPHA2_HUMAN (4-789): 0: 587: 19.52		E41L2_HUMAN (11-519): 9.04e-113: 361: 19.70
+	Hs
		320536 EPHA2_HUMAN (4-789): 0: 587: 19.52		FARP2_HUMAN (3-537): 6.44e-112: 360: 17.89